Juan Sebastián López-Arranz

Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance.

The prognostic and clinicopathologic significance of cyclin D1 and Ki-67 expressions was studied in oral squamous cell carcinomas. We performed an immunohistochemical study to determine the level of expression of cyclin D1 and Ki-67 labelling index in tumor specimens obtained from 35 patients, of whom 14 died as a result of recurrent disease, and 20 were free of recurrence at the end of the follow-up period. Overexpression of cyclin D1 was significantly associated with regional lymph node metastases (P=0.00005) and advanced tumor stage (P=0.0007). The relative risk for nodal metastases in the cases that overexpressed cyclin D1 was 2.6. The Ki-67 labelling index was significantly (P=0.001) higher in tumors with poor histologic grade of differentiation. Our results showed that cyclin D1 is a useful prognostic factor, and suggested it could be a marker to help determine the appropriate treatment for patients with oral squamous cell carcinoma. Cyclin D1 and Ki-67 overexpression were positively correlated.

Granular-cell tumours: an immunohistochemical study

The granular cell tumour (myoblastoma, Abrikosoffs tumour) and the congenital epulis in newborns (Neumann tumour) are two lesions rarely found in the oral cavity, whose histogenetic origin is highly controversial. This work analyses using immunohistochemical techniques 15 cases of myoblastomas and two of congenital epulis with different mono- and poly-clonal antibodies. Positive immunostaining was found for S-100 protein and neuron-specific enolase in all the cases of myoblastoma, and for vimentin and carcinoembryonic antigen in some cases. No immunoreactivity was observed for any of the other 13 antibodies used in congenital epulis.

Bone regeneration after radicular cyst removal with and without guided bone regeneration.

In order to determine the degree of bone regeneration after removal of radicular cysts using guided bone regeneration (GBR), a prospective, controlled and randomized clinical study was performed. Thirty patients with radicular cysts were divided into three groups. One group, the control group (n=10 patients), was treated by enucleation and primary closure. The other two groups were treated by enucleation and primary closure but GBR was used in addition, using a resorbable membrane (n=10) and a nonresorbable membrane (n=10). The membranes were fixed with nonresorbable Memfix System screws. The residual volume and the density of the newly formed tissue was measured by computer-assisted tomography and computer-assisted digital image analysis before enucleation and three and six months postoperatively. No statistical significance was found in density and residual volume between the three treatment groups after six months. These results suggest that GBR using membranes does not contribute to increased bone regeneration.

Chronic sclerosing sialadenitis of the parotid gland

Chronic sclerosing sialadenitis (Küttners tumor) is a benign and chronic inflammatory condition of the submandibular gland that clinically cannot be easily distinguished from salivary malignant neoplasia. This is a report of a case of chronic sclerosing sialadenitis located as a solitary mass in an accessory parotid gland.

Pleomorphic adenoma of the salivary glands: Prospective clinicopathologic and flow cytometric study

Primary surgery is the appropriate treatment for most pleomorphic adenomas of the salivary glands. However, no reliable criteria have been established to predict tumors with aggressive features.

Expression of matrix metalloproteinase-9 in high-grade salivary gland carcinomas is associated with their metastatic potential.

Objective: The aim of this study was to investigate the role of matrix metalloproteinase (MMP)‐9 protein in high‐grade malignant tumors of salivary gland origin as well as its utility as a prognostic marker.

Preservation of the inferior alveolar nerve in the surgical approach to cancer of the posterior oral cavity

Tl and T2 cancers of the buccal mucosa are usually amenable to simple perioral excisi0n.l However, T3 and T4 buccal cancers and retromolar trigone cancers may require a lip-splitting incision and lower cheek flap for exposure and obtaining adequate oncologic margins.’ This approach sacrifices the mental nerve, leading to anesthesia of the lip and mental area.2 Transposition of the inferior alveolar nerve has been performed to facilitate orthognathic surgery3 and the placement of implants.* To our knowledge, inferior alveolar nerve transposition has not been done in oncologic procedures. The purpose of this report is to present a modification of the classic approach to posterior oral cancers that preserves the inferior alveolar nerve.

I Conferencia Nacional de Consenso sobre el Injerto Óseo del Seno Maxilar

Resumen Objetivo El objetivo de la I Conferencia Espanola de Consenso sobre el Injerto Oseo Sinusal era intentar llegar a puntos de acuerdo sobre las principales controversias de esta tecnica, aplicada de forma muy variada y con el empleo de materiales muy diversos, y conseguir plasmar los mismos en un documento resumen consensuado por todos los autores. Material y metodo Durante los dias 17 y 18 de octubre de 2008 se celebro en Oviedo la citada conferencia, auspiciada por la Sociedad Espanola de Cirugia Oral y Maxilofacial. En ella se dieron cita un total de 50 ponentes de reconocido prestigio nacional e internacional que repasaron en 6 mesas de trabajo las principales controversias sobre los injertos oseos sinusales. Tras las conferencias de los ponentes, los moderadores establecian las principales conclusiones de cada mesa y se abria un turno de debate donde participaban todos los asistentes. Resultado Este documento y sus conclusiones emanan de las presentaciones realizadas por los ponentes y de las deliberaciones y acuerdos de cada mesa de trabajo. Ambos han sido aprobados tras varias correcciones por todos los autores antes de ser enviados para su publicacion. Ademas, han obtenido el reconocimiento cientifico oficial de la Sociedad Espanola de Cirugia Oral y Maxilofacial y deben servir como base para futuros estudios y reuniones cientificas. Conclusiones El objetivo fundamental cuando se realiza un injerto oseo sinusal es la formacion de hueso vital en el seno maxilar, para conseguir la supervivencia a largo plazo de los implantes tras su carga protesica. Para ello, la tecnica y la secuencia de tratamiento deben orientarse a conseguir resultados predecibles y estables en el tiempo, aunque esto suponga un mayor tiempo de espera hasta la colocacion de la protesis. La estabilidad inicial del implante es el factor clave para la osteointegracion y debe ser el principal criterio para indicar implantes simultaneos o diferidos en el seno maxilar.