Julie Thomson

Elemental fluorine Part 12. Fluorination of 1,4-disubstituted aromatic compounds☆

Abstract Direct fluorination of a series of 1,4-disubstituted benzene derivatives in acid reaction media at convenient temperature leads, in many cases, to selectively fluorinated aromatic products in preparatively useful conversions and yields.

Elemental fluorine. Part 3 [1]. The preparation of dialkyl fluoromalonates by direct fluorination

Abstract Dialkyl fluoromalonates have been prepared by treating the sodium derivatives of the parent dialkyl malonates with elemental fluorine.

Electrophilic fluorination using elemental fluorine

Electrophilic fluorination by elemental fluorine is promoted by the use of protonic acids; formic and sulfuric acids are especially effective.

Elemental fluorine. Part 1. Synthesis of fluoroaromatic compounds

Direct fluorination of 4-fluorobenzoic acid, as a model substrate in a variety of reaction media, shows that 98% formic acid and concentrated sulfuric acid are excellent for promoting electrophilic fluorination. A high degree of fluorination may be achieved using concentrated sulfuric acid, showing that in this medium fluorine will act as a powerful electrophile.