Josiah J. Bonire
Ahmadu Bello University
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Featured researches published by Josiah J. Bonire.
Journal of Inorganic Biochemistry | 2001
Josiah J. Bonire; Simon P. Fricker
Platinum compounds containing the ligand 1,2-diaminocyclohexane (DACH) such as tetraplatin [PtCl4(DACH)] have been found to be active in cisplatin-resistant tumour models. In an attempt to develop novel metal-based drugs with a different therapeutic profile to cisplatin, we have synthesised a series of tin compounds containing the DACH ligand, including the Sn analogue of tetraplatin [SnCl4(DACH)], and the di- and monoorganotin complexes [Ph2Sn(OAc)2(DACH)], [Bu2Sn(OAc)2(DACH)], [PhSnCl3(DACH)], [BuSn(OAc)3(DACH)], [BuSnCl3(DACH)], and [PhSn(OCOCF3)3(DACH)]. Mossbauer and IR spectroscopy indicates that the Sn(DACH) complexes are hexacoordinated with a molecular structure similar to that of tetraplatin. These compounds were tested for potential antitumour activity against a panel of human tumour cell lines, (SW620, SW1116 colon carcinoma, ZR-75-1 breast carcinoma, HT1376 bladder carcinoma, SKOV-3, PA-1 ovarian carcinoma). [Ph2Sn(penicillinate)], [Ph2Sn(OCOCH2NCOCH2NH2)], [Ph2Sn(OAc)2] were included for comparison. The results show that whereas [SnCl4(DACH)] and the monoorganotin complexes had limited or no activity, the diorganotin DACH complexes were cytotoxic with an associated increase in potency on going from diphenyl to dibutyltin, with mean IC50 values of 7.26+/-4.09 micromol ml(-1) for [Ph2Sn(OAc)2(DACH)] and 2.58+/-0.83 micromol ml(-1) for [Bu2Sn(OAc)2(DACH)] across the cell line panel. Comparison with [Ph2Sn(OAc)2] (IC50 0.69-0.43 micromol ml(-1)) indicated that addition of the DACH ligand resulted in a decrease in cytotoxicity but increased differential toxicity across the cell line panel. These results indicate that the diorganotin DACH complexes merit further investigation as potential metal-based antitumour drugs.
Metal-based Drugs | 1998
Josiah J. Bonire; G. Adefikayo Ayoko; Philip F. Olurinola; Joseph O. Ehinmidu; N. S. Neelam Jalil; Andrew A. Omachi
Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids from which they were synthesized. In keeping with the generally accepted notion that the organotin moiety plays an important role in deciding the antifungal activity of an organotin compound, the diphenyltin(IV) compounds were more active than their di-n-butyltin(IV) analogues. However, the order of increasing fungitoxicity of the compounds parallels that of the uncomplexed carboxylic acids. The implications of the results are discussed.
Synthesis and Reactivity in Inorganic and Metal-organic Chemistry | 1998
N. S. Neelam Jalil; Josiah J. Bonire; I. Y. Abdulmumin
Abstract The vanadium(V)-thrombin complex was prepared in solution by the interaction of H2VO4 − with human thrombin. The interaction between vanadate and the protein was characterized by UV spectroscopy and titrations. The binding constant was calculated to be 104−−9 M-2. A model complex of vanadium with trypsin was also prepared and studied by UV difference spectra to compare the binding sites of trypsin with thrombin for vanadate. It is concluded that vanadium is binding as vanadate to carboxyamide groups of the glutamine residues.
Applied Organometallic Chemistry | 2003
Godwin A. Ayoko; Josiah J. Bonire; Shettima S. Abdulkadir; Philip F. Olurinola; Joseph O. Ehinmidu; Serge Kokot; Stephen Yiasel
Journal of the Science of Food and Agriculture | 1990
Josiah J. Bonire; N. S. Neelam Jalil; Joseph A Lori
Applied Organometallic Chemistry | 2003
Andrew J. Nok; Ishaya H. Nock; Josiah J. Bonire
Journal of the Science of Food and Agriculture | 1991
Josiah J. Bonire; Neelam N S Jalil; Joseph A Lori
Applied Organometallic Chemistry | 1994
Josiah J. Bonire; Alan J. Crowe; Peter J. Smith
Nigerian Journal of Chemical Research | 2006
As Shettima; Josiah J. Bonire; Nsn Jalil; Ga Ayoko; Sg Yiase
Nigerian Journal of Chemical Research | 2006
Josiah J. Bonire; Philip F. Olurinola; Joseph O. Ehinmidu; As Shettima; Sg Yiase