Jürgen Mack
Boehringer Ingelheim
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Publication
Featured researches published by Jürgen Mack.
Organic Letters | 2014
Zhengxu S. Han; Yibo Xu; Daniel R. Fandrick; Sonia Rodriguez; Zhibin Li; Bo Qu; Nina C. Gonnella; Sanjit Sanyal; Jonathan T. Reeves; Shengli Ma; Nelu Grinberg; Nizar Haddad; Dhileep Krishnamurthy; Jinhua J. Song; Nathan K. Yee; Waldemar Pfrengle; Markus Ostermeier; Jürgen Schnaubelt; Zeno A. Leuter; Sonja Steigmiller; Jürgen Däubler; Emanuel Stehle; Lukas Neumann; Thomas Trieselmann; Patrick Tielmann; Annette Buba; Rainer Hamm; Gunter Koch; Svenja Renner; Juan R. Dehli
An efficient enantioselective synthesis of the chiral polycyclic cholesteryl ester transfer protein (CETP) inhibitor 1 has been developed. The synthesis was rendered practical for large scale via the development of a modified Hantzsch-type reaction to prepare the sterically hindered pyridine ring, enantioselective hydrogenation of hindered ketone 6 utilizing novel BIBOP-amino-pyridine derived Ru complex, efficient ICl promoted lactone formation, and a BF3 mediated hydrogenation process for diastereoselective lactol reduction. This efficient route was successfully scaled to produce multikilogram quantities of challenging CETP drug candidate 1.
Journal of Natural Products | 2004
Olivier Potterat; Klaus Wagner; Gerd Gemmecker; Jürgen Mack; Carsten Puder; Regine Vettermann; Rüdiger Streicher
Archive | 2005
Christoph Hoenke; Klaus Rudolf; Thierry Bouyssou; Ingo Konetzki; Philipp Lustenberger; Jürgen Mack; Andreas Schnapp; Dieter Wiedenmayer
Archive | 2010
Ingo Konetzki; Angelo Ceci; Henri Doods; Norbert Hauel; Jürgen Mack; Henning Priepke; Annette Schuler-Metz; Rainer Walter
Archive | 2004
Rüdiger Streicher; Jürgen Mack; Rainer Walter; Ingo Konetzki; Thomas Trieselmann; Volkhard Austel
Archive | 2006
Horst Dollinger; Birgit Jung; Jürgen Mack; Domnic Martyres; Peter Nickolaus
Archive | 2004
Olivier Potterat; Rüdiger Streicher; Klaus Wagner; Till Maurer; Jürgen Mack; Stefan Peters
Archive | 2010
Ingo Konetzki; Angelo Ceci; Henri Doods; Norbert Hauel; Jürgen Mack; Henning Priepke; Annette Schuler-Metz; Rainer Walter
Archive | 2005
Thierry Bouyssou; Christoph Hoenke; Ingo Konetzki; Jürgen Mack; Andreas Schnapp
Archive | 2005
Peter Nickolaus; Christopher John Montague Meade; Horst Dollinger; Jürgen Mack; Georg Dahmann; Domnic Martyres; Birgit Jung
