Joseph Kent Barbay
Janssen Pharmaceutica
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Publication
Featured researches published by Joseph Kent Barbay.
Bioorganic & Medicinal Chemistry Letters | 2017
David A. Kummer; Maxwell D. Cummings; Marta Cristina Abad; Joseph Kent Barbay; Glenda Castro; Ronald L. Wolin; Kevin D. Kreutter; Umar Maharoof; Cynthia M. Milligan; Rachel Nishimura; Joan Pierce; Celine Schalk-Hihi; John Spurlino; Maud Urbanski; Hariharan Venkatesan; Aihua Wang; Craig R. Woods; Xiaohua Xue; James P. Edwards; Anne Fourie; Kristi A. Leonard
A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alcohol hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.
Archive | 2011
Paul F. Jackson; Brett A. Tounge; Kristi Leonard; Yan Zhang; Aihua Wang; Michael Hawkins; Umar Maharoof; Joseph Kent Barbay
Archive | 2009
Joseph Kent Barbay; Wei He; Yong Gong; Jian Li; Jean Van Wauwe; Mieke Buntinx
Archive | 2012
Kristi A. Leonard; Richard Alexander; Joseph Kent Barbay; Roger F. Bone; Carl S. Crysler; Ingrid Christa Deckman; Paul F. Jackson; Lawrence C. Kuo; Frank A. Lewandowski; Diane M. Maguire; Carl L. Manthey; Cynthia M. Milligan; Beverley A. Moore; Kenneth J. Rhodes; Robert H. Scannevin; Celine Schalk-Hihi; Barry Springer; John Spurlino; Matthew J. Todd; Brett A. Tounge; Aihua Wang
Archive | 2012
Kristi A. Leonard; Richard Alexander; Joseph Kent Barbay; Roger F. Bone; Ingrid Christa Deckman; Paul F. Jackson; Lawrence C. Kuo; Frank A. Lewandowski; Diane M. Maguire; Cynthia M. Milligan; Kenneth J. Rhodes; Robert H. Scannevin; Celine Schalk-Hihi; Barry Springer; John Spurlino; Matthew J. Todd; Brett A. Tounge; Aihua Wang
Archive | 2012
Paul F. Jackson; Carl L. Manthey; Kenneth J. Rhodes; Robert H. Scannevin; Kristi Leonard; Joseph Kent Barbay; Matthew J. Todd; Barry A. Springer
Archive | 2011
Kristi Leonard; Yan Zhang; Brett A. Tounge; Aihua Wang; Michael Hawkins; Paul F. Jackson; Joseph Kent Barbay; Umar Maharoof
Archive | 2011
Aihua Wang; Yan Zhang; Kristi Leonard; Michael Hawkins; Brett A. Tounge; Umar Maharoof; Joseph Kent Barbay
Archive | 2011
Joseph Kent Barbay; Kristi Leonard; Yan Zhang; Brett A. Tounge; Aihua Wang; Michael Hawkins; Paul F. Jackson; Umar Maharoof
Archive | 2018
Tianbao Lu; Brett Douglas Allison; Joseph Kent Barbay; Peter J. Connolly; Maxwell D. Cummings; Gaston Diels; James P. Edwards; Kevin D. Kreutter; Ulrike Philippar; Fang Shen; Johannes Wilhelmus John F. Thuring; Tongfei Wu
Collaboration
Dive into the Joseph Kent Barbay's collaboration.
