Joseph W. Yedlicka

Thrombolytic therapy for postoperative pulmonary embolism

The use of thrombolytic agents in the treatment of postoperative pulmonary embolism presents a dilemma to the surgeon. On one hand, postoperative pulmonary embolism usually occurs within 2 weeks of surgery. On the other hand, recent surgery is considered a contraindication for the use of thrombolytics. We developed a protocol for treating pulmonary embolism patients who have recently undergone surgery. Urokinase, at a dose of 2,200 U/kg wt, is injected directly into the clot via a catheter positioned in the pulmonary artery. This is followed by continuous infusions of urokinase at 2,200 U/kg wt/hr until the clot is lysed (up to 24 hrs). Simultaneously, heparin is administered peripherally at 500 U/hr. The level of serum fibrinogen is monitored every 6 hours and maintained at no less than 0.2 g/dL to prevent bleeding. Thirteen patients were treated for angiographically proven pulmonary embolism within 14 days of surgery. Complete lysis of every embolus was achieved, and no deaths or bleeding complications occurred. Two patients received inferior vena cava filters, and nine patients no longer needed chronic anticoagulants within 3 months after the embolic event.

LGM Vena Cava Filter: Objective Evaluation of Early Results

One hundred one LG-Medical (LGM) vena cava filters were placed in 97 patients at four institutions. Placement was a complete technical success in 90% (91 of 101). In 6% of attempts, LGM filter insertion was complicated by incomplete opening of the filter. Pulmonary embolism after filter placement was not definitely demonstrated in any patient. The probability of inferior vena cava patency was 92% at 6 months after filter insertion. Thrombosis at the insertion site was seen in eight of 35 patients (23%) evaluated with duplex ultrasound or venography. Thrombus was observed in 37% of filters at follow-up examination, with cephalic extension of thrombus above the filter in 20% of all patients examined. Filter migration (greater than 1 cm) was seen in 12%; significant angulation was observed in only one patient (2%). In vitro experimentation demonstrated that incomplete opening of the LGM filter during placement can be avoided, in part, by brisk retraction of the insertion cannula. The low-profile introducer system of the LGM filter allows increased alternatives in selecting the site for filter insertion. The low-profile system also makes outpatient filter placement a possibility. No significant difference in the prevalence of thrombosis at the insertion site following LGM filter insertion was noted compared with previous results reported for percutaneous transfemoral placement of the Greenfield filter. The nonopaque sheath does not permit careful localization prior to filter deposition. Modification of the LGM filter to include a radiopaque sheath is suggested.

Thrombolytic Therapy for Iliofemoral Venous Thrombosis

The authors outline a new approach to management of ileofemoral venous thrombosis: direct thrombolysis of the clot; identification of the cause of the thrombosis (usually iliac vein stenosis); then treatment of the obstructive process by balloon dilation, with or without the use of expanded stents; and reestablishment of venous flow.

The incidence of myocardial bridges in heart transplants

Coronary angiograms of 64 heart transplant patients were reviewed to determine the incidence of myocardial bridges. In 33% of the patients, myocardial bridges were detected, almost exclusively across the midportion of the left anterior descending coronary artery. The incidence is higher than previously reported in the literature and is thought to be related to increased stiffness and hypertrophy of the myocardium, which facilitates angiographic detection of myocardial bridges in the transplanted heart.

Chronic Iliac Artery Occlusions: Primary Recanalization with Endovascular Stents

PURPOSE The authors describe treatment of chronic iliac artery occlusions with primary stent placement without prior thrombolysis or angioplasty. PATIENTS AND METHODS Eight patients with chronic iliac artery occlusions (six men and two women) underwent primary stent placement without prior use of thrombolytic agents or angioplasty. Palmaz stents were placed in seven patients and a Wallstent device was placed in one. RESULTS In all patients, revascularization was successful without residual stenoses or pressure gradients. There was no angiographic evidence of distal embolization. CONCLUSION Primary stent placement for chronic iliac artery occlusions without prior thrombolysis or angioplasty appears to be safe and efficacious and is potentially cost effective.

Angiogenesis after Hepatic Arterial Occlusion in Liver Transplant Patients

The authors describe 10 liver transplant recipients who developed occlusion of the hepatic artery or aortic conduit. Since all potential collateral arterial supply to the transplant is severed at hepatectomy, hepatic artery occlusion is usually a catastrophic event that necessitates repeat transplantation. Four patients died within 8 weeks of transplantation. The remaining six developed spontaneous arterial liver revascularization. This phenomenon is believed to be an example of neovascularization through angiogenesis. Radiologic studies, particularly duplex sonography and angiography, were helpful in the evaluation of transplant vascular integrity. The tissues of the omentum and the mesentery have known angiogenic ability. The authors postulate that in transplantation techniques in which these tissues are placed close to the transplanted liver (eg, Roux-en-Y choledochojejunostomy), the omental and mesenteric tissues may be the source of neovascularity.

Spermatic Vein Occlusion with Hot Contrast Material: Angiographic Results

Spermatic vein occlusion by means of selective injection of boiling contrast material into the spermatic vein was attempted in 175 men with symptomatic varicoceles or infertility. Seventy-six patients (43%) returned for follow-up venography. Of 115 veins injected, 96 (83%) were totally occluded on the follow-up venogram obtained at 6 weeks to 2 years after injection. In the latter portion of the study, the technique was changed slightly, with injection of larger volumes of hot contrast material, resulting in a 91% occlusion rate. Each vein that was found patent on the follow-up venogram (19 of 115 [16%]) was assessed radiographically, and results were categorized as grade 1, a complete failure in which there was no change from the presclerotherapy appearance (nine of 19 [47%]); grade 2, a failure in which the treated vein was smaller but patent (five of 19 [26%]); or grade 3, a failure in which the treated vein was occluded with newly developed collateral vessels (five of 19 [26%]). The pretreatment size of the spermatic vein and the quantity of hot contrast material injected were both statistically significant factors in the treatment outcome.

Acute Clot-Trapping Efficiency in Dogs with Compacted versus Elongated Wires in Bird's Nest Filters

PURPOSE The clot-trapping efficiency of the Birds Nest filter was studied in dogs with the stainless steel wires in a compacted versus fully elongated configuration. MATERIALS AND METHODS Birds Nest filters were placed infrarenally with the wires compacted in 10 dogs and with the wires elongated in an additional 10 dogs. The dogs were separated into two groups, five dogs with each wire configuration in each group. In group 1, 10 unlabeled 6 x 30-mm blood clots were injected into the inferior vena cava. In group 2, six 6 x 10-mm, four 6 x 15-mm, and four 6 x 30-mm labeled clots were introduced. RESULTS In group 1, clot-trapping efficiencies were 82% for the compacted versus 86% for the elongated configuration, as seen on serial cavograms and pulmonary angiograms. In group 2, clot-trapping efficiencies were 90% for the compacted versus 97% for the elongated configuration, as seen at fluoroscopy. Clot size did not affect trapping efficiency. CONCLUSION Acute clot-trapping efficiency of Birds Nest filters did not differ when the wires were in a compacted versus elongated configuration. This study suggests that placement of a Birds Nest filter in the elongated configuration may be satisfactory and may not indicate placement of a second filter.

Portal vein reflectors : duplex sonographic appearance

Duplex sonography has established utility in the noninvasive evaluation of the portal venous system. Recently, the duplex sonographic features of suspected portal venous air have been described. We report on an experimental study in dogs undertaken to establish if the same sonographic features could be reproduced in a laboratory setting and to determine if small fragments of clot emboli could produce similar gray-scale and Doppler findings. Injections of microbubbles of air and clot fragments into the portal venous system were monitored using duplex ultrasound. The gray-scale and Doppler features of flow in the main portal vein were indistinguishable in both microbubble and clot injections. Superimposition of high-amplitude spikes on the normal portal venous waveform was seen in 19 of 24 (79%) microbubble and 13 of 23 (56%) clot fragment injections. We conclude that the appearance of rapidly moving, bright intraluminal echoes coupled with spike-like aberrations of the portal venous waveform can be associated with portal venous air bubbles or small blood clot emboli.

Nonselective and semiselective catheters for renal artery evaluation: experimental study.

Abdominal aortography is widely used for evaluation of potential renal donors and for patients with renal failure or hypertension in whom a renal artery ostial or polar branch stenosis is suspected. It would be desirable to use a catheter that consistently enables good bilateral renal artery and polar branch visualization without opacification of overlying mesenteric vessels. Existing and newly designed catheters were compared to determine the optimal design necessary for these studies. An in vitro model of the abdominal aorta and its branches was made, and dye dilution densitometry was employed for quantitative evaluation. Semiselective catheters demonstrated significantly increased renal artery opacification with decreased mesenteric opacification in this in vitro model.