Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Juni Ekowati is active.

Publication


Featured researches published by Juni Ekowati.


Journal of Ethnopharmacology | 2018

Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition

Idha Kusumawati; Kresma Oky Kurniawan; Subhan Rullyansyah; Tri Anggono Prijo; Retno Widyowati; Juni Ekowati; Eka Pramyrtha Hestianah; Suprapto Maat; Katsuyoshi Matsunami

ETHNOPHARMACOLOGICAL RELEVANCE Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use. MATERIALS AND METHODS The antioxidant activity was determined using the DPPH free radical method, and anti-aging activity was examined using in vitro assays such as tyrosinase inhibitor and collagenase inhibitor. In vivo tests were performed by observing histomorphologic changes in rat skin exposed to Ultraviolet (UV) rays. The total curcuminoid contents and chromatographic profiles were determined by Thin Layer Chromatography (TLC) - densitometry. RESULTS In all in vitro assays, all of the extracts showed a dose-dependent manner in the final concentration range from 62.5 to 500 µg/mL for DPPH assay and 31.25 to 250 µg/mL for tyrosinase inhibition and collagenase inhibition assay. Curcuminoid (CUR), the active principle of Curcuma genus shows antioxidant, tyrosinase inhibitor and collagenase inhibitor activity greater than all C. heyneana extracts. The in vivo assay results showed that the topical application of the crude extract of C. heyneana produced significant improvement effects on the UV-induced skin structure damage. The total CUR content was correlated with the anti-aging activity of Curcuma heyneana. CONCLUSIONS The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical.


Archive | 2014

SYNTHESIS AND BRINE SHRIMP LETHALITY TEST OF SOME BENZOXAZINE AND AMINOMETHYL DERIVATIVES OF EUGENOL

Marcellino Rudyanto; Juni Ekowati; Tri Widiandani; Toshio Honda; Jalan Dharmawangsa Dalam


Universa Medicina | 2016

Ethyl p-methoxycinnamate from Kaempferia galanga inhibits angiogenesis through tyrosine kinase

Juni Ekowati; Suko Hardjono; Iwan Syahrial Hamid


Journal of Mathematical and Fundamental Sciences | 2018

Molecular Docking of Ferulic Acid Derivatives on P2Y12 Receptor and their ADMET Prediction

Juni Ekowati; Nuzul Wahyuning Diyah; Kholis Amalia Nofianti; Iwan Sahrial Hamid; Siswandono Siswandono


Pharmaceutical Sciences and Research | 2017

Pemodelan Molekul Turunan p-Metoksi sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 dan Inhibitor Aromatase secara In silico

Galih Satrio Putra; Melanny Ika Sulistyowaty; Juni Ekowati; Tutuk Budiati


JPM17 | 2016

IbM KELOMPOK USAHA BUDIDAYA JAMUR DI KABUPATEN KEDIRI PASCA ERUPSI GUNUNG KELUD

Melanny Ika Sulistyowaty; Juni Ekowati; Achmad toto poernomo; M. Faris Adrianto


Procedia Chemistry | 2015

Antibacterial and Antioxidant Activity Evaluation of 1,3-Diaryl-prop-2-en-1-one Derivatives☆

Melanny Ika Sulistyowaty; Kholis Amalia Nofianti; Juni Ekowati; Galih Satrio Putra; Tri Widiandani; Tutuk Budiati


Berkala Ilmiah Kimia Farmasi | 2015

PENGARUH SUBSTITUEN 2-METOKSI PADA SINTESIS TURUNAN 2-HIDROKSIBENZOHIDRAZIDA DENGAN IRADIASI GELOMBANG MIKRO

Juni Ekowati; Marcellino Rudyanto; Gemilang Hardyanputrinda


Archive | 2014

SYNTHESIS AND ANTITUMOR ACTIVITY EVALUATION OF N,N' -DIBENZOYL-N,N' - DIETHYLUREA AGAINST HUMAN BREAST CANCER CELL LINE (MCF-7)

Nuzul Wahyuning Diyah; Juni Ekowati


Jurnal Farmasi dan Ilmu Kefarmasian | 2014

Sintesis Khalkon dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt dengan Iradiasi Gelombang Mikro

Kholis Amalia; S Melanny Ika; Juni Ekowati; Marcellino Rudyanto; Hadi Poerwono; Tutuk Budiati

Collaboration


Dive into the Juni Ekowati's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge