Josiane de Souza

Does serum ferritin correlate with coronary angiography findings

BACKGROUND A number of epidemiological studies have described a positive relationship between serum ferritin levels and coronary heart disease. In this prospective study, we evaluated the association between serum ferritin levels and the angiographic extent of coronary atherosclerosis. METHOD We studied 307 consecutive patients (60.9% male, age 60.1+/-11.0 years) referred for diagnostic coronary angiography. Risk factors for coronary artery disease, lipids and ferritin levels, as well clinical characteristics were recorded from all patients. Two experienced cardiologists blinded for clinical and laboratory data reviewed the cinefilms. Angiographic significant coronary artery disease (CAD) was defined as any more than a 50% diameter stenosis. RESULTS From the 307 patients, 196 (63.8%) were found to have angiographic significant CAD. The presence of significant CAD was associated with ferritin levels (P=0.015) as well as patient age (P<0.001), male sex (P<0.001), smoking (P<0.002), and cholesterol levels (P=0.028). By multivariate analysis, however, ferritin level was not an independent risk factor for CAD (P=0.27), while the association with all the other factors remained significant. CONCLUSION In patients referred for coronary angiography no independent relationship was found between angiographic significant coronary artery disease and serum ferritin levels.

Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography

Many clinical and epidemiological studies have demonstrated the relationship between serum ferritin and ischemic heart disease. In the present study we evaluated the relationship between coronary heart disease (CHD) and serum ferritin levels in patients submitted to coronary arteriography. We evaluated 307 patients (210 (68.7%) males; median age: 60 years) who were submitted to coronary angiography, measurement of serum ferritin and identification of clinical events of ischemic heart disease. Serum ferritin is reported as quartiles. Ninety-six patients (31.27%) had normal coronary angiography (group 1) and 211 (68.73%) had coronary heart disease (group 2). Of the patients with CHD, 61 (28.9%) had serum ferritin levels higher than 194 ng/ml (4th quartile), as opposed to only 14 (14.58%) of those without CHD (P = 0.0067). In the 2nd quartile, 39 patients (18.48%) had CHD, while 35 patients (36.46%) had normal coronary arteries (P = 0.00064). Multivariate analysis of the data showed that the difference between groups was not statistically significant (P = 0.33). We conclude that there is no independent relationship between coronary heart disease and increased levels of serum ferritin.

Comparação da aterosclerose coronária em pacientes com infarto do miocárdio e angina do peito

Objetivo - Comparar a gravidade da doenca coronaria e a presenca de fatores de risco cardiovasculares entre pacientes com angina e infarto do miocardio (IM). Metodos - Estudaram-se 62 pacientes com IM e 129 com angina, atraves de cineangiocoronariografia, avaliando-se a oclusao (lesao de 99% ou 100%), a severidade (escore de 0 a 5 de acordo com o numero de vasos afetados) e a extensao (3 grupos com diferentes graus de estenose). Dois observadores experientes interpretaram cegamente os angiogramas. Resultados - Os pacientes com IM tiveram maior oclusao (50% vs 13,2% [p<0,01]), maior severidade (79% vs 54,3% com mais de 90% de estenose [p<0,02]) e maior extensao (2,0 vs 0,87 [p<0,001]), mesmo quando controlados para os fatores de risco coronarios classicos e para o tempo de doenca. O tabagismo foi o unico fator de risco independente correlacionado com IM (P<0,01). Conclusao - Entre os pacientes estudados, a doenca coronaria foi maior no grupo IM, bem como a prevalencia de tabagismo.Objetivo - Comparar a gravidade da doenca coronaria e a presenca de fatores de risco cardiovasculares entre pacientes com angina e infarto do miocardio (IM). Metodos - Estudaram-se 62 pacientes com IM e 129 com angina, atraves de cineangiocoronariografia, avaliando-se a oclusao (lesao de 99% ou 100%), a severidade (escore de 0 a 5 de acordo com o numero de vasos afetados) e a extensao (3 grupos com diferentes graus de estenose). Dois observadores experientes interpretaram cegamente os angiogramas. Resultados - Os pacientes com IM tiveram maior oclusao (50% vs 13,2% [p<0,01]), maior severidade (79% vs 54,3% com mais de 90% de estenose [p<0,02]) e maior extensao (2,0 vs 0,87 [p<0,001]), mesmo quando controlados para os fatores de risco coronarios classicos e para o tempo de doenca. O tabagismo foi o unico fator de risco independente correlacionado com IM (P<0,01). Conclusao - Entre os pacientes estudados, a doenca coronaria foi maior no grupo IM, bem como a prevalencia de tabagismo.

DISCURSIVE APPROPRIATION OF TEACHING TRAINING MODELS IN CONCLUSION WORKS OF A PHYSICS TEACHING MASTER

Este trabajo tiene el objetivo de investigar, en tres trabajos de conclusion, la apropiacion discursiva del modelo de formacion docente con el cual la Maestria Profesional en Ensenanza de la Fisica de la UFRGS se compromete. Inicialmente, deprendemos, por medio de un analisis bakhtiniano de la propuesta inicial del curso y de su curriculum, considerado como contexto extra-verbal del objeto de analisis, que el modelo de formacion es el del especialista tecnico. Enseguida, el analisis bakhtiniano de los trabajos permitio inferir la forma como los profesores-alumnos se apropian de ese discurso, cuando, por ejemplo, presentan referenciales teoricos desvinculados al producto educacional propuesto, no consideran la realidad educacional de la escuela o se basan solamente en el discurso oficial o por testes internacionales de aprendizaje.This paper investigates, in three dissertations, the discursive appropriation of the teacher training model that the Professional Master in Physics Teaching at UFRGS promotes.First of all we performed a Bakhtinian analysis of the course’s initial proposal and its curriculum, considered as extra verbal-context, from which we were able to infer that this training model is technical specialist. In the following, also by means of the Bakhtinian analysis, we were able to infer the way that teachers-students appropriate of this model, when, for example, the theoretical framework isn’t articulated to the educational product developed, disregarded from real school’s educational needs, or it is based on official educational discourse and international learning tests.

APROPIACIÓN DISCURSIVA DE MODELOS DE FORMACIÓN DOCENTE EN TRABAJOS DE CONCLUSIÓN DE UNA MAESTRÍA PROFESIONAL EN ENSEÑANZA DE LA FÍSICA

Este trabajo tiene el objetivo de investigar, en tres trabajos de conclusion, la apropiacion discursiva del modelo de formacion docente con el cual la Maestria Profesional en Ensenanza de la Fisica de la UFRGS se compromete. Inicialmente, deprendemos, por medio de un analisis bakhtiniano de la propuesta inicial del curso y de su curriculum, considerado como contexto extra-verbal del objeto de analisis, que el modelo de formacion es el del especialista tecnico. Enseguida, el analisis bakhtiniano de los trabajos permitio inferir la forma como los profesores-alumnos se apropian de ese discurso, cuando, por ejemplo, presentan referenciales teoricos desvinculados al producto educacional propuesto, no consideran la realidad educacional de la escuela o se basan solamente en el discurso oficial o por testes internacionales de aprendizaje.This paper investigates, in three dissertations, the discursive appropriation of the teacher training model that the Professional Master in Physics Teaching at UFRGS promotes.First of all we performed a Bakhtinian analysis of the course’s initial proposal and its curriculum, considered as extra verbal-context, from which we were able to infer that this training model is technical specialist. In the following, also by means of the Bakhtinian analysis, we were able to infer the way that teachers-students appropriate of this model, when, for example, the theoretical framework isn’t articulated to the educational product developed, disregarded from real school’s educational needs, or it is based on official educational discourse and international learning tests.

APROPRIAÇÃO DISCURSIVA DE MODELOS DE FORMAÇÃO DOCENTE EM TRABALHOS DE CONCLUSÃO DE UM MESTRADO PROFISSIONAL EM ENSINO DE FÍSICA

Este trabajo tiene el objetivo de investigar, en tres trabajos de conclusion, la apropiacion discursiva del modelo de formacion docente con el cual la Maestria Profesional en Ensenanza de la Fisica de la UFRGS se compromete. Inicialmente, deprendemos, por medio de un analisis bakhtiniano de la propuesta inicial del curso y de su curriculum, considerado como contexto extra-verbal del objeto de analisis, que el modelo de formacion es el del especialista tecnico. Enseguida, el analisis bakhtiniano de los trabajos permitio inferir la forma como los profesores-alumnos se apropian de ese discurso, cuando, por ejemplo, presentan referenciales teoricos desvinculados al producto educacional propuesto, no consideran la realidad educacional de la escuela o se basan solamente en el discurso oficial o por testes internacionales de aprendizaje.This paper investigates, in three dissertations, the discursive appropriation of the teacher training model that the Professional Master in Physics Teaching at UFRGS promotes.First of all we performed a Bakhtinian analysis of the course’s initial proposal and its curriculum, considered as extra verbal-context, from which we were able to infer that this training model is technical specialist. In the following, also by means of the Bakhtinian analysis, we were able to infer the way that teachers-students appropriate of this model, when, for example, the theoretical framework isn’t articulated to the educational product developed, disregarded from real school’s educational needs, or it is based on official educational discourse and international learning tests.

Comparative study for the identification of myocardial ischemia by contrast ventriculography under the effect of isosorbide mononitrate and by perfusional myocardial scintigraphy in patients with ischemic heart disease

OBJECTIVE To evaluate and compare the usefulness of cineventriculographies, before and after nitrate use, to technetium-99m sestamibi scintigraphy for the identification of myocardial ischemia. METHODS Twenty-six patients were studied at basal conditions and 5 minutes after intravenous administration of isosorbide mononitrate (0.3 mg/kg), to evaluate the performance and regional wall motion of the left ventricle (LV). The results were compared too those obtained with technetium-99m sestamibi scintigraphy. RESULTS Before nitrate, contrast ventriculography identified 30 normal segments, 62 hypokinetic segments, 28 dyskinetic segments, and 14 akinetic segments. After drug administration, 99 segments were normal, 11 hypokinetic, 11 dyskinetic, and 13 akinetic. Myocardial scintigraphy revealed 110 ischemic segments and 18 fibrotic segments (p < 0.005). After drug administration, the ventriculography showed increase in the velocity of circumferential fiber shortening (p = 0.0142), the ejection fraction (p = 0.0462), decrease in the end-systolic volume (p = 0.0031) and no change in end-diastolic volume. CONCLUSION Contrast ventriculography using nitrate proved to be similar to perfusional myocardial scintigraphy in the identification of myocardial ischemia.