Júlio Carlos Noronha

GSTM1 polymorphism and oral squamous cell carcinoma

We investigated the frequency of the GSTM1 genotypes in 70 Brazilian patients with oral squamous cell carcinoma (OSCC) and 82 age-sex matched controls. The GSTM1 genotypes were studied by PCR-based methods. The frequency of male patients with OSCC and null for the GSTM1 (70.5%) was statistically different from the male patients from the control group (48.5%) (Odds Ratio, OR=2.53, 95% CI=1.22-5.24, P<0.05). The frequency of the GSTM1 null genotype (0/0) in the group with OSCC (65.7%) was statistically different from the controls (48.7%) (OR=2.01, 95% CI=1.04-3.88, P<0.05). The prevalence of GSTM1 deficiency (null) was significantly higher for patients with oral cancer of the floor of the mouth (OR=3.67, 95% CI=1.11-12.11, P<0.05). In conclusion, the GSTM1 null genotype may increase the risk for OSCC development.

Analysis of T102C 5HT2A Polymorphism in Brazilian Psychiatric Inpatients: Relationship with Suicidal Behavior

Abstract1. Central serotonergic dysfunction and genetic factors are associated with suicidal behavior in psychiatric patients. The goal of this study was to examine the association between the 5-HT2A gene polymorphism (102T/C) and suicide in a sample of Brazilian psychiatric inpatients.2. We studied 225 subjects. Genotypic frequencies were obtained after DNA extraction and the region of 5-HT2A/T102C containing the polymorphic site amplified by the polymerase chain reaction and digested with the restriction enzyme HpaII.3. No differences were found between patients with and without suicide attempt history. Patients with a history of severe suicide attempts also did not exhibit different genotypic frequencies when compared with patients without a suicide attempt history.4. These results suggest that the 5HT2A gene polymorphism (102T/C) may not be involved in the genetic susceptibility to suicidal behavior.

A Eficácia do Hidróxido de Cálcio no Tratamento Endodôntico de Decíduos: Seis Anos de Avaliação

Resumen pt: Objetivo: avaliar os resultados clinicos e radiograficos da utilizacao do hidroxido de calcio no tratamento endodontico em deciduos (com necrose pulpar, ...