Julia Kruk-Jeromin

Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables

Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases.

Tattooing and Body Piercing - What Motivates You To Do It?

Background: Body ornamentation is becoming more and more popular, especially among young people. Aims: To establish the sociodemographic characteristics of people with tattoos or body piercing and to analyze the motivations for body ornamentation. Methods: The questionnaire studies were undertaken in Lodz — one of the largest cities in Poland. The data was collected from a group of 968 people, 476 of whom had a piercing and 492 a permanent tattoo. Results: Statistical analysis revealed that in the group of people with a tattoo, 36.8% were female and 63.2% were male. Contrary proportions were noted among people with a piercing: 78.8% female and 21.2% male. Conclusions: Body piercing is significantly more popular among women while tattooing is more popular in men. Among adolescents, body piercing is performed considerably earlier than tattooing. The main reasons for body ornamenting in the Polish population are the desire to enhance one’s individuality and the need to increase sexual attractiveness.

Individual and ethnic aspects of preoperative planning for posttraumatic rhinoplasty

The aim of this study was to compare the aesthetic results of post traumatic rhinoplasty among Europeans with populations of healthy Caucasians described in earlier reports, and to collate correct parameters of nasal shape in healthy representatives of both sexes and various races for improvement in aesthetic results of surgery. 3-D scanning of the face was performed in 54 patients after posttraumatic septorhinoplasty. Analysis of 3D model was based on two indices of the nasal proportions and four angles of the region from 18 anthropological points. Parameters of the nasal shape in addition to gender were compared to average values of healthy Caucasian population, described before. Normal characteristics of the nose among individuals of three races from previous studies were also compared to one another. In females, mean height and width of the nose as well as length of both nostrils was smaller. Neither were there any significant differences in width of the nostrils and length of the nasal pyramid nor nasal prominence. Nasal proportions were similar in both sexes. Some of the nasal angles differed in addition to gender. Posttraumatic rhinoplasty resulted in correct shape of the nose similar to the healthy Caucasian population. The aesthetic nose differ among healthy individuals of the three races analysed. While preoperative planning is important, knowledge of the normal values of parameters characterising shape in both genders is equally important as the individual differences in relation to the whole face.

Role of the internet in communication between patient and surgeon before rhinoplasty.

Abstract Our aim was to assess the use of the internet for patients considering rhinoplasty, to identify the influence of the medical information acquired, and to review favourable and adverse aspects of the acquired knowledge online. A prospective study was conducted on 106 patients listed for post-traumatic or aesthetic rhinoplasty. We surveyed 18 questions to evaluate demographic and sociological data, and the importance of the information acquired from the internet. Respondents searched online for description of operations, contact with other patients, and with the surgeon, and for preoperative and postoperative pictures. Patients who were considering aesthetic rhinoplasty were given medical information by a third party or from the internet, and those who were having post-traumatic corrections were usually referred by their general practitioner. We conclude that the internet is an important source of medical information about rhinoplasty for patients, but it does not contain enough data. It plays an essential part, particularly for those patients having the operation for aesthetic reasons, in contrast to those having post-traumatic correction. Reviewing and certifying the plastic surgical websites would validate certified services. Independent, direct contact with the doctor helps patients to obtain more accurate, personalised knowledge. In addition, surgeons should support patients by giving them a list of verified websites, which would contribute to increased doctor-patient communication.

Complications after body piercing in patient suffering from type 1 diabetes mellitus

Background  Body piercing has been a well‐known practice of body ornamentation. Nowadays, it is believed to involve from 6.5% to 50% of the population. Complications after body piercing procedures are variable.

The Internet as a Source of Information for Patients Prior to Rhinoplasty.

Objectives To determine the prevalence of Internet use by patients considering rhinoplasty and to identify the impact of such information on their decisions. Methods Prospective analysis of the impact of information received via the Internet by patients considering rhinoplasty on their decision-making prior to surgery. Eighty six patients, scheduled for post-traumatic or aesthetic rhinoplasty, received a questionnaire, consisting of 19 questions, which sought to evaluate their perception of the importance of the Internet information to them and also collected relevant demographic and sociological data. Results Respondents searched online for descriptions of medical procedures, information about how to contact other patients, pre- and post-operative pictures and making contact with a doctor. Patients considering aesthetic rhinoplasty received medical information from a third party or via the Internet. Individuals requiring post-traumatic surgical treatment were usually referred by family doctor. Conclusion Patients planning nasal aesthetic surgery form their opinions after consulting friends and searching the Internet, which can act as an important medical assistance.

Delayed two-stage breast reconstruction with implants: The authors' recent experience.

BACKGROUND Presently, breast cancer detection is delayed in Poland and, thus, the only other option for patients is amputation and breast reconstruction (immediate or delayed). Reconstructive methods are based on using the patients own tissue (pedicled or free myocutaneous flaps) or implants (a tissue expander, which is later exchanged for a prosthesis or an expandable implant). OBJECTIVE To evaluate the aesthetic results of a delayed two-stage breast reconstruction with the use of implants (expander and prosthesis) in patients who have previously undergone cancer-related mastectomy. METHODS From 2006 to 2009, 54 patients (34 to 65 years of age) underwent reconstruction at least one year after their mastectomy and adjuvant chemotherapy; three women also received x-ray therapy. All women underwent a two-stage treatment with a tissue expander, which was later exchanged for a prosthesis. RESULTS Outcomes of the surgery (evaluated by the physician and the patient at least six months after all stages of reconstruction) were found to be very good in 42 patients and good in 12 patients. After amputation and x-ray therapy in two cases, a fistula developed, which necessitated implant removal. CONCLUSIONS After amputation, breast reconstruction with implants (expander and prosthesis) provides good aesthetic results. The method is mildly burdening to the patient and does not cause severe scarring. Symmetrization of the second breast is often recommended; however, the cost is not covered by the national health system. In principle, earlier x-ray therapy disqualifies the application of implants. Dividing reconstruction into two stages (expander and prosthesis) allows for possible correction of prosthesis placement.