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Featured researches published by Junko Ishida.


Bioorganic & Medicinal Chemistry | 2002

Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.

Junko Ishida; Hironori Ohtsu; Yoko Tachibana; Yuka Nakanishi; Kenneth F. Bastow; Masahiro Nagai; Hui Kang Wang; Hideji Itokawa; Kuo Hsiung Lee

Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively.


Bioorganic & Medicinal Chemistry | 2002

Chemopreventive potential of cyclic diarylheptanoids

Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo Hsiung Lee; Masahiro Nagai

Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors.


Journal of Medicinal Chemistry | 2002

Antitumor Agents. 217. † Curcumin Analogues as Novel Androgen Receptor Antagonists with Potential as Anti-Prostate Cancer Agents

Hironori Ohtsu; Zhiyan Xiao; Junko Ishida; Masahiro Nagai; Hui Kang Wang; Hideji Itokawa; Ching Yuan Su; Charles C.Y. Shih; Tzuying Chiang; Eugene B. Chang; Yi-Fen Lee; Meng Yin Tsai; Chawnshang Chang; Kuo Hsiung Lee


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1997

A New Triterpenoid Myricalactone and Others from Myrica gale var. tomentosa

Nobuko Sakurai; Yasushi Hosono; Motohiko Morihara; Junko Ishida; Ken-ichi Kawai; Takao Inoue; Masahiro Nagai


Archive | 2010

NEW CURCUMINE ANALOGUE AND USE OF THE SAME

Chawnshang Chang; Junko Ishida; Hideji Itokawa; Kuo-Hsiung Lee; Hironari Ohtsu; Charles C.Y. Shih; Hui-Kang Wang; オオツ,ヒロナリ; シー,チャールズ・シー・ワイ; チャン,チョンシャン; リー,クオ‐シュン; ワン,フイ‐カン; 順子 石田; 秀治 糸川


Archive | 2005

Neue curcuminanaloge und verwendungen dafür

Kuo-Hsiung Lee; Li Lin; Charles C.Y. Shih; Ching-Yuan Su; Junko Ishida; Hironori Ohtsu; Hui-Kang Wang; Hideji Itokawa; Chawnshang Chang


Archive | 2005

Nouveaux analogues de curcumine et leurs utilisations

Chawnshang Chang; Junko Ishida; Hideji Itokawa; Kuo-Hsiung Lee; Li Lin; Hironori Ohtsu; Charles C.Y. Shih; Ching-Yuan Su; Hui-Kang Wang


Archive | 2003

Nouveaux analogues de curcumine et utilisations de ces derniers

Chawnshang Chang; Junko Ishida; Hideji Itokawa; Kuo-Hsiung Lee; Hironari Ohtsu; Charles C.Y. Shih; Hui-Kang Wang


Archive | 2003

Analogues de curcumine et utilisations de ces derniers

Kuo Hsiung Lee; Junko Ishida; Hironari Ohtsu; Hui-Kang Wang; Hideji Itokawa; Chawnshang Chang; Charles C.Y. Shih


Archive | 2003

New curcuminanaloga and their applications

Kuo-Hsiung Lee; Junko Ishida; Hironori Ohtsu; Hui-Kang Wang; Hideji Itokawa; Chawnshang Chang; Charles C.Y. Shih

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Hideji Itokawa

University of North Carolina at Chapel Hill

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Charles C.Y. Shih

University of Wisconsin-Madison

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Chawnshang Chang

University of North Carolina at Chapel Hill

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Hui-Kang Wang

University of North Carolina at Chapel Hill

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Hironori Ohtsu

University of North Carolina at Chapel Hill

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Kuo-Hsiung Lee

Kyoto Pharmaceutical University

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Kuo Hsiung Lee

University of North Carolina at Chapel Hill

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Hironari Ohtsu

University of North Carolina at Chapel Hill

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Ching-Yuan Su

Southern Illinois University School of Medicine

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