Justin Santarelli

Cervical spondylotic myelopathy: complications and outcomes after spinal fusion.

OBJECTIVE There is little information about in-hospital complication rates, adverse outcomes, and mortality after spinal fusion for cervical spondylotic myelopathy (CSM). The aim of this study was to report inpatient mortality, complications, and outcomes on a national level. METHODS We used the National Inpatient Sample to identify 58,115 admissions of patients with CSM who underwent spinal fusion in the United States from 1993 to 2002. Multivariate analysis was performed to analyze the effects of patient and hospital characteristics on outcomes such as mortality, complications, discharge disposition, and length of stay. RESULTS A total of 58,115 patients with CSM underwent spinal fusion with an average mortality rate of 0.6%, a complication rate of 13.4%, and a mean length of stay of 4 days. Pulmonary (3.6%) and postoperative hemorrhages or hematomas (2.3%) were the most common complications reported. One postoperative complication led to a 4-day increase in mean length of stay, increased the mortality rate 20-fold, and added more than

National inpatient complications and outcomes after surgery for spinal metastasis from 1993–2002

10,000 to hospital charges. Multivariate analysis identified age, comorbidity, and admission type as the main predictors of mortality, complication rate, and adverse outcome. Patients aged > or =85 or 65 to 84 years had respective 44- and 14-fold increases in mortality, compared with patients in the 18- to 44-year age group. Patients older than 84 years had a 40-fold increase in adverse outcomes and a 5-fold likelihood of medical complications. Patients with three or more comorbidities had an increased risk of medical complications (odds ratio [OR], 1.98), adverse discharge (OR, 2.17), and in-hospital mortality (OR, 2.36). Elective admissions were associated with much lower rates of mortality (OR, 0.28), complication (OR, 0.68), and adverse outcome (OR, 0.26). Complications were greater for posterior fusion (16.4%) versus anterior fusion (11.9%) procedures. Anterior fusions were associated with a greater incidence of dysphagia (3%) and hoarseness (0.21%). Cervical spondylosis patients who presented without myelopathy had a much lower incidence of complications (6.3%). CONCLUSIONS We provide a national estimate of inpatient complications and outcomes after spinal fusion for CSM patients in the United States. We demonstrate the impacts of age, complications, and medical comorbidities on the outcome of surgery for patients with this common disorder. We provide complication rates stratified by age and medical comorbidities for elderly patients who present with CSM who need spinal fusion.

National trends in spinal fusion for cervical spondylotic myelopathy

Information regarding patient outcomes, complications, and mortality after surgery for spinal metastasis has previously been derived from single‐institution series. The aim of this study was to report inpatient mortality, complications, and outcomes on a national level.

Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain

BACKGROUND The objective of this study is to provide a retrospective analysis using an NIS database to examine national trends in outcomes for CSM from 1993 to 2002. METHODS Data for CSM admissions (n = 138792) were extracted from the 1993 to 2002 NIS database to determine overall outcomes, as well as for those patients with CSM who underwent spinal fusion. Data from 1993 to 1997 (period 1) were compared with data from 1998 to 2002 (period 2). RESULTS The number of patients admitted with CSM increased 2-fold from 3.73 to 7.88 per 100000 US population. Approximately 10% of patients were admitted from the ED and 42% underwent spinal fusion. The number of patients with CSM that underwent spinal fusion increased 7-fold from 0.6 to 4.1 per 100000 people over the period from 1993 to 2002. Most spinal fusions were performed in the 45- to 64-year age group. The number of patients with 2 or more comorbidities increased from 20% to 37%; however, the mortality and adverse outcome rates remained stable, and there was a slight decrease in LOS. CONCLUSIONS Cervical spondylotic myelopathy is one of the most common disorders treated by spine surgeons. There was a nearly 7-fold increase in the number of spinal fusions for CSM from 1993 to 2002. Despite continued increases in patient medical comorbidities, overall complication rates have remained stable at approximately 10.3% and mortality rates constant at 0.6%.

Inpatient complications, mortality, and discharge disposition after surgical correction of idiopathic scoliosis: a national perspective

OBJECTIVE:Neoangiogenesis is a prerequisite for the full phenotypic expression and growth of a malignant tumor mass. It is believed to be triggered by tissue hypoxia and involves proliferation and sprouting of the preexisting vessels and the recruitment of endothelial progenitor cells from bone marrow. METHODS:A chimeric mouse model was used to examine the contribution of these progenitor cells to the neovasculature of brain tumor. T-cell knockout (RAG/KO5.2) mice were irradiated lethally, and their bone marrow was repopulated with T-cell depleted green fluorescent protein (GFP)-expressing bone marrow cells. RAG/RT-2 glioma cells were implanted into the striatum of the animals. Neovascular formation at various times of tumor growth was monitored together with the extent of incorporation of GFP+ bone marrow-derived cells within the vascular tree, in particular, cells carrying the endothelial progenitor markers CD34 and Flk-1. RESULTS:The recruitment of GFP+ cells to the growing tumor and their incorporation into the vascular network occurred during the period of increasing vascular density and preceded the expansion of the tumor. The number of marrow-derived cells with endothelial morphology and phenotype was small but significant (4% of all endothelial cells at Day 12); 54% of all tumor vessels contained at least one GFP+ cell. CONCLUSION:Our results suggest that bone marrow cells are recruited to newly formed and remodeled tumor vessels. Their recruitment may occur in response to signals from a highly proliferating milieu, and their role is to support the neovascular complex and to promote tumor growth.

National trends in spinal arteriovenous malformations

BACKGROUND CONTEXT Information about complications and mortality after surgery for correction of idiopathic scoliosis has been largely derived from single-institution series. Regional or national studies have been lacking. PURPOSE To report inpatient mortality, complications, and discharge disposition after surgical correction of idiopathic scoliosis on a national level. STUDY DESIGN Retrospective cohort study using National Inpatient Sample (NIS) administrative data. PATIENT SAMPLE All patients in the NIS with the primary diagnosis of idiopathic scoliosis who underwent a spinal fusion between 1993 and 2002 were included. OUTCOME MEASURES Inpatient complication rate, mortality rate, and adverse outcome defined by death or discharge to institution other than home. METHODS Outcome measures were abstracted from the NIS. Univariate and multivariate analyses were performed to analyze the effects of patient and hospital characteristics on outcome measures. RESULTS The NIS was used to identify 51,911 patients who underwent spinal fusion for idiopathic scoliosis in the United States from 1993 to 2002. The total inhospital complication rate was 14.9% for pediatric patients and 25.1% for adult patients. The inhospital mortality rate was 0.17% and 0.40% for pediatric and adult patients, respectively. Adverse outcome was noted in 2.3% of pediatric patients and 20.4% of adult patients. Pulmonary and postoperative hemorrhages/hematomas were the most common complications reported. Multivariate analysis for complications showed that morbidity was significantly lower for pediatric patients (odds ratio [OR] = 0.80; confidence interval [CI] = 0.68-0.94) and female patients (OR = 0.77; CI = 0.68-0.88). Patients with a preoperative comorbidity were 1.53 (CI = 1.32-1.76) times more likely to develop a complication. A single postoperative complication increased the mean length of stay by more than 2 days and increased the mortality rate, adverse outcome, and hospital charges significantly. CONCLUSIONS We have provided a national perspective on inpatient complications, mortality, and discharge disposition after spinal fusion for idiopathic scoliosis in the United States. The significant negative effects of postoperative complications on mortality and resource utilization have been demonstrated. Furthermore, we have identified adult age, male gender, and preoperative comorbidity as important risk factors and defined their impact on patient outcomes.

The temporal–spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture

OBJECT Spinal arteriovenous malformations (AVMs) are rare and understudied vascular lesions that cause neurological insult by mass effect, venous obstruction, and vascular steal. These lesions are challenging entities to treat because of their complicated anatomy and physiology. Current management options include open microsurgery, endovascular embolization, and stereotactic radiosurgery. METHODS Our study used the National Inpatient Sample database to analyze outcome data for spinal AVMs treated nationwide over an 11-year period from 1995 through 2006. Trends in procedural management, hospital course, and epidemiology of spinal AVMs are investigated. RESULTS Annually, an average of 300 patients presented with spinal AVMs requiring hospital treatment. The average length of hospital stay for this treatment has declined from more than 9 days in 1995 to 6 days in 2006. However, the average cost of a hospital stay has increased from <

Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone-marrow-derived endothelial precursor cells into brain tumors.

30,000 to nearly

Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor.

70,000. Whereas one-half of spinal AVMs were treated operatively in 1995, one-third were managed operatively in 2006. CONCLUSIONS Spinal AVMs are being increasingly treated by endovascular, radiosurgical, or combined means. A discussion of modern strategies to treat these disorders is presented.

Laminectomy and fusion after spinal cord injury: national inpatient complications and outcomes.

Abstract Angiopoietins play a pivotal role in tumor angiogenesis by modulating vascular endothelial proliferation and survival. The expression of angiopoietins 1 and 2 (Ang-1 and Ang-2) and vascular endothelial growth factor (VEGF) has been documented in human malignant glioma. The expression of Ang-1, Ang-2, VEGF, and Tie-2, a member of the receptor tyrosine kinases and the natural receptor for both Ang-1 and Ang-2, follows a distinct transcriptional profile in vivo. Ang-2 and VEGF were expressed early in tumor formation and their levels increased throughout tumor growth. Their expression coincided with the expansion of the tumor mass and the formation of the vascular tree. There was no significant change in the expression of Tie-2 and Ang-1. The expression of Ang-1 and Tie-2 was more noticeable at the periphery of the tumor. The expression of Ang-2 was more robust at the periphery and within the tumor mass, and VEGF was more concentrated within the center of the tumor. This distinct expression profile may explain the morphology of the newly formed vessels at various times and regions of the tumor. The lack of concomitant expression of Ang-1 may underscore the unopposed endovascular induction by Ang-2 and VEGF resulting in the chaotic appearance and fragility of tumor vessels.