Josien C. van den Noort

Evaluation of clinical spasticity assessment in Cerebral palsy using inertial sensors

Spasticity is clinically assessed using goniometry to measure the joint angle of the catch (AOC) during fast passive muscle stretch. The precision and accuracy of the goniometric AOC measurements are questionable, because of the inevitable joint repositioning after occurrence of the catch. This study aims to evaluate the use of goniometry in estimating the AOC in spasticity assessment of the medial hamstrings, soleus and gastrocnemius in twenty children with Cerebral palsy (CP), using inertial sensors (IS) as reference system. The IS were initially validated with an optoelectronic system to measure 3d-orientation and proved to be accurate within 1 degree. To evaluate the precision and accuracy of the goniometry, the joint angle measured with the goniometer after repositioning was compared to the joint angle measured simultaneously with the IS, and to the true AOC, detected and measured with the IS during the fast muscle stretch. Results showed that goniometry is an imprecise method to measure the true AOC in spasticity assessment. The error is mainly due to joint repositioning after the fast muscle stretch. For spasticity assessment, it is advised to apply inertial sensors when a precise measurement of the angle of catch is required.

The effectiveness of voluntary modifications of gait pattern to reduce the knee adduction moment

It has been suggested to use gait modifications in the retraining of patients with knee osteoarthritis (OA), in order to reduce the external knee adduction moment (KAdM). This study focused on the effect of walking speed, foot position and trunk sway, and on the 3D knee moments. Gait analyses of fourteen healthy volunteers were performed in a gait laboratory. Subjects walked at three different speeds in their normal gait pattern, as well as with toe-in and toe-out gait and with medio-lateral trunk sway at a self-selected speed. Fast walking speed increased the KAdM (17-30%) and flexion moment (32%). A slower walking speed did not decrease the KAdM. Toe-in mainly decreased the KAdM (45%) and the transverse moment (38%) during early stance. Toe-out decreased the KAdM during late stance (56%), but increased the KAdM during early stance and midstance (21-24%), due to decreased endorotation of the hip with knee flexion. Trunk sway decreased the KAdM during early stance and midstance (31-33%). Gait modifications mainly affected the KAdM, but changes in sagittal and transverse knee moments and kinematics were also observed. This indicates that, when estimating knee load, taking only the frontal plane kinetics into consideration may lead to erroneous simplifications. No conclusive beneficial effects were found in any of the gait modifications throughout the entire stance phase.

Gait analysis in children with cerebral palsy via inertial and magnetic sensors

Abstract3D kinematic measurements in children with cerebral palsy (CP) to assess gait deviations can only be performed in gait laboratories using optoelectronic systems. Alternatively, an inertial and magnetic measurement system (IMMS) can be applied for ambulatory motion-tracking. A protocol named Outwalk has recently been developed to measure the 3D kinematics during gait with IMMS. This study preliminary validated the application of IMMS, based on the Outwalk protocol, in gait analysis of six children with CP and one typically developing child. Reference joint kinematics were simultaneously obtained from a laboratory-based system and protocol. On average, the root mean square error (RMSE) of Outwalk/IMMS, compared to the reference, was less than 17° in the transversal plane, and less than 10° in the sagittal and frontal planes. The greatest differences were found in offsets in the knee and ankle rotation, and in the hip flexion. These offset differences were mainly caused by a different anatomical calibration in the protocols. When removing the offsets, RMSE was always less than 4°. Therefore, IMMS is suitable for gait analysis of major joint angles in a laboratory-free setting. Further studies should focus on improvement of anatomical calibrations of IMMS that can be performed in children with CP.

The Effects of Varying Ankle Foot Orthosis Stiffness on Gait in Children with Spastic Cerebral Palsy Who Walk with Excessive Knee Flexion.

Introduction Rigid Ankle-Foot Orthoses (AFOs) are commonly prescribed to counteract excessive knee flexion during the stance phase of gait in children with cerebral palsy (CP). While rigid AFOs may normalize knee kinematics and kinetics effectively, it has the disadvantage of impeding push-off power. A spring-like AFO may enhance push-off power, which may come at the cost of reducing the knee flexion less effectively. Optimizing this trade-off between enhancing push-off power and normalizing knee flexion in stance is expected to maximize gait efficiency. This study investigated the effects of varying AFO stiffness on gait biomechanics and efficiency in children with CP who walk with excessive knee flexion in stance. Fifteen children with spastic CP (11 boys, 10±2 years) were prescribed with a ventral shell spring-hinged AFO (vAFO). The hinge was set into a rigid, or spring-like setting, using both a stiff and flexible performance. At baseline (i.e. shoes-only) and for each vAFO, a 3D-gait analysis and 6-minute walk test with breath-gas analysis were performed at comfortable speed. Lower limb joint kinematics and kinetics were calculated. From the 6-minute walk test, walking speed and the net energy cost were determined. A generalized estimation equation (p<0.05) was used to analyze the effects of different conditions. Compared to shoes-only, all vAFOs improved the knee angle and net moment similarly. Ankle power generation and work were preserved only by the spring-like vAFOs. All vAFOs decreased the net energy cost compared to shoes-only, but no differences were found between vAFOs, showing that the effects of spring-like vAFOs to promote push-off power did not lead to greater reductions in walking energy cost. These findings suggest that, in this specific group of children with spastic CP, the vAFO stiffness that maximizes gait efficiency is primarily determined by its effect on knee kinematics and kinetics rather than by its effect on push-off power. Trial Registration Dutch Trial Register NTR3418

Lateral Trunk Motion and Knee Pain in Osteoarthritis of the Knee: a cross-sectional study

BackgroundPatients with osteoarthritis of the knee may change their gait in an attempt to reduce loading of the affected knee, thereby reducing pain. Especially changes in lateral trunk motion may be potentially effective, since these will affect the position of the centre of mass relative to the knee, enabling minimization of the load on the knee and thereby knee pain. The aim of the study was to test the hypothesis that a higher level of knee pain is associated with higher lateral trunk motion in patients with knee OA.MethodsFifty-two patients with OA of the knee were tested. Lateral trunk motion was measured during the stance phase of walking with an optoelectronic motion analysis system and a force plate. Knee pain was measured with the VAS and the WOMAC pain questionnaire. Regression analyses were performed to assess the relationship between lateral trunk motion and knee pain.ResultsIt was shown that in bivariate analyses knee pain was not associated with lateral trunk motion. In regression analyses, pain was associated with more lateral trunk motion. In addition, more lateral trunk motion was associated with younger age, being female, higher self-reported knee stiffness and higher maximum walking speed.ConclusionPain is associated with lateral trunk motion. This association is weak and is influenced by age, gender, self-reported stiffness and maximum walking speed.

The knee adduction moment measured with an instrumented force shoe in patients with knee osteoarthritis

The external knee adduction moment (KAdM) during gait is an important parameter in patients with knee osteoarthritis (OA). KAdM measurement is currently restricted to instruments only available in gait laboratories. However, ambulatory movement analysis technology, including instrumented force shoes (IFS) and inertial and magnetic measurement systems (IMMS), can measure kinetics and kinematics of human gait free of laboratory restrictions. The objective of this study was a quantitative validation of the accuracy of the KAdM in patients with knee OA, when estimated with an ambulatory-based method (AmbBM) versus a laboratory-based method (LabBM). AmbBM is employing the IFS and a linked-segment model, while LabBM is based on a force plate and optoelectronic marker system. Effects of ground reaction force (GRF), centre of pressure (CoP), and knee joint position measurement are evaluated separately. Twenty patients with knee OA were measured. The GRFs showed differences up to 0.22 N/kg, the CoPs showed differences up to 4 mm, and the medio-lateral and vertical knee position showed differences to 9 mm, between AmbBM and LabBM. The GRF caused an under-estimation in KAdM in early stance. However, this effect was counteracted by differences in CoP and joint position, resulting in a net 5% over-estimation. In midstance and late stance the accuracy of the KAdM was mainly limited by use of the linked-segment model for joint position estimation, resulting in an under-estimation (midstance 6% and late stance 22%). Further improvements are needed in the estimation of joint position from segment orientation.

Reliability and precision of 3D wireless measurement of scapular kinematics

To direct interventions aimed at improving scapular position and motion in shoulder pathologies, a clinically feasible, objective, sensitive and reliable assessment of scapular dyskinesis is needed. The aim of this study is to evaluate the intra- and inter-observer reliability and the precision of 3D scapula kinematics measurement using wireless sensors of an inertial and magnetic measurement system (IMMS). Scapular kinematics during humerus anteflexion and abduction of 20 subjects without shoulder pathologies were measured twice by two observers at two different days, using IMMS. Similar movement patterns and corresponding high intraclass correlation coefficients were found within (intra) and between (inter) observers, especially for scapular retraction/protraction (0.65–0.85) and medio/lateral rotation (0.56–0.91). Lowest reliability and highest difference in range of motion were observed for anterior/posterior tilt. Medio/lateral rotation and anterior/posterior tilt showed a high precision, with standard error of measurement being mostly below 5°. The inter-observer measurements of retraction/protraction showed lowest precision, reflected in systematic differences. This is caused by an offset in anatomical calibration of the sensors. IMMS enables easy and objective measurement of 3D scapula kinematics. Further research in a patient population should focus on clinical feasibility and validity for measurement of scapular dyskinesis. This would include the application of a scapula locator to enhance anatomical calibration.

Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee

Osteoarthritis (OA) of the knee is associated with alterations in gait. As an alternative to force plates, instrumented force shoes (IFSs) can be used to measure ground reaction forces. This study evaluated the influence of IFS on gait pattern in patients with knee OA. Twenty patients with knee OA walked in a gait laboratory on IFS and control shoes (CSs). An optoelectronic system and force plate were used to perform 3D gait analyses. A comparison of temporal-spatial gait parameters, kinematics, and kinetics was made between IFS and CS. Patients wearing IFS showed a decrease in walking velocity and cadence (8%), unchanged stride length, an increase in stance time (13%), stride time (11%) and step width (14%). No differences were found in knee adduction moment or knee kinematics. Small differences were found in foot and ankle kinematics (2–5°), knee transverse moments (5%), ankle frontal (3%) and sagittal moments (1%) and ground reaction force (1–6%). The gait of patients with knee OA was only mildly influenced by the IFS, due to increased shoe height and weight and a change in sole stiffness. The changes were small compared to normal variation and clinically relevant differences. Importantly, in OA patients no effect was found on the knee adduction moment.

Activity patterns of extrinsic finger flexors and extensors during movements of instructed and non-instructed fingers

The fingers of the human hand cannot be controlled fully independently. This phenomenon may have a neurological as well as a mechanical basis. Despite previous studies, the neuromechanics of finger movements are not fully understood. The aims of this study were (1) to assess the activation and coactivation patterns of finger specific flexor and extensor muscle regions during instructed single finger flexion and (2) to determine the relationship between enslaved finger movements and respective finger muscle activation. In 9 healthy subjects (age 22-29), muscle activation was assessed during single finger flexion using a 90 surface electromyography electrode grid placed over the flexor digitorum superficialis (FDS) and the extensor digitorum (ED). We found (1) no significant differences in muscle activation timing between fingers, (2) considerable muscle activity in flexor and extensor regions associated with the non-instructed fingers and (3) no correlation between the muscle activations and corresponding movement of non-instructed fingers. A clear disparity was found between the movement pattern of the non-instructed fingers and the activity pattern of the corresponding muscle regions. This suggests that mechanical factors, such as intertendinous and myofascial connections, may also affect finger movement independency and need to be taken into consideration when studying finger movement.

Can Treadmill Perturbations Evoke Stretch Reflexes in the Calf Muscles

Disinhibition of reflexes is a problem amongst spastic patients, for it limits a smooth and efficient execution of motor functions during gait. Treadmill belt accelerations may potentially be used to measure reflexes during walking, i.e. by dorsal flexing the ankle and stretching the calf muscles, while decelerations show the modulation of reflexes during a reduction of sensory feedback. The aim of the current study was to examine if belt accelerations and decelerations of different intensities applied during the stance phase of treadmill walking can evoke reflexes in the gastrocnemius, soleus and tibialis anterior in healthy subjects. Muscle electromyography and joint kinematics were measured in 10 subjects. To determine whether stretch reflexes occurred, we assessed modelled musculo-tendon length and stretch velocity, the amount of muscle activity, as well as the incidence of bursts or depressions in muscle activity with their time delays, and co-contraction between agonist and antagonist muscle. Although the effect on the ankle angle was small with 2.8±1.0°, the perturbations caused clear changes in muscle length and stretch velocity relative to unperturbed walking. Stretched muscles showed an increasing incidence of bursts in muscle activity, which occurred after a reasonable electrophysiological time delay (163–191 ms). Their amplitude was related to the muscle stretch velocity and not related to co-contraction of the antagonist muscle. These effects increased with perturbation intensity. Shortened muscles showed opposite effects, with a depression in muscle activity of the calf muscles. The perturbations only slightly affected the spatio-temporal parameters, indicating that normal walking was retained. Thus, our findings showed that treadmill perturbations can evoke reflexes in the calf muscles and tibialis anterior. This comprehensive study could form the basis for clinical implementation of treadmill perturbations to functionally measure reflexes during treadmill-based clinical gait analysis.