Jungwook Chin
Seoul National University
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Publication
Featured researches published by Jungwook Chin.
Chemical Communications | 2013
Aeju Lee; Jungwook Chin; Ok Kyu Park; Hyunjin Chung; Jin Won Kim; Soo Young Yoon; Kyeongsoon Park
A novel near-infrared fluorescence (NIRF) copper sensor allows rapid and ultra-sensitive detection of copper ions with excellent selectivity and specificity due to the specificity of click ligation and effective dark-quenching mechanism.
Organic Letters | 2013
Hiyoung Kim; Jungwook Chin; Hyukjae Choi; Kyungryul Baek; Seong Eon Park; Weihong Wang; Dongyup Hahn; Inho Yang; Jihye Lee; Bora Mun; Merrick Ekins; Sang-Jip Nam; Heonjoong Kang
Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC(50) of 23.7 nM.
Drug Discovery Today: Technologies | 2012
Jungwook Chin; K.A. Foyez Mahmud; Sung Eun Kim; Kyeongsoon Park; Youngro Byun
Although significant progress has been made in developing oral formulations to deliver bioactive proteins and peptide therapeutics, oral routes still need to overcome formidable barriers such as poor stability and permeability and rapid enzymatic degradation. Thus, novel formulation technologies for oral delivery of proteins and peptides are needed to further improve the bioavailability and therapeutic efficacy. In recent decades, researchers have attempted different strategies to successfully deliver proteins orally. In this review, we examine the current technologies being developed for protein and peptide oral delivery.
Steroids | 2012
Kyoungjin Shin; Jungwook Chin; Dongyup Hahn; Jaehwan Lee; Hoosang Hwang; Dong Hwan Won; Jungyeob Ham; Hyukjae Choi; Eunsoo Kang; Hiyoung Kim; Moon Kyeong Ju; Sang-Jip Nam; Heonjoong Kang
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC(50)s 14 and 15μM.
Journal of Natural Products | 2013
Weihong Wang; Bora Mun; Yehee Lee; Mallepally Venkat Reddy; Youngmin Park; Jihye Lee; Hiyoung Kim; Dongyup Hahn; Jungwook Chin; Merrick Ekins; Sang-Jip Nam; Heonjoong Kang
Chemical investigation of a Korean marine sponge, Monanchora sp., yielded nine new sesterterpenoids (1-9) along with phorbaketals A-C (10-12). The planar structures were established on the basis of NMR and MS analysis, and the absolute configurations of 1-9 were defined using the modified Moshers method and CD spectroscopic data analysis. Compounds 1-8, designated as phorbaketals D-K, possess a spiroketal-modified benzopyran moiety such as phorbaketal A, and their structural variations are due to oxidation and/or reduction of the tricyclic core or the side chain. Compound 9, designated as phorbin A, has a monocyclic structure and is proposed to be a possible biogenetic precursor of the phorbaketals. Compounds 1-9 were evaluated for cytotoxicity against four human cancer cell lines (A498, ACHN, MIA-paca, and PANC-1), and a few of them were found to exhibit cytotoxic activity.
Journal of Natural Products | 2015
Hiyoung Kim; Inho Yang; Shin-Young Ryu; Dong Hwan Won; Awadut G. Giri; Weihong Wang; Hyukjae Choi; Jungwook Chin; Dongyup Hahn; Eunhee Kim; Chulkyeong Han; Jihye Lee; Sang-Jip Nam; Won-Kyung Ho; Heonjoong Kang
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.
Organic Letters | 2009
Hong Ryul Ahn; Young Ae Cho; Dong-Su Kim; Jungwook Chin; Young-Soo Gyoung; Seokjoon Lee; Heonjoong Kang; Jungyeob Ham
Potassium organoselanyltrifluoroborates have been prepared from the corresponding dihalobenzene compounds in 56-92% yields through a facile one-pot, multicomponent reaction. The microwave-promoted Suzuki-Miyaura cross-coupling reaction of these substrates with various aryl and alkenyl bromides in the presence of 3.0 mol % of Pd(PPh(3))(4) and 3.0 equiv of K(2)CO(3) in aqueous 1,4-dioxane at 130 degrees C provided the desired compounds in 54-91% yields.
Bioorganic & Medicinal Chemistry Letters | 2013
Dongyup Hahn; Dong Hwan Won; Bora Mun; Hiyoung Kim; Chulkyeong Han; Weihong Wang; Taeho Chun; Sunhee Park; Dajeong Yoon; Hyukjae Choi; Sang-Jip Nam; Merrick Ekins; Jungwook Chin; Heonjoong Kang
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.
Bioorganic & Medicinal Chemistry Letters | 2010
Jaeyoung Ko; Hoosang Hwang; Jungwook Chin; Dongyup Hahn; Jaehwan Lee; Inho Yang; Kyoungjin Shin; Jungyeob Ham; Heonjoong Kang
A novel class of natural PPAR agonists, 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone (1), were discovered in marine natural product libraries. The synthesis of 1 was accomplished starting from vinylmethyl ketone. Ring formation of the α,γ dialkyl γ-lactone was achieved via the stereo-controlled reaction of a ketyl radical anion with a chiral methacrylate. In the PPAR agonistic assay, the most potent of the four stereoisomers had EC(50) values of 12 μM for mPPARα, 9 μM for mPPARδ and >100 μM for mPPARγ.
Journal of Natural Products | 2016
Dongyup Hahn; Hiyoung Kim; Inho Yang; Jungwook Chin; Hoosang Hwang; Dong Hwan Won; Byoungchan Lee; Sang-Jip Nam; Merrick Ekins; Hyukjae Choi; Heonjoong Kang
Three new structurally related depsipeptides, halicylindramides F-H (1-3), and two known halicylindramides were isolated from a Petrosia sp. marine sponge collected off the shore of Youngdeok-Gun, East Sea, Republic of Korea. Their planar structures were elucidated by extensive spectroscopic data analyses including 1D and 2D NMR data as well as MS data. The absolute configurations of halicylindramides F-H (1-3) were determined by Marfeys method in combination with Edman degradation. The absolute configurations at C-4 of the dioxyindolyl alanine (Dioia) residues of halicylindramides G (2) and H (3) were determined as 4S and 4R, respectively, based on ECD spectroscopy. The C-2 configurations of Dioia in 2 and 3 were speculated to both be 2R based on the shared biogenesis of the halicylindramides. Halicylindramides F (1), A (4), and C (5) showed human farnesoid X receptor (hFXR) antagonistic activities, but did not bind directly to hFXR.