Joy Liu
Walter and Eliza Hall Institute of Medical Research
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Publication
Featured researches published by Joy Liu.
Blood | 2015
Sarah Kinkel; Roman Galeev; Christoffer Flensburg; Andrew Keniry; Kelsey Breslin; Omer Gilan; Stanley Chun-Wei Lee; Joy Liu; Kelan Chen; Linden Gearing; Darcy Moore; Warren S. Alexander; Mark A. Dawson; Ian Majewski; Alicia Oshlack; Jonas Larsson; Marnie E. Blewitt
Polycomb repressive complex 2 (PRC2) plays a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is targeted to specific genomic loci within HSPCs remains unknown. Here we use short hairpin RNA-mediated knockdown to survey the function of PRC2 accessory factors that were defined in embryonic stem cells (ESCs) by testing the competitive reconstitution capacity of transduced murine HSPCs. We find that, similar to the phenotype observed upon depletion of core subunit Suz12, depleting Jarid2 enhances the competitive transplantation capacity of both fetal and adult mouse HSPCs. Furthermore, we demonstrate that depletion of JARID2 enhances the in vitro expansion and in vivo reconstitution capacity of human HSPCs. Gene expression profiling revealed common Suz12 and Jarid2 target genes that are enriched for the H3K27me3 mark established by PRC2. These data implicate Jarid2 as an important component of PRC2 that has a central role in coordinating HSPC function.
Epigenetics & Chromatin | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine L. Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt
Archive | 2016
Andrew Keniry; Linden Gearing; Natasha Jansz; Joy Liu; Aliaksei Holik; Peter Hickey; Sarah Kinkel; Darcy Moore; Kelsey Breslin; Kelan Chen; Ruijie Liu; Catherine Phillips; Miha Pakusch; Christine Biben; Julie Sheridan; Benjamin T. Kile; Catherine Carmichael; Matthew E. Ritchie; Douglas J. Hilton; Marnie E. Blewitt