Juan S. Lasa

Mo1574 Increased Risk of Colonic Neoplasia in Patients With Sporadic Duodenal Adenomas

Mo1573 Prevalence of Polyps, Adenomas, Advanced Lesions and Adenocarcinoma in 45 to 49 YearOld Patients Luis E. Caro, Liliana M. Correa*, Sandra Canseco, Carolina Bolino, Cecilio L. Cerisoli Gedyt, Buenos Aires, Argentina; Gastroenterology Hospital Dr Carlos Bonorino Udaondo, Buenos Aires, Argentina Introduction: Colon rectal cancer (CRC) can be prevented and cured if it is early diagnosed. Colonoscopy is the first-line procedure for screening CRC in average risk population. In 2002, Imperiale and collaborators reported that adenomas and advanced adenomas presented in 8.5% and 3.5%, respectively, among persons 40 to 49 years of age. At this moment no recommendations for CRC screening in this population have been made. Objective: To estimate the prevalence of polyps, adenomas, advanced lesions and adenocarcinoma in 45 to 49 yearold patients. Materials and Methods: We included consecutive adults between the ages 45 and 49 years who performed colonoscopy because of gastrointestinal signs or symptoms. We excluded patients at high risk for CRC, incomplete procedures and/ or evidence of colonic tumor diagnosed by other methods. The study was conducted in a gastroenterology and endoscopy ambulatory center in Buenos Aires, Argentina, between September 2010 and October 2011. Design: Descriptive, prospective and cross sectional study. Interventions: Polyethylene glycol (PEG) lavage solution or phosphates, with or without bisacodyl were used for bowel preparation. Colonoscopies were performed under sedation with Olympus 160/180 series equipment. Biopsies were evaluated by pathologists specialized in gastroenterology. Indication for colonoscopy was registered. The protocol was approved by local IRB. Statistical analysis: VCCstat 2.0. 95% CI were estimated. Results: 814 patients were evaluated. 764 were included. 57% (440/764) were women; average age was 47 years.1.a) The global prevalence of polyps was 160/764 (20%; 95 CI 18-24); 71/440 (16%; 95 CI 13-20) in women and 89/324 (27%; 95 CI 22-32) in men. 1.b) The global prevalence of adenomas was 107/764 (14%; 95 CI 11-16%), 59/324 (18%; 95 CI 14-22) in men and 48/440 (11%; 95 CI 8-14) in women; 1.c) The global prevalence of advanced adenomas was 39/764 (5%;95 CI 4-7) and of adenocarcinoma was 2/764 (0.1%; 95 CI 0-0, 7). The most common indications for colonoscopy were proctorrhagia, abdominal pain and altered bowel habits. Conclusions: The prevalence of lesions in this population is lower than average risk population and it is similar to the information reported internationally. At the moment we do understand that there is no evidence to indicate CRC screening in 45 to 49 individuals . Research on metabolic and epidemiological factors are needed to evaluate the biological behavior of CRC in young individuals.