Juni Ekowati
Airlangga University
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Featured researches published by Juni Ekowati.
Journal of Ethnopharmacology | 2018
Idha Kusumawati; Kresma Oky Kurniawan; Subhan Rullyansyah; Tri Anggono Prijo; Retno Widyowati; Juni Ekowati; Eka Pramyrtha Hestianah; Suprapto Maat; Katsuyoshi Matsunami
ETHNOPHARMACOLOGICAL RELEVANCE Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use. MATERIALS AND METHODS The antioxidant activity was determined using the DPPH free radical method, and anti-aging activity was examined using in vitro assays such as tyrosinase inhibitor and collagenase inhibitor. In vivo tests were performed by observing histomorphologic changes in rat skin exposed to Ultraviolet (UV) rays. The total curcuminoid contents and chromatographic profiles were determined by Thin Layer Chromatography (TLC) - densitometry. RESULTS In all in vitro assays, all of the extracts showed a dose-dependent manner in the final concentration range from 62.5 to 500 µg/mL for DPPH assay and 31.25 to 250 µg/mL for tyrosinase inhibition and collagenase inhibition assay. Curcuminoid (CUR), the active principle of Curcuma genus shows antioxidant, tyrosinase inhibitor and collagenase inhibitor activity greater than all C. heyneana extracts. The in vivo assay results showed that the topical application of the crude extract of C. heyneana produced significant improvement effects on the UV-induced skin structure damage. The total CUR content was correlated with the anti-aging activity of Curcuma heyneana. CONCLUSIONS The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical.
Archive | 2014
Marcellino Rudyanto; Juni Ekowati; Tri Widiandani; Toshio Honda; Jalan Dharmawangsa Dalam
Universa Medicina | 2016
Juni Ekowati; Suko Hardjono; Iwan Syahrial Hamid
Journal of Mathematical and Fundamental Sciences | 2018
Juni Ekowati; Nuzul Wahyuning Diyah; Kholis Amalia Nofianti; Iwan Sahrial Hamid; Siswandono Siswandono
Pharmaceutical Sciences and Research | 2017
Galih Satrio Putra; Melanny Ika Sulistyowaty; Juni Ekowati; Tutuk Budiati
JPM17 | 2016
Melanny Ika Sulistyowaty; Juni Ekowati; Achmad toto poernomo; M. Faris Adrianto
Procedia Chemistry | 2015
Melanny Ika Sulistyowaty; Kholis Amalia Nofianti; Juni Ekowati; Galih Satrio Putra; Tri Widiandani; Tutuk Budiati
Berkala Ilmiah Kimia Farmasi | 2015
Juni Ekowati; Marcellino Rudyanto; Gemilang Hardyanputrinda
Archive | 2014
Nuzul Wahyuning Diyah; Juni Ekowati
Jurnal Farmasi dan Ilmu Kefarmasian | 2014
Kholis Amalia; S Melanny Ika; Juni Ekowati; Marcellino Rudyanto; Hadi Poerwono; Tutuk Budiati