Jue Zhou

Electro-Acupuncture in Relieving Labor Pain

To study the efficacy of electro-acupuncture for the relief of labor pain, and to build a better understanding of how electro-acupuncture might influence the neuroendocrine system, 36 primiparas were randomly divided into an electro-acupuncture group and a control group. Assessments of pain intensity and degree of relaxation during labor were analyzed. The differences between the electro-acupuncture group and the control group on the concentration of β-endorphin (β-EP) and 5-hydroxytryptamine (5-HT) in the peripheral blood were compared. The electro-acupuncture group was found to exhibit a lower pain intensity and a better degree of relaxation than the control group (p = 0.018; p = 0.031). There existed a significant difference in the concentration of β-EP and 5-HT in the peripheral blood between the two groups at the end of the first stage (p = 0.037; p = 0.030). Electro-acupuncture was found to be an effective alternative or complementary therapy in the relief of pain during labor. The benefit of electro-acupuncture for relieving labor pain may be based on the mechanism of producing a synergism of the central nervous system (CNS) with a direct impact on the uterus through increasing the release of β-EP and 5-HT into the peripheral blood.

Acupuncture and Auricular Acupressure in Relieving Menopausal Hot Flashes of Bilaterally Ovariectomized Chinese Women: A Randomized Controlled Trial

The objective of this study is to explore the effects of acupuncture and auricular acupressure in relieving menopausal hot flashes of bilaterally ovariectomized Chinese women. Between May 2006 and March 2008, 46 bilaterally ovariectomized Chinese women were randomized into an acupuncture and auricular acupressure group (n = 21) and a hormone replacement therapy (HRT) group (Tibolone, n = 25). Each patient was given a standard daily log and was required to record the frequency and severity of hot flashes and side effects of the treatment felt daily, from 1 week before the treatment started to the fourth week after the treatment ended. The serum levels of follicle stimulating hormone (FSH), LH and E2 were detected before and after the treatment. After the treatment and the follow-up, both the severity and frequency of hot flashes in the two groups were relieved significantly when compared with pre-treatment (P <  .05). There was no significant difference in the severity of hot flashes between them after treatment (P >  .05), while after the follow-up, the severity of hot flashes in the HRT group was alleviated more. After the treatment and the follow-up, the frequency of menopausal hot flashes in the HRT group was reduced more (P <  .05). After treatment, the levels of FSH decreased significantly and the levels of E2 increased significantly in both groups (P <  .05), and they changed more in the HRT group (P <  .05). Acupuncture and auricular acupressure can be used as alternative treatments to relieve menopausal hot flashes for those bilaterally ovariectomized women who are unable or unwilling to receive HRT.

Effects of Acupuncture on the Outcomes of In Vitro Fertilization: A Systematic Review and Meta-Analysis

OBJECTIVES The objective of this article was to conduct a systematic review with meta-analysis of the trials of acupuncture during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment on the outcomes of clinical pregnancy, biochemical pregnancy, ongoing pregnancy, implantation rate, live birth, and miscarriage. SEARCH STRATEGY The search was conducted by using MEDLINE(®), SCISEARCH, the Cochrane Menstrual Disorders and Subfertility Group trials register, AMED, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Wanfang Database, China Academic Journal Electronic full text Database in China National Knowledge Infrastructure, Index to Chinese Periodical Literature, ISI Proceedings for conference abstracts, and ISRCTN Register and Meta-register for randomized controlled trials. DATA COLLECTION AND ANALYSIS Study selection, quality appraisal, and data extraction were performed independently and in duplicate. The measures of treatment effect were the pooled relative risks (RR) of achieving clinical pregnancy, biochemical pregnancy, ongoing pregnancy, implantation rate, live birth, or miscarriage for women in the acupuncture group compared with women in the control group. RESULTS Using the random-effects model, pooling of the effect estimates from all of the 17 trials showed no significant difference in the clinical pregnancy outcome between the acupuncture and the control groups (RR=1.09, 95% confidence interval (CI) 0.94-1.26, p=0.25). No significant differences in the biochemical pregnancy, ongoing pregnancy, implantation rate, live birth, or miscarriage outcomes were found between the acupuncture and the control groups (biochemical pregnancy: RR=1.01, 95% CI 0.84-1.20, p=0.95; ongoing pregnancy: RR=1.20, 95% CI 0.93-1.56, p=0.16; implantation rate: RR=1.22, 95% CI 0.93-1.62, p=0.16; live birth: RR=1.42, 95% CI 0.92-2.20, p=0.11; miscarriage outcomes: RR=0.94, 95% CI 0.67-1.33, p=0.74). CONCLUSIONS No significant benefits of acupuncture are found to improve the outcomes of IVF or ICSI.

Potential genotoxicity of traditional chinese medicinal plants and phytochemicals: an overview.

In the last decades, cases of poisoning due to herbal medicines have occurred in many countries; Chinese herbal medicines (CHMs) are occasionally involved. The experience gained from traditional use is efficient to detect immediate or near‐immediate relationship between administration and toxic effects but is quite unlikely to detect medium‐ to long‐term toxicities; thorough investigations of herbal medicines (toxicity assessments, active pharmacovigilance) appear then essential for their safe use. Genotoxicity is an especially insidious toxicity that may result in carcinoma development years after exposure; it can arise from multiple compounds, with or without metabolic activation. The present work reviews traditional CHMs and phytochemicals that have been shown to present a genotoxic hazard. Copyright

Acupuncture for Perimenopausal Symptoms in Women who Underwent Oophorectomy – a Comparative Study

Objective: To explore the effects of acupuncture on perimenopausal symptoms in women who underwent oophorectomy. Methods: 67 women who had undergone oophorectomy were divided into an acupuncture group (n = 36) and a comparison group (n = 31) according to their wishes. The first group was treated by acupuncture and the latter group by Livial®. Clinical symptoms were assessed by the modified Kupperman index. The levels of venous blood serum ß-endorphin (ß-EP), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and the maturation index (MI) of vaginal epithelial cells were assessed. Results: There were no significant group differences for the MI of vaginal exfoliative cells nor for the levels of FSH, LH and E2 after treatment (p > 0.05), but Kupperman scoring and the levels of ß-EP differed significantly between the acupuncture and the Livial group (p < 0.05). No side-effects were reported in either group. Conclusion: Acupuncture results in a significant improvement in perimenopausal symptoms in women who have had an oophorectomy. Acupuncture performs as well or better than Livial. Yet, this result may have been influenced by a potential bias and the small sample size.

Chinese Medicinal Herbs in Relieving Perimenopausal Depression: A Randomized, Controlled Trial

OBJECTIVE To explore the effects of GengNianLe (GNL, also called perimenopausal depression relieving formula), a defined formula of Chinese medicinal herbs in relieving perimenopausal depression in Chinese women. METHODS Between September 2004 and April 2008, 47 Chinese women were randomized into a GNL group (n = 21) and a control group which received tibolone (n = 26) using a randomization chart. Depression was rated with the 24-item Hamilton Depression Scale (HAMD). The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E(2)) were detected before and after the treatment. RESULTS After 12 weeks of treatment, HAMD scores in both groups decreased significantly (p < 0.05) with no significant difference between the groups (p > 0.05). The levels of FSH decreased significantly and the level of E(2) increased significantly in both groups, and they changed more in the control group. No side-effect of treatment was reported in either group during treatment. CONCLUSIONS The Chinese medicinal formula GNL showed promise in relieving perimenopausal depression and merits further study.

Auricular acupressure may improve absorption of flavanones in the extracts from Citrus aurantium L. in the human body.

OBJECTIVE To explore whether auricular acupressure could improve the absorption of flavanones in the extracts from Citrus aurantium L. in the human body. METHODS Ten (10) healthy male volunteers were randomly divided into two groups. Group A was treated with the combination of oral administration of C. aurantium L. extracts and auricular acupressure. Group B was treated only with the oral administration of C. aurantium L. extracts in the same dosage as Group A. After 7 days of treatment, the plasma concentration of naringenin and hesperetin of the two groups were determined using high-performance liquid chromatography. RESULTS The plasma concentration of naringenin and hesperetin in Group A were significantly higher than Group B. CONCLUSIONS Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L. in the human body.

Acupuncture May Improve the Absorption of Baicalin from the Extracts of Scutellaria baicalensis Georgi in Rats with Pelvic Inflammation

The aim of the present study was to explore whether acupuncture may improve the absorption of baicalin from the extracts of Scutellaria baicalensis Georgi in rats with pelvic inflammation. 24 female Sprague-Dawley (SD) rats were randomly divided into groups A (a combination of oral administration of Scutellaria baicalensis Georgi extracts and acupuncture), B (oral administration of Scutellaria baicalensis Georgi extracts), C (model group) and D (normal control group), with 6 rats in each group. After treatment, the plasma concentration of baicalin was determined using high performance liquid chromatography (HPLC), the serum levels of tumor necrosis factor-alpha (TNF-α) and Interleukin 6 (IL-6) were detected with enzyme-linked immunosorbent assay (ELISA). The results showed that the plasma concentration of baicalin in group A was significantly higher than in group B, and the serum levels of TNF-α and IL-6 in group A were significantly lower than in group B. This indicates that acupuncture at certain acupoints may significantly improve the curative effects of Scutellaria baicalensis Georgi in rats with pelvic inflammation by enhancing the absorption of baicalin from the Scutellaria baicalensis Georgi extracts.

Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats.

The aim of this research was to explore whether acupuncture could improve the absorption of baicalin from extracts of Scutellaria baicalensis Georgi in normal rats. Twenty male Sprague–Dawley (SD) rats were divided randomly into two groups. Group A was treated with a combination of oral administration of Scutellaria baicalensis Georgi extracts and acupuncture. Group B was treated only with oral administration of Scutellaria baicalensis Georgi extracts, in the same dosage as Group A. After treatment, the plasma concentration of baicalin was detected and pharmacokinetic analysis was conducted using high performance liquid chromatography (HPLC). The results showed that the plasma concentration of baicalin in Group A was significantly higher than in Group B, and that acupuncture at the acupoints Jizhong (Du6), Dazhui (Du14) and Zhongwan (Ren12) made the plasma concentration‐time course of baicalin produce a bimodal phenomenon, increased the area under the curve (AUC) and slowed the elimination of baicalin, thus significantly improving the absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. Copyright

Treating Ovarian Cysts with Chinese Herbs: A Case Report

We report the case of a female patient suffering from continuous lower abdominal distending pain from an ovarian cyst for 1 year. The sonography taken on February 12, 2008 showed on the right ovary in the frontal position a cystic mass of 43.0 × 22.0 × 45.0 mm, which was found with an intact, regular, and thin membrane and a uniform echo without blood flow. The acoustic density of the sac fluid was transparent. Pelvic fluid collection with a depth of 10 mm existed as a liquid dark area around the uterus. A simple formula of Chinese herbs, Penyan Kang (formula for treating pelvic inflammation), was orally administered to the patient for 90 days. On the 6th return visit on May 10, 2008, the patient said that all the symptoms reported during the first visit had disappeared. The sonography taken on May 27, 2008 showed that the ovarian cyst on the right side had disappeared and that no abnormality was present. No side-effect of the treatment was reported.