Junetsu Ito

On the transcription of the tryptophan operon in Escherichia coli: I. The tryptophan operator

Mutations in the anthranilate synthetase eistron can alter the capacity to synthesize other enzymes of the tryptophan pathway in Escherichia coli. On the other hand, a deletion over the anthranilate synthetase eistron leads to non-repressible transcription of tryptophan genes. From this evidence it is concluded that the operator should be localized at the anthranilate synthetase eistron extremity of the operon.