Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Judah Folkman is active.

Publication


Featured researches published by Judah Folkman.


Growth Factors Journal | 1996

Human Betacellulin, a Member of the EGF Family Dominantly Expressed in Pancreas and Small Intestine, is Fully Active in a Monomeric Form

Masaharu Seno; Hiroko Tada; Megumi Kosaka; Reiko Sasada; Koichi Igarashi; Yuen Shing; Judah Folkman; Masakazu Ueda; Hidenori Yamada

Betacellulin (BTC) was found to be expressed mainly in human pancreas and small intestine. This finding suggests that BTC possesses some specific function distinguished from the other members of epidermal growth factor (EGF) family. To clarify this function, the released form of human BTC has been expressed in E.coli, purified, and characterized. The recombinant human BTC was produced as an inclusion body. This material was dissolved in guanidine-HCl under reducing conditions, refolded, and purified through sequential liquid chromatography. Purified BTC was electrophoresed under reducing conditions and a molecular size of 18 kDa was determined, which is the supposed size of a dimer of the peptide. However, chemical analysis failed to show a covalently linked dimer. The molecular mass of BTC analyzed by mass spectrometry revealed it to be 9 kDa, which is consistent with theoretical value for a monomer. Recombinant BTC showed growth promoting activity for mouse fibroblasts and rat aortic smooth muscle cells which was equivalent to EGF On the other hand, BTC was found to exhibit a growth inhibitory effect on the cells overexpressing EGF receptor.


Archive | 1990

Magnetically modulated polymeric drug release system

Judah Folkman; Robert Langer; Dean S.T. Hsieh


Archive | 1988

Method and a pharmaceutical composition for the inhibition of angiogenesis

Judah Folkman; Takeshi Fujita; Donald Ingber; Tsuneo Kanamaru


Archive | 1988

Angiostatic collagen modulators

Judah Folkman; Donald Ingber


Archive | 1989

Fumagillin as angiostatic agent

Judah Folkman; Donald Ingber; Takeshi Fujita; Tsuneo Kanamaru


Archive | 2016

Magnetic modulation of release of macromolecules from polymers (sustained release/drug delivery system/diabetes/hormones/controlled release)

Dean S.T. Hsieh; Robert Langer; Judah Folkman


Archive | 1998

Methoden zur regulierung der grösse und des wachstums von durchblutetem normalem gewebe

Judah Folkman; Robert Langer; Maria Rupnick


Archive | 1998

Methods for regulation of the size and growth of normal vascularized tissue

Judah Folkman; Robert Langer; Maria Rupnick


Archive | 1989

Angiogenesis inhibitor comprising fumagillin

Judah Folkman; Donald Ingber; Takeshi Fujita; Tsuneo Kanamaru


Archive | 1989

Fumagillin als angiostatisches Mittel. Fumagillin as angiostatic agent.

Judah Folkman; Donald Ingber; Takeshi Fujita; Tsuneo Kanamaru

Collaboration


Dive into the Judah Folkman's collaboration.

Top Co-Authors

Avatar

Donald Ingber

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Takeshi Fujita

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Tsuneo Kanamaru

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Robert Langer

Massachusetts Institute of Technology

View shared research outputs
Top Co-Authors

Avatar

Dean S.T. Hsieh

Massachusetts Institute of Technology

View shared research outputs
Top Co-Authors

Avatar

Maria Rupnick

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge