Juergen Mack
Boehringer Ingelheim
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Publication
Featured researches published by Juergen Mack.
Bioorganic & Medicinal Chemistry Letters | 2011
Joerg Kley; Juergen Mack; Bradford S. Hamilton; Stefan Scheuerer; Norbert Redemann
Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in vivo validation of FAS as a therapeutic target. Optimisation yielded BI 99179 which is characterised by high potency, remarkably high selectivity and significant exposure (both peripheral and central) upon oral administration in rats.
Archive | 2000
Raymond A. Firestone; Wolfgang J. Rettig; Martin Lenter; Stefan Peters; Pilar Garin-Chesa; Juergen Mack; Dietmar Leipert; John Edward Park; Leila A. Telan
Archive | 2009
Roland Pfau; Kirsten Arndt; Henri Doods; Norbert Hauel; Klaus Klinder; Raimund Kuelzer; Juergen Mack; Henning Priepke; Dirk Stenkamp
Archive | 2005
Peter Nickolaus; Christopher Montague J. Meade; Domnic Martyres; Juergen Mack; Birgit Jung; Horst Dollinger; Georg Dahmann
Archive | 2005
Peter Nickolaus; Christopher Montague J. Meade; Domnic Martyres; Juergen Mack; Birgit Jung; Horst Dollinger; Georg Dahmann
Archive | 2005
Horst Dollinger; Juergen Mack; Domnic Martyres; Birgit Jung; Peter Nickolaus
Archive | 2005
Peter Nickolaus; Christopher John Montague Meade; Horst Dollinger; Juergen Mack; Georg Dahmann; Domnic Martyres; Birgit Jung
Archive | 2005
Thierry Bouyssou; Christoph Hoenke; Ingo Konetzki; Juergen Mack; Andreas Schnapp
Archive | 2006
Peter Sennhenn; Andreas Mantoulidis; Matthias Treu; Ulrike Tontsch-Grunt; Walter Spevak; Darryl Mcconnell; Andreas Schoop; Ralph Brueckner; Albrecht Jacobi; Ulrich Guertler; Gisela Schnapp; Christian Klein; Frank Himmelsbach; Alexander Pautsch; Bodo Betzemeier; Lars Herfurth; Juergen Mack; Dieter Wiedenmayer; Gerd Bader; Ulrich Reiser
Archive | 2005
Thierry Bouyssou; Ingo Konetzki; Philipp Lustenberger; Juergen Mack; Andreas Schnapp; Dieter Wiedenmayer; Christoph Hoenke; Klaus Rudolf
