Joyce M. Lehner
ZymoGenetics
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Publication
Featured researches published by Joyce M. Lehner.
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 1998
David S. Weigle; Amy M. Hutson; Janet M. Kramer; Margaret G. M. Fallon; Joyce M. Lehner; Si Lok; Joseph L. Kuijper
To determine whether leptin alone accounts for the satiety activity secreted by native adipose tissue, we prepared culture media conditioned by microdissected adipose tissue from overfed Long-Evans rats, fa/ farats, or db/ dbmice ( media A, B, and C, respectively). Medium A significantly suppressed food intake following intracerebroventricular delivery to Long-Evans rats (2-h chow intake = 68 ± 5% of baseline, P< 0.001). Media B and C significantly suppressed food intake following intraperitoneal delivery to ob/ obmice (24-h chow intake = 56 ± 7% of baseline for medium B, P= 0.001; 4-day chow intake = 78 ± 3% of baseline for medium C, P= 0.004). Using a leptin receptor-based bioassay, we determined that the leptin concentration of medium C was 392 ± 18 ng/ml. This concentration was 20-fold lower than the concentration of recombinant murine leptin required to produce a similar degree of feeding suppression following 5 days of administration to ob/ obmice. Neither medium conditioned by adipose tissue from ob/ obmice nor medium conditioned by adipose tissue from fa/ farats and subsequently immunodepleted of leptin had significant satiety activity. We conclude that leptin is necessary but not sufficient to account for the satiety activity of native adipose tissue, perhaps due to the production by adipocytes of a cofactor that augments the ability of leptin to suppress feeding.
Archive | 2004
Wenfeng Xu; Wayne R. Kindsvogel; Yasmin A. Chandrasekher; Stacey R. Dillon; Joyce M. Lehner; Anthony W. Siadak; Pallavur V. Sivakumar; Margaret D. Moore
Archive | 1998
Scott R. Presnell; Teresa Gilbert; Theodore E. Whitmore; Donald C. Foster; Charles E. Hart; Joyce M. Lehner; Theresa Martinez; Ross C. Hoffmann
Archive | 1998
Si Lok; Scott R. Presnell; Anna C. Jelmberg; Teresa Gilbert; Theodore E. Whitmore; Donald C. Foster; Robyn L. Adams; Joyce M. Lehner
Archive | 1998
Paul O. Sheppard; Laura J. Jelinek; Theodore E. Whitmore; Hal Blumberg; Joyce M. Lehner
Archive | 2004
Wenfeng Xu; Wayne R. Kindsvogel; Zhi Chen; Steven D. Hughes; Yasmin A. Chandrasekher; Stacey R. Dillon; Joyce M. Lehner; Anthony W. Siadak; Pallavur V. Sivakumar; Margaret D. Moore
Archive | 2004
Wenfeng Xu; Wayne R. Kindsvogel; Zhi Chen; Steven D. Hughes; Yasmin A. Chandrasekher; Stacey R. Dillon; Joyce M. Lehner; Anthony W. Siadak; Pallavur V. Sivakumar; Margaret D. Moore
Archive | 2009
Wenfeng Xu; Wayne R. Kindsvogel; Yasmin A. Chandrasekher; Stacey R. Dillon; Joyce M. Lehner; Anthony W. Siadak; Pallavur V. Sivakumar; Margaret D. Moore
Archive | 2003
Scott R. Presnell; Teresa Gilbert; Charles E. Hart; Joyce M. Lehner
Archive | 1998
Si Lok; Scott R. Presnell; Anna C. Jelmberg; Teresa Gilbert; Theodore E. Whitmore; Donald C. Foster; Robyn L. Adams; Joyce M. Lehner