Julia Jin

Abstract 138: Treating Infected Wounds in the Era of Antibiotic Resistance

PURPOSE: We recently described a bioinspired material composed of nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) that induces efficient osteogenic differentiation of human mesenchymal stem cells (hMSCs) without the addition of exogenous growth factors, thereby suggestive of a promising, growth factorfree, materials-based method for clinically utilizable bone regeneration. We have previously reported that MC-GAG scaffolds autogenously induce BMP receptor signaling via the canonical (Smad1/5) pathway. However, the necessary and sufficient components of this mechanism remain unknown. Our current study evaluates the contribution of the non-canonical (MAP kinase) pathway in MC-GAG induced osteogenesis.

Abstract 130: Better Living Through Chemistry

PURPOSE: The body responds to synthetic surfaces on implanted prosthetic devices with an inflammatory foreign body response (FBR), which results in the gradual deposition of a fibrous collagenous capsule. Capsular contracture (CC), the progressive growth and contraction of this peri-prosthetic capsule, is the most common complication of aesthetic and reconstructive breast surgery, affecting up to 47.5% of patients (1). CC causes breast pain, hardening, and deformity and is the most common indication for revision surgery. CC is thought to be due to an excessive FBR, however the etiology and pathophysiology of this process is poorly understood, and CC can occur in the absence of any putative risk factors. As such, there are no clinically approved therapies for prevention or treatment of CC. Rather, the complication is mitigated with re-operation and capsule excision, which often necessitates implant removal and replacement. Herein we altered the surface chemistry of silicone implants with Sigilon’s proprietary anti-inflammatory molecules, E9 and RZA15. These compounds are biocompatible small organic molecules which are covalently grafted to the surface of the implant. They are designed to reduce immune cell adhesion to the implant, leading to a truncated FBR and reduced fibrosis.

Abstract 15. Better Living through Chemistry: A Novel Breast Implant Surface Coating Significantly Reduces Peri-Prosthetic Capsule Formation

M oday, M arch 7, 2017 PURPOSE: Restoration of breast sensation following breast reconstruction is an evolving part of the reconstructive paradigm. Although spontaneous recovery of sensation has been reported following mastectomy, surgeons are advocating for innervated reconstructions using neurotization at the time of autologous reconstruction. In an effort to further elucidate the evidence basis for nerve coaptation, a meta-analysis of the literature was undertaken.