Julia B. Mackenzie

Production of Pulmonary Edema by Thiourea in the Rat, and Its Relation to Age.

Conclusions Thiourea, in addition to effecting thyroid enlargement and a decline in the B.M.R., produces in appropriate doses, rapid and fatal pulmonary edema in adult rats. No necessary relation between these two reactions has been demonstrated. The immature rat is much less susceptible to the pulmonary edema and more susceptible to the thyroid enlargement produced by this compound. On a weight basis it tolerates 50 times the lethal dose for adult rats.

Occurrence of Tremors and Incoördination in Vitamin E-Deficient Adult Rats

Summary Rats grown and maintained on a highly purified vitamin E-deficient diet developed paralysis of the rear legs accompanied by tremors and incoödination of the fore legs and head. Although cures could not be obtained, the administration of a vitamin E concentrate arrested the development of these symptoms and stimulated growth.