Joseph Masci

Marijuana Use Among the Adolescent Children of High-Risk Drug-Abusing Fathers

This study examines marijuana use among children of male drug abusers. Subjects were 83 African-American and European-American male drug abusers, of whom the majority were injection drug users, and their children. Thirty-one of the fathers were HIV-positive and 52 were HIV-negative. Using logistic regression analyses, we explored cross-sectionally the relationship between four psychosocial domains (ie, paternal attributes, adolescent problem behaviors, father-adolescent relations, and environment) and adolescent marijuana use. The fathers use of illegal drugs and his failure to cope adaptively predicted adolescent marijuana use, while a close father-child bond predicted less adolescent marijuana use. Adolescent problem behaviors predicted an increased likelihood of marijuana use. Furthermore, hierarchical regression analysis demonstrated that the adolescents problem behavior mediated the associations between both the father-adolescent relationship and environmental factors with adolescent marijuana use. Reducing the risk factors and enhancing the protective factors within each of the domains could help reduce marijuana use among the adolescent children of drug-abusing fathers. Moreover, if a father is a drug abuser, it is important to help him establish a close bond with his child in order to help attenuate the influence of his drug use on the childs marijuana use.

Needle sharing : a longitudinal study of female injection drug users

The objective of this study was to examine the psychosocial risk and protective factors related to needle-sharing behavior among female intravenous drug users (IDUs) positive (N = 96) and negative (N = 128) for human immunodeficiency virus (HIV). Participants in this longitudinal study were interviewed individually at two points in time, with a 6-month interval between interviews. The interviewers used a structured questionnaire, which included psychosocial measures and questions about drug and sexual risk behaviors. Data were analyzed using Pearson correlations and hierarchical regression analyses. The findings supported a developmental model in which the psychosocial domains and HIV status predicted T1 (initial) needle-sharing behavior, which in turn was related to T2 (follow-up) needle-sharing behavior. In addition, the relationship between personality and peer risk factors and T2 needle sharing was buffered by family-related protective factors. While HIV-positive status had a direct effect on T1 needle sharing with strangers, its effect was mediated by all of the psychosocial variables in its relation to T1 needle sharing with familiar people. Comparisons of these results were made with a companion study of male IDUs. The results suggest several intervention and treatment approaches that can be implemented at different points in the developmental pathways leading to risky needle-sharing practices among female IDUs.

Coping with Aids: A Longitudinal Study

The goals of this longitudinal, prospective study were to 1) examine coping strategies of HIV-positive (HIV+) and HIV-negative (HIV-) injecting drug users; 2) study the relationship of earlier social support to later coping in HIV+ men; and 3) examine the effects of earlier coping strategies on later psychosocial function. The authors studied 287 men given a structured questionnaire at two points in time. HIV+ subjects scored higher than HIV- subjects on measures of AIDS-related adaptive coping (social support) and AIDS-related maladaptive coping (aggression), but not on general coping. General coping was not specifically AIDS-related, but was correlated positively with adaptive coping and negatively with maladaptive coping. These results suggest that earlier general coping is related to the later avoidance of maladaptive coping, and they have specific implications for teaching preventive strategies. AIDS-related adaptive or maladaptive coping techniques may be used simultaneously, and coping behavior may change over time. Earlier social support is related positively to aspects of later coping in HIV+ men.

Coping with AIDS and the threat of AIDS in intravenous drug abusers

In this investigation of patterns of coping with AIDS or the threat of AIDS by male intravenous drug abusers (both HIV positive and HIV negative), psychosocial measures were used to study the effects of personality factors and social support. Correlational analyses and multiple hierarchical regression analyses were used to assess the results. The pathways by which psychosocial factors affected coping differed in HIV-positive and HIV-negative subjects. A mediational model best depicted the interrelation of personality, family, and peer factors among HIV-positive subjects. Anger and rebelliousness interfered with coping among HIV-negative subjects, but not among HIV-positive subjects. This cross-sectional study provides insight into the interplay of inner personality factors and external support factors and their effects on coping ability in male intravenous drug abusers. Differences between those with HIV and those at risk for HIV infection are discussed.

Amebiasis: Clinical and Laboratory Perspectives

Entamoeba histolytica, the premier intestinal protozoan, has traversed time in its relentless quest for survival in its dichotomous role of parasite and pathogen. Enigmatic in its transition from human intestinal commensal to invader of human tissue, diverse in its pathogenicity for the human host, and intricate in its bacterial interrelationship in the bowel, E. histolytica has become the focal point of intensive investigation in its basic biology underscoring human pathogenicity. This review will focus on facets of cell biology, pathophysiology, clinical, therapeutic, and epidemiologic, correlates, along with diagnostic modalities and future research trends.

EFFECTS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN EARLY INCIDENCE OF SYMPTOMATIC CORONARY ARTERY DISEASE

Data on the effect of CD4 count and HIV- viral load on cardiovascular disease is not consistent. Most studies suggest that lower CD4 count and higher HIV- viral load are associated with greater cardiovascular risk. In this study, we evaluated the early incidence of symptomatic CAD in HIV-infected