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Dive into the research topics where Joshua I. Breier is active.

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Featured researches published by Joshua I. Breier.


Neurology | 2002

Dyslexia-specific brain activation profile becomes normal following successful remedial training

Panagiotis G. Simos; Jack M. Fletcher; E. Bergman; Joshua I. Breier; Barbara R. Foorman; E. M. Castillo; Robert N. Davis; Michele E. Fitzgerald; Andrew C. Papanicolaou

Objectives To examine changes in the spatiotemporal brain activation profiles associated with successful completion of an intensive intervention program in individual dyslexic children. Methods The authors obtained magnetic source imaging scans during a pseudoword reading task from eight children (7 to 17 years old) before and after 80 hours of intensive remedial instruction. All children were initially diagnosed with dyslexia, marked by severe difficulties in word recognition and phonologic processing. Eight children who never experienced reading problems were also tested on two occasions separated by a 2-month interval. Results Before intervention, all children with dyslexia showed distinctly aberrant activation profiles featuring little or no activation of the posterior portion of the superior temporal gyrus (STGp), an area normally involved in phonologic processing, and increased activation of the corresponding right hemisphere area. After intervention that produced significant improvement in reading skills, activity in the left STGp increased by several orders of magnitude in every participant. No systematic changes were obtained in the activation profiles of the children without dyslexia as a function of time. Conclusions These findings suggest that the deficit in functional brain organization underlying dyslexia can be reversed after sufficiently intense intervention lasting as little as 2 months, and are consistent with current proposals that reading difficulties in many children represent a variation of normal development that can be altered by intensive intervention.


Epilepsia | 1999

A Comparison of Magnetoencephalography, MRI, and V-EEG in Patients Evaluated for Epilepsy Surgery

James W. Wheless; L. J. Willmore; Joshua I. Breier; M. Kataki; Joseph R. Smith; Don W. King; Kimford J. Meador; Y. D. Park; David W. Loring; Guy L. Clifton; James E. Baumgartner; A. Thomas; J. E. C. Constantinou; Andrew C. Papanicolaou

Summary: Purpose: To determine the efficacy and relative contribution of several diagnostic methods [ictal and interictal scalp and intracranial EEG, magnetic resonance imaging (MRI), and magnetoencephalography (MEG)] in identifying the epileptogenic zone for resection.


Neurology | 1999

Language dominance determined by magnetic source imaging A comparison with the Wada procedure

Joshua I. Breier; Panagiotis G. Simos; George Zouridakis; James W. Wheless; L. J. Willmore; Jules E. C. Constantinou; William W. Maggio; Andrew C. Papanicolaou

Objective: To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder.Method:— The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy patients who also underwent the intracarotid amobarbital (Wada) procedure. During MSI recordings, patients engaged in a word recognition task. This task was shown previously to activate language areas in normal adults as well as in patients who undergo intraoperative language mapping, allowing confirmation of MSI findings. Language laterality indices were formed for both the Wada and the MSI procedures. In addition, clinical judgments regarding cerebral dominance for language were made using the two methods by independent raters. Results: Cluster analysis indicated excellent agreement between the quantitative MSI and Wada indices. Rater judgments showed almost complete agreement as well. Conclusion: MSI is a promising method for determining cerebral dominance for language.


Neuroscience Letters | 2000

Brain activation profiles in dyslexic children during non-word reading: a magnetic source imaging study.

Panagiotis G. Simos; Joshua I. Breier; Jack M. Fletcher; Barbara R. Foorman; Eldo Bergman; Kristen Fishbeck; Andrew C. Papanicolaou

The purpose of the study was to identify spatiotemporal brain activation profiles associated with phonological decoding in dyslexic children using magnetic source imaging. For this purpose maps of regional cerebral activation were obtained from eleven children diagnosed with dyslexia and ten children without reading problems during engagement in a pseudoword rhyme-matching task. All dyslexic children showed aberrant activation maps consisting of reduced activity in temporoparietal areas in the left hemisphere (including the posterior part of the superior temporal, angular and supramarginal gyri) and increased activity in the right homotopic region. In contrast, the two groups of children did not differ in the degree of activity in basal temporal areas that typically precedes temporoparietal activation. This is the first study to demonstrate the existence of distinct activation profiles associated with phonological decoding in individual dyslexic children.


Neurology | 2004

Does magnetoencephalography add to scalp video-EEG as a diagnostic tool in epilepsy surgery?

Ekaterina Pataraia; Panagiotis G. Simos; E. M. Castillo; Rebecca L. Billingsley; Shirin Sarkari; James W. Wheless; Vijay Maggio; William W. Maggio; James E. Baumgartner; Paul R. Swank; Joshua I. Breier; Andrew C. Papanicolaou

Objective: The authors evaluated the sensitivity and selectivity of interictal magnetoencephalography (MEG) versus prolonged ictal and interictal scalp video-electroencephalography (V-EEG) in order to identify patient groups that would benefit from preoperative MEG testing. Methods: The authors evaluated 113 consecutive patients with medically refractory epilepsy who underwent surgery. The epileptogenic region predicted by interictal and ictal V-EEG and MEG was defined in relation to the resected area as perfectly overlapping with the resected area, partially overlapping, or nonoverlapping. Results: The sensitivity of a 30-minute interictal MEG study for detecting clinically significant epileptiform activity was 79.2%. Using MEG, we were able to localize the resected region in a greater proportion of patients (72.3%) than with noninvasive V-EEG (40%). MEG contributed to the localization of the resected region in 58.8% of the patients with a nonlocalizing V-EEG study and 72.8% of the patients for whom V-EEG only partially identified the resected zone. Overall, MEG and V-EEG results were equivalent in 32.3% of the cases, and additional localization information was obtained using MEG in 40% of the patients. Conclusion: MEG is most useful for presurgical planning in patients who have either partially or nonlocalizing V-EEG results.


Neuroreport | 2000

Brain mechanisms for reading : the role of the superior temporal gyrus in word and pseudoword naming

Panagiotis G. Simos; Joshua I. Breier; James W. Wheless; William W. Maggio; Jack M. Fletcher; Eduardo M. Castillo; Andrew C. Papanicolaou

The purpose of this study was to test the neurological validity of a dual-route model of reading by asking patients, who were undergoing electrocortical stimulation mapping, to read words with irregular print-to-sound correspondences and pseudowords. Brain activation profiles were also obtained from these patients during an auditory and a visual word recognition task using whole-head magnetic source imaging. We demonstrated that reading is subserved by at least two brain mechanisms that are anatomically dissociable. One mechanism subserves assembled phonology and depends on the activity of the posterior part of the left superior temporal gyrus (STGp), whereas the second is responsible for addressed phonology and does not necessarily involve this region. The contribution of STGp to reading appears to be based on its specialization for phonological analysis operations, involved in the processing of both spoken and written language.


American Journal of Neuroradiology | 2008

Language Dysfunction After Stroke and Damage to White Matter Tracts Evaluated Using Diffusion Tensor Imaging

Joshua I. Breier; Khader M. Hasan; Wenbo Zhang; Disheng Men; Andrew C. Papanicolaou

BACKGROUND AND PURPOSE: Knowledge of the anatomic basis of aphasia after stroke has both theoretic and clinical implications by informing models of cortical connectivity and providing data for diagnosis and prognosis. In this study we use diffusion tensor imaging to address the relationship between damage to specific white matter tracts and linguistic deficits after left hemisphere stroke. MATERIALS AND METHODS: Twenty patients aged 38–77 years with a history of stroke in the left hemisphere underwent diffusion tensor imaging, structural MR imaging, and language testing. All of the patients were premorbidly right handed and underwent imaging and language testing at least 1 month after stroke. RESULTS: Lower fractional anisotropy (FA) values in the superior longitudinal and arcuate fasciculi of the left hemisphere, an indication of greater damage to these tracts, were correlated with decreased ability to repeat spoken language. Comprehension deficits after stroke were associated with lower FA values in the arcuate fasciculus of the left hemisphere. The findings for repetition were independent of MR imaging ratings of the degree of damage to cortical areas of the left hemisphere involved in language function. There were no findings for homotopic tracts in the right hemisphere. CONCLUSION: This study provides support for a specific role for damage to the superior longitudinal and arcuate fasciculi in the left hemisphere in patients with deficits in repetition of speech in aphasia after stroke.


Developmental Neuropsychology | 2003

Interventions Aimed at Improving Reading Success: An Evidence-Based Approach

Barbara R. Foorman; Joshua I. Breier; Jack M. Fletcher

There is a consensus among researchers about the critical elements for effective reading instruction. These elements are the integration of explicit instruction in the alphabetic principle, reading for meaning, and opportunity to learn. These critical elements are present in classroom instruction that prevents reading difficulties as well as effective small-group and one-on-one interventions. Research on effective classroom instruction and reading interventions is described, and the case is argued that the most effective intervention is provided early-in kindergarten through 2nd grade-rather than after 3rd grade, and allows for sufficient intensity, duration, and supportiveness that no child is left behind. Policy implications for changes in (a) the way learning disabilities are identified and (b) the content of professional development of teachers are discussed.


Journal of Child Neurology | 2001

Language Dominance in Children as Determined by Magnetic Source Imaging and the Intracarotid Amobarbital Procedure: A Comparison

Joshua I. Breier; Panagiotis G. Simos; James W. Wheless; Jules E. C. Constantinou; James E. Baumgartner; Vijayalakshmi Venkataraman; Andrew C. Papanicolaou

This study evaluated the validity of data derived from magnetic source imaging regarding hemispheric dominance for language in children and adolescents with intractable seizure disorder by comparison with results of the intracarotid amobarbital procedure. Functional imaging of the receptive language cortex using a whole-head neuromagnetometer was performed in 19 consecutive epilepsy patients, ages 8 to 18 years, who also underwent the intracarotid amobarbital procedure. During magnetic source imaging recordings, patients engaged in a continuous recognition memory task for words in visual and auditory modalities. This task has previously been shown to be valid for the purpose of lateralization and localization of language cortex in adult epilepsy patients who undergo the intracarotid amobarbital procedure and intraoperative language mapping allowing confirmation of magnetic source imaging findings. Results indicated that language laterality indices formed for the intracarotid amobarbital procedure and magnetic source imaging procedures were highly correlated (R = .87). In addition, clinical judgments regarding cerebral dominance for language made by independent raters using the two methods were in excellent agreement. We conclude that magnetic source imaging is a promising method for determination of cerebral dominance for language in children and adults. (J Child Neurol 2001;16:124-130).


Neurology | 2004

Reorganization of language-specific cortex in patients with lesions or mesial temporal epilepsy

Ekaterina Pataraia; Panagiotis G. Simos; E. M. Castillo; Rebecca Billingsley-Marshall; A. L. McGregor; Joshua I. Breier; Shirin Sarkari; Andrew C. Papanicolaou

Objective: To examine brain activation profiles for receptive language function, using magnetoencephalography (MEG), in patients with left hemisphere space-occupying lesions and patients with left temporal lobe epilepsy due to mesial temporal sclerosis (MTS) and to evaluate whether cross- and intrahemispheric plasticity for language varied as a function of lesion type or location. Methods: Twenty-one patients with MTS and 23 lesional patients underwent preoperative language mapping while performing a word recognition task. The anatomic location of late activity sources was determined by co-registering MEG coordinates onto structural MRI scans. A language laterality index was calculated based on the number of activity sources in each hemisphere. The location of language-specific activity was examined in relation to its proximity or overlap with Wernicke’s area. Results: A higher incidence of atypical language lateralization was noted among patients with MTS than lesional patients (43 vs 13%). The majority of MTS patients with early seizure onset (before age 5) showed atypical language lateralization. In contrast, the precise location of receptive language-specific cortex within the dominant hemisphere was found to be atypical (outside of Wernicke’s area) in 30% of lesional patients and only 14% of MTS patients. Conclusions: There is an increased probability of a partial or total displacement of key components of the brain mechanism responsible for receptive language function to the nondominant hemisphere in mesial temporal sclerosis patients. Early onset of seizures is strongly associated with atypical language lateralization. Lesions in the dominant hemisphere tend to result in an intrahemispheric reorganization of linguistic function.

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James W. Wheless

University of Tennessee Health Science Center

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Eduardo M. Castillo

University of Texas Health Science Center at Houston

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George Zouridakis

University of Texas Health Science Center at Houston

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William W. Maggio

University of Texas Health Science Center at Houston

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Jules E. C. Constantinou

University of Texas Health Science Center at Houston

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Lincoln Gray

James Madison University

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