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Featured researches published by Junko Endo.


Physiological Reports | 2015

Impact of ischemic preconditioning on functional sympatholysis during handgrip exercise in humans

Masahiro Horiuchi; Junko Endo; Dick H. J. Thijssen

Repeated bouts of ischemia followed by reperfusion, known as ischemic preconditioning (IPC), is found to improve exercise performance. As redistribution of blood from the inactive areas to active skeletal muscles during exercise (i.e., functional sympatholysis) is important for exercise performance, we examined the hypothesis that IPC improves functional sympatholysis in healthy, young humans. In a randomized study, 15 healthy young men performed a 10‐min resting period, dynamic handgrip exercise at 10% maximal voluntary contraction (MVC), and 25% MVC. This protocol was preceded by IPC (IPC; 4 × 5‐min 220‐mmHg unilateral occlusion) or a sham intervention (CON; 4 × 5‐min 20‐mmHg unilateral occlusion). Near‐infrared spectroscopy was used to assess changes in oxygenated hemoglobin and myoglobin in skeletal muscle (HbO2 + MbO2) in response to sympathetic activation (via cold pressor test (CPT)) at baseline and during handgrip exercise (at 10% and 25%). In resting conditions, HbO2 + MbO2 significantly decreased during CPT (−11.0 ± 1.0%), which was significantly larger during the IPC‐trial (−13.8 ± 1.2%, P = 0.006). During handgrip exercise at 10% MVC, changes in HbO2 + MbO2 in response to the CPT were blunted after IPC (−8.8 ± 1.5%) and CON (−8.3 ± 0.4%, P = 0.593). During handgrip exercise at 25% MVC, HbO2 + MbO2 in response to the CPT increased (2.0 ± 0.4%), whereas this response was significantly larger when preceded by IPC (4.2 ± 0.6%, P = 0.027). Collectively, these results indicate that IPC‐induced different vascular changes at rest and during moderate exercise in response to sympathetic activation. This suggests that, in healthy volunteers, exposure to IPC may alter tissue oxygenation during sympathetic stimulation at rest and during exercise.


International Journal of Environmental Research and Public Health | 2014

Impact of viewing vs. not viewing a real forest on physiological and psychological responses in the same setting.

Masahiro Horiuchi; Junko Endo; Norimasa Takayama; Kazutaka Murase; Norio Nishiyama; Haruo Saito; Akio Fujiwara

We investigated the impact of viewing versus not viewing a real forest on human subjects’ physiological and psychological responses in the same setting. Fifteen healthy volunteers (11 males, four females, mean age 36 years) participated. Each participant was asked to view a forest while seated in a comfortable chair for 15 min (Forest condition) vs. sitting the same length of time with a curtain obscuring the forest view (Enclosed condition). Both conditions significantly decreased blood pressure (BP) variables, i.e., systolic BP, diastolic BP, and mean arterial pressure between pre and post experimental stimuli, but these reductions showed no difference between conditions. Interestingly, the Forest viewing reduced cerebral oxygenated hemoglobin (HbO2) assessed by near-infrared spectroscopy (NIRS) and improved the subjects’ Profile of Mood States (POMS) scores, whereas the Enclosed condition increased the HbO2 and did not affect the POMS scores. There were no significant differences in saliva amylase or heart rate variability (HRV) between the two conditions. Collectively, these results suggest that viewing a real forest may have a positive effect on cerebral activity and psychological responses. However, both viewing and not viewing the forest had similar effects on cardiovascular responses such as BP variables and HRV.


Journal of Travel Medicine | 2016

Prevalence of acute mountain sickness on Mount Fuji: A pilot study

Masahiro Horiuchi; Junko Endo; Shin Akatsuka; Tadashi Uno; Thomas Edward Jones

BACKGROUND Few studies have investigated climbing-related acute mountain sickness (AMS) on Mt Fuji. Although several studies of AMS have been conducted elsewhere, Mt Fuji is unique because there are many mountain lodges between the fifth station (a common starting point for climbers at an altitude of 2305 m) and the summit (3776 m), and many climbers commonly sleep overnight at mountain lodges during their ascents. This study surveyed the prevalence of AMS among climbers on Mt Fuji to determine which factors, if any, were related to the risk of developing AMS. METHODS This study collected data from 345 participants who climbed Mt Fuji in August 2013, including information regarding age, sex, climbing experience and whether the climber stayed at a mountain lodge (n = 239). AMS was surveyed using the Lake Louise Score (LLS) questionnaire. The item on perceived sleep quality was excluded for those who did not stay at a mountain lodge (n = 106). RESULTS The overall prevalence of AMS was 29.5% (≥ 3 LLS with headache). According to a univariate analysis, AMS was not associated with sex (male vs female), age group (20-29, 30-39, 40-49 or >50 years) or stay at a mountain lodge (single day vs overnight stay). Conversely, prior experience climbing Mt Fuji (no prior attempts vs one or more prior attempts) was related to the risk of AMS. In addition, there was a significant deviation in the number of participants reporting poor sleep, and total sleep time was significantly shorter in participants with AMS. CONCLUSIONS These preliminary findings suggest that no single factor can explain the risk for developing AMS while climbing Mt Fuji. In addition, impaired perceived sleep quality was associated with the severity of AMS in climbers who stayed overnight at a mountain lodge.


Physiological Reports | 2017

Muscle oxygenation profiles between active and inactive muscles with nitrate supplementation under hypoxic exercise

Masahiro Horiuchi; Junko Endo; Shohei Dobashi; Yoko Handa; Masataka Kiuchi; Katsuhiro Koyama

Whether dietary nitrate supplementation improves exercise performance or not is still controversial. While redistribution of sufficient oxygen from inactive to active muscles is essential for optimal exercise performance, no study investigated the effects of nitrate supplementation on muscle oxygenation profiles between active and inactive muscles. Nine healthy males performed 25 min of submaximal (heart rate ~140 bpm; EXsub) and incremental cycling (EXmax) until exhaustion under three conditions: (A) normoxia without drink; (B) hypoxia (FiO2 = 13.95%) with placebo (PL); and (c) hypoxia with beetroot juice (BR). PL and BR were provided for 4 days. Oxygenated and deoxygenated hemoglobin (HbO2 and HHb) were measured in vastus lateralis (active) and biceps brachii (inactive) muscles, and the oxygen saturation of skeletal muscle (StO2; HbO2/total Hb) were calculated. During EXsub, BR suppressed the HHb increases in active muscles during the last 5 min of exercise. During EXmax, time to exhaustion with BR (513 ± 24 sec) was significantly longer than with PL (490 ± 39 sec, P < 0.05). In active muscles, BR suppressed the HHb increases at moderate work rates during EXmax compared to PL (P < 0.05). In addition, BR supplementation was associated with greater reductions in HbO2 and StO2 at higher work rates in inactive muscles during EXmax. Collectively, these findings indicate that short‐term dietary nitrate supplementation improved hypoxic exercise tolerance, perhaps, due to suppressed increases in HHb in active muscles at moderate work rates. Moreover, nitrate supplementation caused greater reductions in oxygenation in inactive muscle at higher work rates during hypoxic exercise.


Experimental Physiology | 2016

Effect of progressive normobaric hypoxia on dynamic cerebral autoregulation

Masahiro Horiuchi; Junko Endo; Shohei Dobashi; Masataka Kiuchi; Katsuhiro Koyama; Andrew W. Subudhi

What is the central question of this study? Acute hypoxia reduces dynamic cerebral autoregulation (dCA); however, it is unclear what level of hypoxia is necessary to exert this effect. We sought to investigate whether dCA would be reduced during progressive periods of normobaric hypoxia using a duplex Doppler ultrasound technique to evaluate the volumetric blood flow. What is the main finding and its importance? We showed that dCA decreased linearly as inspired O2 decreased from 21 to 12%. Additionally, symptoms of acute mountain sickness were related to changes in dCA. Our results may provide a sensitive and clinically relevant test to evaluate the risk of acute mountain sickness.


Journal of Physical Therapy Science | 2015

An effective strategy to reduce blood pressure after forest walking in middle-aged and aged people

Masahiro Horiuchi; Junko Endo; Shin Akatsuka; Tatsuya Hasegawa; Eriko Yamamoto; Tadashi Uno; Sachiko Kikuchi

[Purpose] Forest walking may be effective for human health, but little information is available about effects of energy expenditure on blood pressure responses after forest walking. The aim of this study was to investigate the relationship between the activity energy expenditure and changes in blood pressure in individuals after forest walking. [Subjects] The subjects were 54 middle-aged and elderly people. [Methods] All subjects walked in the forest for approximately 90 min. Blood pressure, salivary amylase, and the Profile of Mood States were evaluated before and after forest walking, and activity energy expenditure was monitored throughout forest walking. Subjects were divided into two groups according to mean arterial pressure changes: a responder group (>5% decreases) and a nonresponder group (<5%). [Results] Forest walking significantly reduced the mean arterial pressure and improved the Profile of Mood States in both groups. Activity energy expenditure was related to changes in mean arterial pressure in the responder group, while this relation was not observed in the nonresponder group. Differential activity energy expenditure did not strongly affect improvement of the Profile of Mood States. [Conclusion] Greater walking-related greater activity energy expenditure might be required to accentuate physiological beneficial effects on in middle-aged and aged people. Furthermore, the forest environment per se can attenuate psychological stress.


Advances in Experimental Medicine and Biology | 2016

Reduction in Cerebral Oxygenation After Prolonged Exercise in Hypoxia is Related to Changes in Blood Pressure

Masahiro Horiuchi; Shohei Dobashi; Masataka Kiuchi; Junko Endo; Katsuhiro Koyama; Andrew W. Subudhi

We investigated the relation between blood pressure and cerebral oxygenation (COX) immediately after exercise in ten healthy males. Subjects completed an exercise and recovery protocol while breathing either 21% (normoxia) or 14.1% (hypoxia) O2 in a randomized order. Each exercise session included four sets of cycling (30 min/set, 15 min rest) at 50% of altitude-adjusted peak oxygen uptake, followed by 60 min of recovery. After exercise, mean arterial pressure (MAP; 87±1 vs. 84±1 mmHg, average values across the recovery period) and COX (68±1% vs. 58±1%) were lower in hypoxia compared to normoxia (P<0.001). Changes in MAP and COX were correlated during the recovery period in hypoxia (r=0.568, P<0.001) but not during normoxia (r=0.028, not significant). These results demonstrate that reductions in blood pressure following exercise in hypoxia are (1) more pronounced than in normoxia, and (2) associated with reductions in COX. Together, these results suggest an impairment in cerebral autoregulation as COX followed changes in MAP more passively in hypoxia than in normoxia. These findings could help explain the increased risk for postexercise syncope at high altitude.


Biology of Sport | 2018

Jump training with blood flow restriction has no effect on jump performance

Masahiro Horiuchi; Junko Endo; Takashi Sato; Koichi Okita

This study investigated whether jump training with blood flow restriction (BFR) improves jump performance compared to jump training without BFR under similar exercise intensity in healthy young humans. The participants were twenty healthy males who were assigned to either jump training with BFR (n = 10) or jump training without BFR [control (CON); n = 10] groups. All subjects completed five sets of 10 repetitions with one-minute intervals of half-squat jumps (SJ) at maximal effort, four days a week for four weeks. In the BFR group, circulatory occlusion around both thigh muscles was applied at a pressure of 200 mmHg, and physical characteristics, muscle strength and jump performance were evaluated before and after training. A significant main effect of training period on lean body mass, percentage of body fat and leg circumference in both groups was observed (P < 0.05). For jump training with BFR, only knee flexion strength increased (P < 0.05), while in the CON group, both knee extension and flexion strength increased (P < 0.05). BFR training did not improve SJ or counter-movement jumps (CMJ) (P > 0.05), whereas training without BFR (CON) improved the performance of both jumps (SJ: pre 35.7 ± 5.1 vs. post 38.9 ± 4.1 cm, P = 0.002: CMJ: pre 41.6 ± 3.6 vs. post 44.6 ± 3.8 cm, P < 0.001). These results indicate that jump training with BFR may not be an effective strategy for improving jump performance.


BioMed Research International | 2017

Impact of Carbohydrate-Electrolyte Beverage Ingestion on Heart Rate Response While Climbing Mountain Fuji at ~3000 m

Masahiro Horiuchi; Junko Endo; Koichi Kondo; Tadashi Uno; Mayuko Morikawa

We sought to investigate whether carbohydrate-electrolyte beverage ingestion reduced heart rate (HR) in twenty-three healthy young adults while climbing Mount Fuji at a given exercise intensity. Twenty-three healthy adults were randomly divided into two groups: the tap water (11 males [M] and 1 female [F]) and the carbohydrate-electrolyte group (10 M and 1 F). HR and activity energy expenditure (AEE) were recorded every min. The HRs for the first 30 minutes of climbing were not significantly different between the groups [121 ± 2 beats per min (bpm) in the tap water and 116 ± 3 bpm in the carbohydrate-electrolyte]; however, HR significantly increased with climbing in the tap water group (129 ± 2 bpm) but showed no significant increase in the carbohydrate-electrolyte group (121 ± 3 bpm). In addition, body weight changes throughout two days ascending and descending on Mount Fuji were inversely related to changes in resting HR. Further, individual variation of body weight changes was suppressed by carbohydrate-electrolyte drink. Collectively, carbohydrate-electrolyte beverage intake may attenuate an increase in HR at a given AEE while mountaineering at ~3000 m compared with tap water intake.


Journal of Exercise Science & Fitness | 2015

Comparisons of energy cost and economical walking speed at various gradients in healthy, active younger and older adults

Masahiro Horiuchi; Junko Endo; Yukari Horiuchi; Daijiro Abe

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Masahiro Horiuchi

Hokkaido University of Education

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Shin Akatsuka

Kochi University of Technology

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Andrew W. Subudhi

University of Colorado Colorado Springs

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Dick H. J. Thijssen

Liverpool John Moores University

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Daijiro Abe

Kyushu Sangyo University

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