Juan Fernández Sánchez

Gibepyrones: α-pyrones from Gibberella fujikuroi

Abstract Six α-pyrones, called gibepyrones A-F, were identified in three different culture media of G. fujikuroi (IMI 58289). Their structures were determined using both spectroscopic techniques and chemical synthesis. Their antimicrobial activity has been screened.

Fusarin C and 8Z-fusarin C from Gibberella fujikuroi

Abstract Fusarin C, (8 Z)-fusarin C, cyclonerodiol and a mixture of fatty acids esters were isolated from cultures of Gibberella fujikuroi. The structures of fusarin C and (8 Z)-fusarin C were determined by spectroscopy. The all-E isomer of fusarin C predominates in strain ATCC 38932, whereas the 8Z isomer predominates in strain IMI 58289. This is the first report of (8Z)-fusarin C as a natural product. Fusarin concentrations in the culture medium and in the mycelia vary widely depending on the strain, the medium and the temperature of incubation. Strains with a high fusarin production are recognized by a yellowish colour in the mycelium or the culture medium. From strain IMI58289 we have isolated mutants that contain up to 8 mg (8Z)-fusarin C per g dry wt.

Terpenoids and sterols from the wood of Abies pinsapo

Abstract From the neutral fraction of the hexane extract of the wood of Abies pinsapo 11 sesquiterpenoids, seven diterpenoids, three triterpenoids and two sterols have been identified. Three of them are new natural products: 3β-hydroxy-13-epimanool, (23 R ,25 R )-3α-methoxy-9,19-cyclo-9β-lanostan-26,23-olide and (22 S )-5α-ergostane-3α,22-diol. Their structures were established by spectroscopic methods and chemical correlations.

Diterpenoids and cyclolanostanolides from Abies marocana

Abstract From the neutral fraction of a hexane extract of the leaves of Abies marocana, eight sesquiterpene hydrocarbons, 10 diterpenoids, and two triterpenoids have been identified. Seven are new natural products: labda-7,12Z,14-triene, labda-8(17),12Z,14-triene, labda-7,11E,13Z-triene and labda-8(17),11E,13Z-triene, 7α,18-dihydroxyabieta-8,11,13-triene, (23R)-3α-hydroxy-9,19-cyclo-9β-lanostan-26,23-olide and (23R)-3α-hydroxy-9,19-cyclo-9β-lanost-24-en-26,23-olide. Their structures have been established by spectroscopic methods and chemical correlations.

Endoperoxide diterpenoids and other constituents from Abies marocana

Abstract From the acid fraction of the hexane extract of the needles of Abies marocana three endoperoxide diterpenoids, methyl 12α-hydroxyabietate and a triterpenoid, in addition to other resin acids have been isolated.

Oxygenated sesquiterpenes from the wood of Juniperus oxycedrus

Abstract Twenty-one sesquiterpene components were identified in the essential oil from the wood of Juniperus oxycedrus . Three of these, as well as the preliminary reported 14-hydroxy-9- epi -β-caryophyllene, are new natural products.

Resorcinol derivatives and other components of Ononis speciosa

Abstract From the flowers of Ononis speciosa , flavonoids, terpenoids, sterols phenolic acids, cardol monoene and methyl 6-(pentadec-8Z-enyl)-2,4-dimetoxybenzoate, as well as the three new compounds: 5-(10)-acetoxy-pentadec-8Z-enyl)-resorcinol, methyl 6-(10)-acetoxy-pentadec-8Z-enyl)-2,4-dimetoxybenzoate and 6″-O-acetylononin have been isolated.

Terpenoids of the wood of Abies marocana

We have characterized seven sesquiterpen- oids, five triterpenoids, four of them juvenile hormone analogues, 14 diterpenoids, five triterpenoids and two sterols, besides a number of fatty acids. Compounds 2, 5, 6 and g are new natural products, and 3 and 4 are described for the first time in the genus

HOMODITERPENES FROM THE ESSENTIAL OIL OF TANACETUM ANNUUM

An investigation of the essential oil from the flowers of Tanacetum annuum led to the identification of 43 components, two of them having a homoditerpene skeleton. Five of these substances are new natural products.

Fulvene lactones from Tanacetum annuum

Abstract An investigation of Tanacetum annuum afforded two new guaianolides, tannunolides A and B, sesquiterpene lactones with a fulvene structure, elucidated by spectroscopic methods and chemical transformations.