Junichi Seki

Thyroid hormone abnormalities in patients with diabetes mellitus

Thyroid hormone abnormalities in serum were investigated in 47 patients with diabetes mellitus. Although no significant differences in T4 were found between normal subjects and diabetics, a group of diabetics whose fasting blood sugar levels were over 250 mg/dl showed significantly higher reverse T3(rT3) (p < 0.01) and lower T3 levels (p < 0.05) than healthy controls. A significant correlation was observed between rT3and FFA levels in diabetics. Moreover, patients in diabetic ketoacidosis showed markedly high rT3 with low T3 levels. With insulin treatment, these levels returned to normal in several days. These findings suggest that the reduction of T3and the increase of rT3 may indicate an adaptation to limit catabolism in diabetics.