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Dive into the research topics where Josiah J. Bonire is active.

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Featured researches published by Josiah J. Bonire.


Journal of Inorganic Biochemistry | 2001

The in vitro antitumour profile of some 1,2-diaminocyclohexane organotin complexes

Josiah J. Bonire; Simon P. Fricker

Platinum compounds containing the ligand 1,2-diaminocyclohexane (DACH) such as tetraplatin [PtCl4(DACH)] have been found to be active in cisplatin-resistant tumour models. In an attempt to develop novel metal-based drugs with a different therapeutic profile to cisplatin, we have synthesised a series of tin compounds containing the DACH ligand, including the Sn analogue of tetraplatin [SnCl4(DACH)], and the di- and monoorganotin complexes [Ph2Sn(OAc)2(DACH)], [Bu2Sn(OAc)2(DACH)], [PhSnCl3(DACH)], [BuSn(OAc)3(DACH)], [BuSnCl3(DACH)], and [PhSn(OCOCF3)3(DACH)]. Mossbauer and IR spectroscopy indicates that the Sn(DACH) complexes are hexacoordinated with a molecular structure similar to that of tetraplatin. These compounds were tested for potential antitumour activity against a panel of human tumour cell lines, (SW620, SW1116 colon carcinoma, ZR-75-1 breast carcinoma, HT1376 bladder carcinoma, SKOV-3, PA-1 ovarian carcinoma). [Ph2Sn(penicillinate)], [Ph2Sn(OCOCH2NCOCH2NH2)], [Ph2Sn(OAc)2] were included for comparison. The results show that whereas [SnCl4(DACH)] and the monoorganotin complexes had limited or no activity, the diorganotin DACH complexes were cytotoxic with an associated increase in potency on going from diphenyl to dibutyltin, with mean IC50 values of 7.26+/-4.09 micromol ml(-1) for [Ph2Sn(OAc)2(DACH)] and 2.58+/-0.83 micromol ml(-1) for [Bu2Sn(OAc)2(DACH)] across the cell line panel. Comparison with [Ph2Sn(OAc)2] (IC50 0.69-0.43 micromol ml(-1)) indicated that addition of the DACH ligand resulted in a decrease in cytotoxicity but increased differential toxicity across the cell line panel. These results indicate that the diorganotin DACH complexes merit further investigation as potential metal-based antitumour drugs.


Metal-based Drugs | 1998

Synthesis and Antifungal Activity of Some Organotin(IV) Carboxylates

Josiah J. Bonire; G. Adefikayo Ayoko; Philip F. Olurinola; Joseph O. Ehinmidu; N. S. Neelam Jalil; Andrew A. Omachi

Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids from which they were synthesized. In keeping with the generally accepted notion that the organotin moiety plays an important role in deciding the antifungal activity of an organotin compound, the diphenyltin(IV) compounds were more active than their di-n-butyltin(IV) analogues. However, the order of increasing fungitoxicity of the compounds parallels that of the uncomplexed carboxylic acids. The implications of the results are discussed.


Synthesis and Reactivity in Inorganic and Metal-organic Chemistry | 1998

Complexing Behaviour of Vanadate Towards Thrombin

N. S. Neelam Jalil; Josiah J. Bonire; I. Y. Abdulmumin

Abstract The vanadium(V)-thrombin complex was prepared in solution by the interaction of H2VO4 − with human thrombin. The interaction between vanadate and the protein was characterized by UV spectroscopy and titrations. The binding constant was calculated to be 104−−9 M-2. A model complex of vanadium with trypsin was also prepared and studied by UV difference spectra to compare the binding sites of trypsin with thrombin for vanadate. It is concluded that vanadium is binding as vanadate to carboxyamide groups of the glutamine residues.


Applied Organometallic Chemistry | 2003

A Multicriteria Ranking of Organotin (IV) Compounds with Fungicidal Properties

Godwin A. Ayoko; Josiah J. Bonire; Shettima S. Abdulkadir; Philip F. Olurinola; Joseph O. Ehinmidu; Serge Kokot; Stephen Yiasel


Journal of the Science of Food and Agriculture | 1990

Sodium and potassium content of two cultivars of white yam (Dioscorea rotundata) and their source soils.

Josiah J. Bonire; N. S. Neelam Jalil; Joseph A Lori


Applied Organometallic Chemistry | 2003

The cholesterol pathway of Trypanosoma congolense could be a target for triphenyltinsalicylate and triphenylsiliconsalicylate inhibition

Andrew J. Nok; Ishaya H. Nock; Josiah J. Bonire


Journal of the Science of Food and Agriculture | 1991

Iron, nickel, copper, zinc and cadmium content of two cultivars of white yam (Dioscorea rotundata) and their source soils

Josiah J. Bonire; Neelam N S Jalil; Joseph A Lori


Applied Organometallic Chemistry | 1994

o‐Cyclohexadiamine complexes of some diorganotin, mono‐organtotin and stannic carboxylates: Synthesis and spectral properties

Josiah J. Bonire; Alan J. Crowe; Peter J. Smith


Nigerian Journal of Chemical Research | 2006

Reactions of 4-picoline with trimethyltin carboxylates

As Shettima; Josiah J. Bonire; Nsn Jalil; Ga Ayoko; Sg Yiase


Nigerian Journal of Chemical Research | 2006

Synthesis and some spectral properties of diphenylsilicon salicylate and a comparision of the antifungal efficacy of diphenylsilicon chloride, acetate and salicylate and diphenyltin chloride, acetate and salicylate on Candida albicans

Josiah J. Bonire; Philip F. Olurinola; Joseph O. Ehinmidu; As Shettima; Sg Yiase

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As Shettima

Ahmadu Bello University

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Sg Yiase

Ahmadu Bello University

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Nsn Jalil

Ahmadu Bello University

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Ga Ayoko

Queensland University of Technology

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Godwin A. Ayoko

Queensland University of Technology

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