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Dive into the research topics where Jun Kawasaki is active.

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Featured researches published by Jun Kawasaki.


Anesthesia & Analgesia | 2004

Electron microscopic evaluations of clot morphology during thrombelastography

Jun Kawasaki; Nobuyuki Katori; Mitsuharu Kodaka; Hideki Miyao; Kenichi A. Tanaka

In this study, we characterized clot morphology with a scanning electron microscope (SEM) at time points corresponding to the commonly used thrombelastography (TEG®) variables, illustrating the correlation of the physical clot formation with TEG® tracings. The first channel of the TEG® analyzer was used to obtain the tracings of clot formation, while the sub-samples for the SEM were obtained from the second TEG® channel. Different types of samples were examined, including whole blood, abciximab-treated whole blood, platelet-rich plasma (PRP), and abciximab-treated PRP. The SEM images were obtained at reaction time, different amplitudes (5–30 mm), maximum amplitude (MA), and at amplitude 60 min after MA. In the whole blood, coarse fibrin and activated platelets were observed at reaction time and fibrin strands progressively became more solid and intertwined at amplitude 10 mm and thereafter. Red blood cells were surrounded with fibrin strands at amplitude 30 mm and were tightly packed by fibrin strands at MA. In abciximab-treated whole blood, red blood cell shape was maintained at MA. The process of fibrin formation and platelet activation was also examined in PRP. Abciximab did not block platelet shape change, although the blockage of fibrin binding to platelets was shown on the TEG® analyzer. In summary, we have shown structural changes of the forming clot in relation to TEG® variables.


Journal of Anesthesia | 2002

Blood component therapy guided by celite-activated thromboelastography for perioperative coagulopathy

Jun Kawasaki; Kenichi A. Tanaka; Nobukazu Sato; Toshie Saitoh; Masahiro Shimizu; Taro Kawazoe

Case 1 was a 54-year-old man (weight, 65kg; height, 160cm), who while a bicycling was involved in a head-on collision with a truck. He was brought to the emergency room with findings of a slightly depressed level of consciousness (Glasgow Coma Scale [GCS]II score of 4). His abdomen was distended, and computed tomography (CT) scanning revealed a highresolution lesion that was widespread throughout the mesentery, consistent with intraabdominal bleeding. He was orally intubated, and 1800ml of packed red blood cells (RBC) was administered in the emergency room. Subsequently, he was brought to the operating room for exploratory laparotomy. General anesthesia was maintained with O2 and sevoflurane. We were not able to detect any clot formation on celite-activated TEG immediately after induction of anesthesia (Fig. 1A). The patient showed continuous bleeding, which required crystalloid 5700ml; RBC 3600 ml; and fresh frozen plasma (FFP), 1200ml. Tranexamic acid 1500mg was given because increased fibrinolysis was also suspected from the minimal clot formation. Blood loss was estimated as 12000 ml by the time surgical hemostasis was established. Subsequent TEG showed near-normal reaction (R) time (8.3min), but severely decreased α angle and maximum amplitude (MA; 23° and 19mm), suggesting decreased platelet count (Fig. 1B). It also showed hyperfibrinolysis (Lysis index at 60min [LY60], 17.5%). Platelet count was measured together with the second TEG, and it was 23000/mm3, consistent with a reduced α angle and MA. Thirty-five units of platelets, FFP 560ml, and tranexamic acid 1000mg were given. At the end of the surgery, TEG showed near-normal values (Fig. 1C; R, 2.5min; α, 54°; MA, 47mm; and LY60, 5.5%). There was no increased bleeding from the drainage tube after the operation. Address correspondence to: J. Kawasaki Received: March 14, 2001 / Accepted: August 9, 2001


Archive | 1995

A Method for Studying Interaction Between Non-Deporalizing Neuromuscular Blockers and Other Drugs in Vivo

Mitsuharu Kodaka; Hideki Miyao; Jun Kawasaki; Akinori Katayama; Hiroyuki Sekiguchi; Ichiro Ishizuka; Taro Kawazoe

In view of clinical set, there are not so many methods for studying interactions between non-deporalizing neuromuscular blockers and other drugs. We schemed out a new methods for studying the interactions mentioned above.


BJA: British Journal of Anaesthesia | 2004

Relation between fentanyl dose and predicted EC50 of propofol for laryngeal mask insertion.

Mitsuharu Kodaka; Yumi Okamoto; F Handa; Jun Kawasaki; Hideki Miyao


Archive | 2005

Method for testing efficacy of antithrombotic agent

Jun Kawasaki; Kenichi A. Tanaka


Anesthesiology Abstracts of Scientific Papers Annual Meeting ( ) | 2003

Effects of Platelet Agonists on Thromboelastogram in the Presence of Heparin or Argatroban

Jun Kawasaki; Kenichi A. Tanaka; Kiyoshi Okada; Hideki Miyao


The Journal of Japan Society for Clinical Anesthesia | 2011

A Case of Impaired Platelet Function after 15-day Cessation of Ticlopidine and Aspirin : A Case Report

Jun Kawasaki; Chika Kojima; Sayaka Hara; Kaoru Koyama; Hideki Miyao; Kenichi A. Tanaka


Japanese Journal of Thrombosis and Hemostasis | 2010

Management of Perioperative Hemostasis using Thromboelastometry

Satoru Ogawa; Jun Kawasaki; Kenichi A. Tanaka


Anesthesiology | 2002

The Effect of Magnesium on Coagulation in Parturients with Preterm Labor: [2002][A-1065]

Katsuo Terui; Jun Kawasaki; Kazumi Yokota; Chieko Kawamura; Hideki Miyao


Anesthesiology | 2002

Do Platelet Activators (Epinephrine, ADP and Collagen) Affect Whole Blood Clot Formation on Thromboelastogram?: [2002][A-534]

Jun Kawasaki; Kenichi A. Tanaka; Tohru Wada; Katsuo Terui; Hideki Miyao

Collaboration


Dive into the Jun Kawasaki's collaboration.

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Hideki Miyao

Saitama Medical University

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Mitsuharu Kodaka

Saitama Medical University

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Taro Kawazoe

Saitama Medical University

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Akinori Katayama

Saitama Medical University

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Ichiro Ishizuka

Saitama Medical University

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Kaoru Koyama

Saitama Medical University

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Yumi Okamoto

Saitama Medical University

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F Handa

Saitama Medical University

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