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Junying Zheng

Schering-Plough

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Publication

Featured researches published by Junying Zheng.

Journal of Medicinal Chemistry | 2014

Adenosine A2A receptor as a drug discovery target.

Manuel de Lera Ruiz; Yeon-Hee Lim; Junying Zheng

The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the most relevant series of adenosine A2A agonists and antagonists. This review also provides an update of the A2A ligands that are undergoing or have undergone clinical studies, including the two currently marketed agonists adenosine and regadenoson.

Archive | 2006

Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists

Mwangi W. Mutahi; Robert G. Aslanian; Michael Y. Berlin; Christopher W. Boyce; Manuel de Lera Ruiz; Kevin D. Mccormick; Daniel M. Solomon; Henry A. Vaccaro; Junying Zheng; Purakkattle J. Biju; Younong Yu; Wei Zhou; Xiaohong Zhu

Archive | 2004

Thiadiazoles AS CXC- and CC- chemokine receptor ligands

Purakkattle J. Biju; Arthur G. Taveras; J. Robert Merritt; John J. Baldwin; Younong Yu; Junying Zheng; Jianhua Chao; Cynthia J. Aki

Archive | 2004

Isothiazole dioxides as CXC- and CC-chemokine receptor ligands

Arthur G. Taveras; J. Robert Merritt; John J. Baldwin; Junying Zheng; Purakkattle J. Biju; Younong Yu; Jianhua Chao; Gaifa Lai; Minglang Wu

Archive | 2006

Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine h3 antagonists

Robert G. Aslanian; Michael Y. Berlin; Christopher W. Boyce; Jianhua Chao; Manuel de Lera Ruiz; Pietro Mangiaracina; Kevin D. Mccormick; Mwangi W. Mutahi; Stuart B. Rosenblum; Neng-Yang Shih; Daniel M. Solomon; Wing C. Tom; Henry A. Vaccaro; Junying Zheng; Xiaohong Zhu

Archive | 2009

Tricyclic spirocycle derivatives and methods of use thereof

Kevin D. Mccormick; Robert G. Aslanian; Pietro Mangiaracina; Michael Y. Berlin; Christopher W. Boyce; Jianhua Chao; Pauline C. Ting; Junying Zheng; Stuart B. Rosenblum

Archive | 2008

3,4-dihydr0-l,4-benz0xazine, 3, 4-dihydr0-1, 4-benzothiazine and 1,2,3,4-tetrahydro-quinoxaline derivatives as alpha2c adrenoreceptor agonists

Kevin D. Mccormick; Christopher W. Boyce; Neng-Yang Shih; Robert G. Aslanian; Salem Fevrier; Pietro Mangiaracina; Younong Yu; Junying Zheng; Chia-Yu Huang; Bo Liang; Rong-Qiang Liu; Ruiyan Liu; Zawacki Lisa Guise

Complications in Anesthesia (Second Edition) | 2007

α2C adrenoreceptor agonists

Kevin D. Mccormick; Christopher W. Boyce; Neng-Yang Shih; Chia-Yu Huang; Robert G. Aslanian; Salem Fevrier; Bo Liang; Rong-Qiang Liu; Ruiyan Liu; Pietro Mangiaracina; Manuel de Lera Ruiz; Younong Yu; Lisa Guise-Zawacki; Junying Zheng

Tetrahedron Letters | 2007

A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems

Jianhua Chao; Mariam Israiel; Junying Zheng; Cynthia J. Aki

Archive | 2014

PIPERAZINE-SUBSTITUTED 7-METHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Amjad Ali; Michael Man-Chu Lo; Yeon-Hee Lim; Andrew Stamford; Rongze Kuang; Paul Tempest; Younong Yu; Michael Y. Berlin; Pauline Ting; Gang Zhou; Tao Yu; Christopher W. Boyce; Joseph M. Kelly; Jayaram R. Tagat; Junying Zheng; Xianhai Huang; Wei Zhou; Jae-Hun Kim; Nicolas Zorn; Dong Xiao; Gioconda V. Gallo; Walter Won; Heping Wu; Rajan Anand

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Collaboration

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Robert G. Aslanian

Schering-Plough

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Kevin D. Mccormick

Schering-Plough

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Michael Y. Berlin

Schering-Plough

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Christopher W. Boyce

Schering-Plough

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Jianhua Chao

Schering-Plough

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Pietro Mangiaracina

Schering-Plough

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Younong Yu

Schering-Plough

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Neng-Yang Shih

Schering-Plough

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Mwangi W. Mutahi

Schering-Plough

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Stuart B. Rosenblum

Schering-Plough

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