Juanelle Little Lambert
Eastman Chemical Company
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Publication
Featured researches published by Juanelle Little Lambert.
Journal of Pharmacy and Pharmacology | 2009
Sandra Klein; Michael F. Wempe; Thomas Zoeller; Norma Lindsey Buchanan; Juanelle Little Lambert; Michael G. Ramsey; Kevin J. Edgar; Charles Michael Buchanan
Objectives Glyburide, an important drug for type 2 diabetes, has extremely poor aqueous solubility and resulting low bioavailability. This study describes the ability of hydroxybutenyl‐β‐cyclodextrin (HBenBCD) to form complexes with glyburide, with enhanced solubility and dissolution rate in vitro.
Carbohydrate Research | 2002
Charles Michael Buchanan; Susan R. Alderson; Curtis D. Cleven; Daniel Wayne Dixon; Róbert Iványi; Juanelle Little Lambert; Douglas Lowman; Rick J. Offerman; József Szejtli; Lajos Szente
We have examined the synthesis of hydroxybutenyl cyclomaltooligosaccharides (cyclodextrins) and the ability of these cyclodextrin ethers to form guest-host complexes with guest molecules. The hydroxybutenyl cyclodextrin ethers were prepared by a base-catalyzed reaction of 3,4-epoxy-1-butene with the parent cyclodextrins in an aqueous medium. Reaction byproducts were removed by nanofiltration before the hydroxybutenyl cyclodextrins were isolated by co-evaporation of water-EtOH. Hydroxybutenyl cyclodextrins containing no unsubstituted parent cyclodextrin typically have a degree of substitution of 2-4 and a molar substitution of 4-7. These hydroxybutenyl cyclodextrins are randomly substituted, amorphous solids. The hydroxybutenyl cyclodextrin ethers were found to be highly water soluble. Complexes of HBen-beta-CD with glibenclamide and ibuprofen were prepared and isolated. In both cases, the guest content of the complexes was large, and a significant increase in the solubility of the free drug was observed. Dissolution of the complexes in pH 1.4 water was very rapid, and significant increases in the solubility of the free drugs were observed. Significantly, after reaching equilibrium concentration, a decrease in the drug concentration over time was not observed.
Archive | 2003
Charles Michael Buchanan; Norma Lindsey Buchanan; Kevin Joseph Edgar; Juanelle Little Lambert
Archive | 2012
Charles Michael Buchanan; Norma Lindsey Buchanan; Susan Northrop Carty; Chung-Ming Kuo; Juanelle Little Lambert; Jessica Dee Posey-Dowty; Thelma Lee Watterson; Matthew Davie Wood; Michael Orlando Malcolm; Margaretha Soderqvist Lindblad
Archive | 2002
Charles Michael Buchanan; Steven N. Falling; Juanelle Little Lambert; Shannon E. Large; Jozsef Szejtli; Lajos Szente; László Jicsinszky
Journal of Pharmaceutical Sciences | 2006
Charles Michael Buchanan; Norma Lindsey Buchanan; Kevin Joseph Edgar; Juanelle Little Lambert; Jessica Dee Posey-Dowty; Michael G. Ramsey; Michael F. Wempe
Archive | 2005
Charles Michael Buchanan; Norma Lindsey Buchanan; Juanelle Little Lambert; Jessica Dee Posey-Dowty
Archive | 2006
Charles Michael Buchanan; Norma Lindsey Buchanan; Juanelle Little Lambert
Archive | 2003
Charles Michael Buchanan; Steven N. Falling; Juanelle Little Lambert; Shannon E. Large; Jozsef Szejtli; Lajos Szente; László Jicsinszky
Archive | 2008
Charles Michael Buchanan; Norma Lindsey Buchanan; Robert Thomas Hembre; Juanelle Little Lambert