Juan M. Trujillo

Lignans from Justicia hyssopifolia

Abstract Two new lignans named J 1 and J 2 have been isolated from leaves of Justicia hyssopifolia , the latter as a β- d -glucoside, together with the known lignans helioxanthin, justicidin E, gadain, cubebin and sesamin. The structures of the novel compounds have been elucidated by spectroscopical methods and chemical transformations.

Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii

The paper deals with the effects of a glycosidal extract of Digitalis heywoodii, ssp. of Digitalis purpurea L., (Schrophulariaceae) grown in Badajoz (Spain), on isolated cardiac auricle of rabbits, urinary excretion of rats, as well as its emetic effect in pigeons. These effects using vehicle (propylene glycol-ethanol-water, 40:10:50) and digoxin as standards are presented. The extract at concentrations of 20 and 40 microg/ml produced an increase in the contraction force of auricles in a dose-dependent way. At doses of 15 and 30 mg/kg a slight diuretic and natriuretic effect was observed. The active dose range for emesis was 0.5-4 mg/kg and a decrease of the emesis time within 10 min of injection in dose-dependent manner was obtained. The pharmacological activity of the extract is related to gitoxin derivatives (digitalinum verum and strospeside), the most abundant compounds obtained from the leaves of Digitalis purpurea spp. heywoodii.

A secoiridoid glucoside from Jasminum odoratissimum

A new secoiridoid glucoside, 10-acetoxyoleoside dimethyl ester, together with the known 10-hydroxyoleoside dimethyl ester was isolated from leaves of Jasminum odoratissimum. The structures of these compounds have been characterized on the basis of spectroscopic evidence.

Lignans from Apollonias barbujana

Abstract Two new lignans, 2,3- bis [(4-hydroxy-3,5-dimethoxyphenyl)-methyl]-1,4-butanediol and demethylpiperitol, together with three already-known ones, have been isolated from the leaves of Apollonias barbujana (Lauraceae). The structures were fully characterized by spectroscopical methods. The known lignans were identified as sesamin, syringaresinol and the neolignan, dihydro-dehydrodiconiferyl alcohol.

Synthesis of new aryltetralin lignans

Abstract Cyclization with CF3CO2H of the dibenzyllactone compounds 3 and 4 afforded the aryltetralin derivatives 6a and 6b , epimers at the carbon α to the lactonic carbonyl group, in which the aryl substituent group is in the α-axial position. 1H NMR data assignments of the compounds obtained are also given.

Iridoids and secoiridoids from Oleaceae

Abstract The iridoid and secoiridoid derivatives of Oleaceae have been grouped regarding structural similarities. The biosynthetic routes leading to these compounds and their most relevant biological activities, described up to now, have also been reviewed.

New C13-Norisoprenoids from Apollonias barbujana

Abstract Two new C13-norisoprenoids, (3S,4S,5R,6R)*−3,4,6-tri-hydroxy-5,6-dihydro-β-ionol (1) and (3S,5R,6R)*-3,5,6-trihydroxy-5,6-dihydro-β-ionol (2), were isolated from the leaves of Apollonias barbujana (Lauraceae). Their structures were determined on the basis of spectroscopic analysis.

Secoiridoid Glucosides and Iridoids From Jasminum Odoratissimum

Abstract Two new secoiridoid glucosides, trans- 10-(cinnamoyloxy) oleoside dimethylester (methyl jasminoside) and cis-10-(cinnamoyloxy) oleoside monomethyl ester, and two new iridoids, 1α-and 1β-, 7-dehydrologanetin, together with the known iridoid jasminoside were isolated from leaves of Jasminum odoratissimum. the structures of these compounds have been characterised on the basis of spectroscopic evidence.