Judit Hohmann

Jatrophane diterpenoids from Euphorbia peplus

From the pro-inflammatory active extract of Euphorbia peplus, a new diterpene polyester (1) based on the jatrophane skeleton was isolated together with the known compounds 2-5. The irritant activities of some jatrophane diterpenes (2, 3 and 6-9) were also investigated: only compound 2 was found to exert a weak pro-inflammatory activity on mouse ear.

STRUCTURAL CHARACTERIZATION AND DYNAMIC NMR STUDIES OF A NEW PERACYLATED MACROCYCLIC DITERPENE

A heptaester of a new diterpene alcohol was isolated from the dichloromethane extract of the whole plant of Euphorbia esula L. A detailed NMR and mass spectral analysis revealed that its structure is (E)‐(2R*, 3R*, 4S*, 5R*, 7S*, 8R*, 9S*, 13R*, 15R*)‐2,3,5,8,9‐pentaacetoxy‐7‐isobutanoyloxy‐14‐oxojatropha‐6(17),11‐diene. Its conformation was studied in three different solutions. The temperature dependence of the spectral parameters revealed conformational changes through internal rotation of the macrocycle part of the molecule. Copyright

Jatrophane diterpenoids from Euphorbia esula

Two new jatrophane diterpenoids, esulatin D and E, have been isolated from the dichloromethane extract of the whole, undried plant of Euphorbia esula. The structures have been assigned on the basis of spectral analysis, including 2D NMR experiments.

Sesquiterpene esters from Euonymus nanus

Abstract Three new sesquiterpene polyol esters were isolated from the fruit of Euonymus nanus. Their structures were elucidated by various spectroscopic methods to be 1β-isobutyryloxy-2β,6α,15-triacetoxy-9α-benzoyloxy-4α-hydroxydihydro-β-agarofuran, 1β-(2-methyl)butyryloxy-2β,6α,15-triacetoxy-9α-benzoyloxy-4α-hydroxydihydro-β-agarofuran and 1β,2β,6α,15-tetraacetoxy-9α-benzoyloxy-4α-hydroxydihydro-β-agarofuran.

Two sesquiterpene pyridine alkaloids from Euonymus sachalinensis

Abstract A new sesquiterpene pyridine alkaloid and a known compound, evonolin, were isolated from the fruits of Euonymus sachalinensis . Their structures wer

A sesquiterpene polyol ester from Euonymus sachalinensis

Abstract A new sesquiterpene ester, euosachalidin-A, was isolated from the fruits of Euonymus sachalinensis , and its structure was elucidated on the basis of spectral analysis. Complete assignment of all 1 H and 13 C NMR chemical shifts was achieved via 1 H 1 H COSY, 1 H 13 C COSY, NOESY and COLOC experiments.

Serrulatin A and B, New Diterpene Polyesters from Euphorbia serrulata

Abstract Two new diterpene polyesters, serrulatin A (1) and B (2), were isolated from an n-hexane extract of the whole, undried plant of Euphorbia serrulata. The structures were elucidated by various spectroscopic methods, including ESI-MS, IR, UV, 1D and 2D NMR techniques and X-ray crystallography. Serrulatin A contains a hitherto unknown heterocyclic ring system, while serrulatin B is a diterpene, which can be formally derived from 1 by ring opening.