Julien Lambert

Airborne and systemic dermatitis, mimicking atopic dermatitis, caused by methylisothiazolinone in a young child.

A case study is presented of a 4-year old child with papular dermatitis caused by methylisothiazolinone in wipes and paint.

Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors.

Background:  Peroxisome proliferator‐activated receptors (PPARs) mediate several functions that are of interest in carcinogenesis. Although PPARα, PPARβ, and PPARγ are expressed in multiple human, their expression has not been investigated in non‐melanoma skin cancer.

Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis

In experimentally‐induced irritant (ICD) and allergic (ACD) contact dermatitis, an oil‐in‐water (o/w) cream was applied to investigate its effects on a disturbed barrier function compared to untreated physiological barrier repair. Transepidermal water loss (TEWL) measurements were performed. Before the start of the experiments, the skin tolerance of the cream was examined, revealing the non‐irritating characteristics of the ingredients and the absence of any contact allergic patch test reaction. In the ICD study, sodium lauryl sulfate (SLS) patches were applied to the forearms of young female volunteers. Consequently, it was observed that repeated cream application (14 days, 2×/day) significantly improved the TEWL of SLS‐damaged skin, leading to a complete recovery on day 15. In the ACD study, disruption of skin barrier function was obtained by a nickel‐mediated contact allergy patch (CAP) test. The cream was then applied 2×/day for 4 consecutive days. Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair.

Lansoprazole-induced subacute cutaneous lupus erythematosus: two cases.

Sir, Subacute cutaneous lupus erythematosus (SCLE) is a well defined subtype of LE, characterized by annular and/or psoriasiform lesions, limited systemic involvement and presence of circulating SSA/anti-Ro antibodies (1). In contrast to drug-induced systemic LE, the association between drugs and SCLE is not well documented (2). Several cases of SCLE have been reported to occur with thiazides, ACE inhibitors, calcium channel blockers, statins, antimycotics, phenytoin and non-steroidal anti-inflammatory drugs (2–5). Lansoprazole is a potent proton pump inhibitor which is widely used in the treatment of gastroduodenal ulcers (6, 7). Although the incidence of lansoprazole-induced cutaneous drug reactions is low (v2%), maculopapular rashes, urticaria and pruritus have been reported (6, 7). Incidental reports suggest the association between use of proton pump inhibitors and other cutaneous drug reactions (8, 9). To our knowledge, we here report the first cases of lansoprazole-induced SCLE.

Acne is prevalent but use of its treatments is infrequent among adolescents from the general population

Background  Little is known about the use of acne treatments among teenagers in the community.

Chronic pruritic neutrophilic eccrine hidradenitis in a patient with Behçet's disease.

Summary Neutrophilic eccrine hidradenitis (NEH) is a rare distinct entity that usually presents as asymptomatic erythematous papules that disappear spontaneously in 1–3 weeks. However, its appearance may be polymorphic, pruritic, recurrent or even chronic as is described in this case. The histological combination of neutrophilic infiltration in and necrosis of the eccrine secretory gland epithelium is highly characteristic for NEH. It typically occurs in patients receiving chemotherapeutic drugs for malignancies, but other associations have also been reported. To our knowledge, we report the first case of NEH in a patient with Behçets disease (BD). Cutaneous manifestations of BD, an inflammatory systemic disorder of unknown origin, include neutrophilic dermatoses such as Sweets syndrome and pyoderma gangrenosum, although these are unusual in BD. NEH could be another neutrophilic dermatosis related to BD. This observation suggests that NEH is not strictly related to chemotherapeutic drugs and malignancies. It appears to be a reactive dermatosis associated with other factors as well, including BD. Treatment was successful with dapsone 100 mg daily.

Cigarette smoking and acne in adolescents: results from a cross-sectional study.

Background  Previous studies on the association between smoking and acne have reported conflicting results.

Occupational allergic contact dermatitis from bisphenol A in vinyl gloves

Allergic contact dermatitis caused by polyvinyl chloride gloves is rarely reported, and in only 2 cases was bisphenol A considered to be the responsible sensitizer. We report a patient with occupational hand dermatitis after the use of a new type of high‐density vinyl (HDV) gloves. Patch tests showed positive (++) reactions to both used and new HDV gloves and to bisphenol A. Chemical analysis by gas chromatography‐mass spectrometry demonstrated the presence of bisphenol A in the HDV gloves. Replacement by nitrile rubber gloves resulted in complete clearance of the hand dermatitis.

Polyhexamethylene biguanide is a relevant sensitizer in wet wipes

Polyhexamethylene biguanide (PHMB; CAS no. 2875743-3) is a preservative used as a biocide in industrial products (e.g. swimming pool disinfectants), medical devices (e.g. wound cleansers), contact lens solutions, and cosmetics such as wet wipes, deodorants, and facial cleansers. It is considered to be a rare contact allergen, with a sensitization rate of ∼ 0.5% in an unselected population (1, 2). Moreover, sensitization does not seem to be associated with cosmetic exposure (2). Here, we report a case of allergic contact dermatitis following the use of wet wipes containing PHMB.

Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire?

Methylisothiazolinone (MI) contact allergy is severely affecting consumers with allergic contact dermatitis, owing to its presence in cosmetics, household detergents, and water‐based paints, in particular. Data on the true isothiazolinone concentrations in these products are scarce, and labelling may be incorrect.