Joseph J. Petraitis | Researchain

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Featured researches published by Joseph J. Petraitis.

Bioorganic & Medicinal Chemistry Letters | 1998

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Douglas G. Batt; Joseph J. Petraitis; Susan R. Sherk; Robert A. Copeland; Randine L. Dowling; Tracy L. Taylor; Elizabeth A. Jones; Ronald L. Magolda; Bruce D. Jaffee

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.

Bioorganic & Medicinal Chemistry Letters | 1998

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

William John Pitts; James W. Jetter; Donald J. P. Pinto; Michael J. Orwat; Douglas G. Batt; Susan R. Sherk; Joseph J. Petraitis; Irina C. Jacobson; Robert A. Copeland; Randine L. Dowling; Bruce D. Jaffee; Tracy L. Gardner; Elizabeth A. Jones; Ronald L. Magolda

The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution.

Archive | 1994

Prostaglandin synthase inhibitors

Douglas G. Batt; Donald J. P. Pinto; Michael J. Orwat; Joseph J. Petraitis; William John Pitts

Journal of Medicinal Chemistry | 2000

Disubstituted indazoles as potent antagonists of the integrin αvβ3

Douglas G. Batt; Joseph J. Petraitis; Gregory C. Houghton; Dilip P. Modi; Gary A. Cain; Martha H. Corjay; Shaker A. Mousa; Peter J. Bouchard; Mark S. Forsythe; Patricia P. Harlow; Frank A. Barbera; Susan M. Spitz; Ruth R. Wexler; Prabhakar K. Jadhav

Archive | 1995

Novel prostaglandin synthase inhibitors

Douglas G. Batt; Donald J. P. Pinto; Michael J. Orwat; Joseph J. Petraitis; William John Pitts

Archive | 1996

2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents

Douglas G. Batt; Joseph J. Petraitis; Susan R. Sherk

Bioorganic & Medicinal Chemistry Letters | 1999

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.

Donald J. P. Pinto; Douglas G. Batt; William John Pitts; Joseph J. Petraitis; Michael J. Orwat; Shuaige Wang; James W. Jetter; Susan R. Sherk; Gregory C. Houghton; Robert A. Copeland; Maryanne Covington; James M. Trzaskos; Ronald L. Magolda

Journal of Medicinal Chemistry | 2000

Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).

Douglas G. Batt; Joseph J. Petraitis; Gregory C. Houghton; Dilip P. Modi; Gary A. Cain; Martha H. Corjay; Shaker A. Mousa; Bouchard Pj; Mark S. Forsythe; Patricia P. Harlow; Frank A. Barbera; Susan M. Spitz; Ruth R. Wexler; Prabhakar K. Jadhav

Archive | 1993