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Featured researches published by Jung-Sick Lee.


Science of The Total Environment | 2014

Perfluorinated alkyl substances in water, sediment, plankton and fish from Korean rivers and lakes: A nationwide survey

Nguyen-Hoang Lam; Chon-Rae Cho; Jung-Sick Lee; Ho-Young Soh; Byoungcheun Lee; Jae-An Lee; Norihisa Tatarozako; Kazuaki Sasaki; Norimitsu Saito; Katsumi Iwabuchi; Kurunthachalam Kannan; Hyeon-Seo Cho

Water, sediment, plankton, and blood and liver tissues of crucian carp (Carassius auratus) and mandarin fish (Siniperca scherzeri) were collected from six major rivers and lakes in South Korea (including Namhan River, Bukhan River, Nakdong River, Nam River, Yeongsan River and Sangsa Lake) and analyzed for perfluorinated alkyl substances (PFASs). Perfluorooctane sulfonate (PFOS) was consistently detected at the greatest concentrations in all media surveyed with the maximum concentration in water of 15 ng L(-1) and in biota of 234 ng mL(-1) (fish blood). A general ascending order of PFAS concentration of water<sediment<plankton<crucian carp tissues<mandarin fish tissues was found. Except for the Nakdong River and Yeongsan River, the sum PFAS concentrations in water samples were below 10 ng L(-1). The PFOS and perfluorooctanoic acid (PFOA) concentrations in water did not exceed levels for acute and/or chronic effects in aquatic organisms. High concentrations of long chain perfluorocarboxylates (LCPFCAs) were found in sediment samples. PFOS, perfluoroundecanoic acid (PFUnA), perfluorododecanoic acid (PFDoA) and perfluorodecanoic acid (PFDA) accounted for 94-99% of the total PFASs concentration in fish tissues. The mean ratios of PFAS concentration between fish blood and fish liver were above 2 suggesting higher levels in blood than in liver. Significant positive correlations (r>0.80, p<0.001) were observed between PFOS concentration in blood and liver tissues of both crucian carp and mandarin fish. This result suggests that blood can be used for nonlethal monitoring of PFOS in fish. Overall, the rank order of mean bioconcentration factors (BCFs) of PFOS in biota was; phytoplankton (196 L/kg)<zooplankton (3,233 L/kg)<crucian carp liver (4,567 L/kg)<crucian carp blood (11,167 L/kg)<mandarin liver (24,718 L/kg)<mandarin blood (73,612 L/kg).


BJA: British Journal of Anaesthesia | 2011

Dose-related attenuation of cardiovascular responses to tracheal intubation by intravenous remifentanil bolus in severe pre-eclamptic patients undergoing Caesarean delivery

Byoung Yun Park; Cheol Won Jeong; E.A. Jang; Seok-Jai Kim; Sung Tae Jeong; Malshick Shin; Jung-Sick Lee; Kyung Yeon Yoo

BACKGROUND The optimal dose of remifentanil to attenuate the cardiovascular responses to tracheal intubation in pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia has not been established. We compared the effects of two low doses of remifentanil on the cardiovascular responses to tracheal intubation and neonatal outcomes. METHODS Forty-eight women with severe pre-eclampsia were randomly assigned to receive either remifentanil 0.5 µg kg⁻¹ (R0.5 group, n=24) or 1 µg kg⁻¹ (R1.0 group, n=24) over 30 s before induction of anaesthesia using thiopental 5 mg kg⁻¹ and succinylcholine 1.5 mg kg⁻¹. Systolic arterial pressure (SAP), heart rate (HR), and plasma catecholamine concentrations were measured. Neonatal effects were assessed using Apgar scores and umbilical cord blood gas analysis. RESULTS SAP was decreased by induction of anaesthesia and increased by tracheal intubation in both groups. The peak SAP after intubation was greater in the R0.5 group than in the R1.0 group, whereas it did not exceed baseline values in either group. HR increased significantly above baseline in both groups with no significant differences between the groups. Three subjects in the R1.0 group received ephedrine due to hypotension (SAP < 90 mm Hg). Norepinephrine concentrations remained unaltered after intubation and increased significantly at delivery with no significant differences between the groups. Neonatal Apgar scores and umbilical arterial and venous pH and blood gas values were comparable between the groups. CONCLUSIONS Both doses of remifentanil effectively attenuated haemodynamic responses to tracheal intubation with transient neonatal respiratory depression in pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia. The 1.0 µg kg⁻¹ dose was associated with hypotension in three of 24 subjects.


International Journal of Obstetric Anesthesia | 2013

A dose–response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia

Kyung Yeon Yoo; D.H. Kang; Hyejin Jeong; Cheol Won Jeong; Y.Y. Choi; Jung-Sick Lee

BACKGROUND Remifentanil is known to attenuate the cardiovascular responses to tracheal intubation. We determined effective doses (ED(50)/ED(95)) of remifentanil to prevent the pressor response to tracheal intubation in patients with severe preeclampsia. METHODS Seventy-five women with severe preeclampsia were randomly allocated to one of five remifentanil dose groups (0.25, 0.50, 0.75, 1.0, or 1.25 μg/kg) given before induction of anaesthesia using thiopental 5 mg/kg and suxamethonium 1.5 mg/kg. Systolic arterial pressure, heart rate and plasma catecholamine concentrations were measured. Neonatal effects were assessed by Apgar scores and umbilical cord blood gas analysis. A dose was considered effective when systolic arterial pressure did not exceed 160 mmHg for more than 1 min following tracheal intubation. RESULTS Baseline systolic blood pressure and heart rate did not differ among the groups. The intubation-induced increases of heart rate and blood pressure were attenuated in a dose-dependent manner by remifentanil. ED(50) and ED(95) were 0.59 (95% CI 0.47-0.70) μg/kg and 1.34 (1.04-2.19)μg/kg, respectively. Norepinephrine concentrations remained unaltered following intubation but increased significantly at delivery, with no differences between the groups. Apgar scores and umbilical arterial and venous pH and blood gas values were comparable among the groups. Two women each in the 1.0 and 1.25 μg/kg groups received ephedrine for hypotension defined as systolic arterial pressure <90 mmHg. CONCLUSIONS The ED(95) of remifentanil for attenuating the hypertensive response to tracheal intubation during induction of anaesthesia in severely preeclamptic patients undergoing caesarean delivery under general anaesthesia was 1.34 μg/kg.


Acta Anaesthesiologica Scandinavica | 2012

Haemodynamics and cerebral oxygenation during arthroscopic shoulder surgery in beach chair position under general anaesthesia.

Hyejin Jeong; Seung-Han Lee; Eun a Jang; Sung-Su Chung; Jung-Sick Lee; Kyung Yeon Yoo

Patients undergoing surgery in beach chair position (BCP) are at risk of cerebral ischaemia. We determined the prevalence and risk factors of jugular venous bulb oxygen desaturation (SjvO2 < 50%) in BCP. It was also examined whether regional cerebral tissue oxygen saturation (SctO2) measured by near‐infrared spectroscopy and SjvO2 are interchangeable for assessment of cerebral oxygenation.


BJA: British Journal of Anaesthesia | 2010

Altered cardiovascular responses to tracheal intubation in patients with complete spinal cord injury: relation to time course and affected level

Kyung Yeon Yoo; Cheol Won Jeong; Seok-Jai Kim; Sung Tae Jeong; Sang-Hyun Kwak; Malshick Shin; Jung-Sick Lee

BACKGROUND We determined cardiovascular responses to tracheal intubation in relation to the time since injury in patients with different levels of spinal cord injury. METHODS Two hundred and fourteen patients with complete cord injury were studied. They were either quadriplegics (>C7, n=71) or paraplegics (20 yr. Twenty patients with no cord injury served as controls. Systolic arterial pressure (SAP), heart rate (HR), and plasma catecholamine concentrations were determined. RESULTS Intubation did not affect SAP in the quadriplegics regardless of the time post-injury, but it significantly increased SAP in all paraplegics. Moreover, the pressor response was enhanced in the paraplegics who were 10 yr or more since injury (P<0.05). HR increased significantly in all groups; the magnitude of the increase was less only in acute quadriplegics compared with controls. Plasma concentrations of norepinephrine increased in every group except for the quadriplegics within 4 weeks of injury. The maximum increases in SAP, HR, and norepinephrine from awake baseline values were smaller in the quadriplegics than in the paraplegics (P<0.01). CONCLUSIONS The cardiovascular and catecholamine responses to intubation change as a function of the time elapsed and the level of the cord injury. In this study, the pressor response to tracheal intubation was abolished in the quadriplegics but not in paraplegics; indeed, it was enhanced at 10 yr or more since injury in this group.


Acta Anaesthesiologica Scandinavica | 2009

Anaesthetic requirement and stress hormone responses in patients undergoing lumbar spine surgery: anterior vs. posterior approach.

Kyung Yeon Yoo; M. K. Lee; Cheol Won Jeong; Seok-Jai Kim; Seongwook Jeong; Malshick Shin; JongUn Lee; Jung-Sick Lee

Background: The intensity of nociceptive stimuli reflects the severity of tissue injury. The anaesthetic requirement and stress hormonal responses were determined to learn whether they differ according to different surgical approaches (anterior vs. posterior) during the spinal surgery.


Fisheries and Aquatic Sciences | 2012

Effect of Inorganic Mercury on Hematological and Antioxidant Parameters on Olive Flounder Paralichthys olivaceus

Jun-Hwan Kim; Jung-Sick Lee; Ju-Chan Kang

The effects of inorganic mercury on hematological parameters and hepatic oxidative stress enzyme activity were studied in olive flounder Paralichthys olivaceus. Fish were injected twice intraperitoneally with mercuric chloride (2, 4, or 8 mg Hg/kg BW). The major hematological findings were significant decreases in the red blood cell count, hematocrit value, and hemoglobin level in olive flounder exposed to 8 mg Hg/kg BW. Remarkably low levels of calcium and chloride, and reduced osmolality, were also observed at 8 mg Hg/kg BW. In hepatic tissue, significant increases in glutathione peroxidase and catalase activity were observed above 4 mg Hg/kg BW Inorganic mercury also increased glutathione S-transferase and glutathione reductase activity at 8 mg Hg/ kg BW in hepatic tissue. The present findings suggest that exposure to a low concentration (≥4 mg Hg/kg BW) of inorganic mercury can cause significant changes in hematological and antioxidant parameters.


Environmental Toxicology and Pharmacology | 2017

Toxic effects of juvenile sablefish, Anoplopoma fimbria by ammonia exposure at different water temperature

Jun-Hwan Kim; Hee-Ju Park; In-Ki Hwang; Jae-Min Han; Do-Hyung Kim; Chul Woong Oh; Jung-Sick Lee; Ju-Chan Kang

Juvenile sablefish, Anoplopoma fimbria (mean length 17.1±2.4cm, and mean weight 75.6±5.7g) were used to evaluate toxic effects on antioxidant systems, immune responses, and stress indicators by ammonia exposure (0, 0.25, 0.75, and 1.25mg/L) at different water temperature (12 and 17°C) in 1 and 2 months. In antioxidant responses, superoxide dismutase (SOD) and catalase (CAT) were significantly increased by ammonia exposure, whereas glutathione (GSH) was decreased. In immune responses, lysozyme and phagocytosis activity were significantly increased by ammonia exposure. In stress indicators, plasma glucose, heat shock protein 70 (HSP 70), and cortisol were significantly increased. At high water temperature (17°C), alterations by ammonia exposure were more distinctly. The results of this study indicated that ammonia exposure can induce toxic effects in the sablefish, and high water temperature can affect the ammonia exposure toxicity.


Acta Anaesthesiologica Scandinavica | 2012

Thiopental dose requirements for induction of anaesthesia and subsequent endotracheal intubation in patients with complete spinal cord injuries

Kyung Yeon Yoo; Cheol Won Jeong; Hyejin Jeong; Seung-Han Lee; J. H. Na; Seok-Jai Kim; Sung Tae Jeong; Jung-Sick Lee

Dose requirements of thiopental depend on patient characteristics and infusion rate. We determined thiopental dose requirements for induction of anaesthesia, and the effects of remifentanil on cardiovascular and bispectral index (BIS) responses to tracheal intubation in spinal cord‐injured (SCI) patients undergoing general anaesthesia.


BJA: British Journal of Anaesthesia | 1999

Intracoronary propofol attenuates myocardial but not coronary endothelial dysfunction after brief ischaemia and reperfusion in dogs

Kyung Yeon Yoo; S Y Yang; Jung-Sick Lee; Woong Mo Im; Chang-Young Jeong; Sung-Su Chung; Sang-Hyun Kwak

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Kyung Yeon Yoo

Chonnam National University

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Cheol Won Jeong

Chonnam National University

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Ju-Chan Kang

Pukyong National University

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Seok-Jai Kim

Chonnam National University

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Hyejin Jeong

Chonnam National University

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Malshick Shin

Chonnam National University

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Sung Tae Jeong

Chonnam National University

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Sang-Hyun Kwak

Chonnam National University

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Seung-Han Lee

Chonnam National University

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Sung-Su Chung

Chonnam National University

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