Justine L. Drakeford
Staffordshire University
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Featured researches published by Justine L. Drakeford.
Psychopathology | 2006
Justine L. Drakeford; Nicola M.J. Edelstyn; Femi Oyebode; Shrikant Srivastava; William R. Calthorpe; Tirthankar Mukherjee
Background: Dual-process models propose that recognition memory (RM) involves two processes: conscious recollection and familiarity-aware memory. Studies investigating RM in schizophrenia report a selective deficit in conscious recollection and intact levels of familiarity-driven RM for stimuli presented in the visual and olfactory domains. It has been suggested that abnormalities in conscious recollection result from a breakdown in frontal strategic memory processes involved in encoding and retrieval and executive functions linked to reality monitoring and decision making. We investigated three predictions arising from these proposals. Firstly, if conscious recollection abnormalities arise from a central impairment, then these abnormalities should not be domain specific. Secondly, if the deficits in conscious recollection arise from a breakdown in executive processes, deficiencies should be correlated with executive dysfunction. Finally, the conscious recollection deficiencies are likely to be more severe in schizophrenia, a condition associated with marked executive dysfunction relative to Major Depressive Disorder, Recurrent (MDDR), in which executive dysfunction is less marked. Methods: The remember/know paradigm was used to investigate RM for voices in three groups: patients with schizophrenia (n = 14), patients with MDDR (n = 16), and normal controls (n = 16). Executive function was assessed using the Wisconsin Card Sorting Task. Results: Patients with schizophrenia made significantly fewer remember responses than normal controls (p < 0.01), despite normal levels of discrimination and familiarity-driven auditory RM. Patients with MDDR did not differ significantly from either normal controls or patients with schizophrenia. Executive dysfunction was limited to the schizophrenia group and was not correlated with conscious recollection deficiencies. Conclusions: Patients with schizophrenia exhibit a deficit in conscious recollection for auditory RM of voices. These findings, when considered alongside remember/know data collected from the same set of patients for olfactory and visual RM, support proposals that abnormalities in conscious recollection stem from a breakdown in central rather than domain-specific processes.
Psychopathology | 2003
Nicola M.J. Edelstyn; Justine L. Drakeford; Femi Oyebode; Chris Findlay
Background: Recognition memory (RM) is impaired in patients with schizophrenia, as they rely largely on feelings of familiarity rather than conscious recollection. It has been suggested that this abnormality may reflect a breakdown in strategic memory processes involved in both encoding and retrieval. By studying 2 patients with false recognition (FR; patient C.T.) and delusional misidentification (DM; patient B.C.), and a group of psychotic control patients, we examined proposals that FR and DM exist on a continuum of increasingly severe impairment in strategic memory function. Methods: Executive function, autobiographical memory and verbal and facial RM were assessed using standard neuropsychological tests and the remember/know paradigm. Results: The psychotic control group displayed a significantly reduced reliance on remember judgements and compensatory elevation in know judgements on both RM tasks compared with the normal control group. Patient B.C. also followed this trend, but in a much more pronounced manner. In contrast, patient C.T. displayed a qualitatively different performance profile, which was marked by an increased dependence on remember responses. Conclusions: We have presented evidence which support proposals that a breakdown in strategic memory and executive dysfunction are more pronounced in DM than FR. However, the small sample size precludes any firm conclusions being drawn.
Acta Neuropsychiatrica | 2003
Nicola M.J. Edelstyn; Justine L. Drakeford; Femi Oyebode; Chris Findlay
Background: Recognition memory dysfunction has been frequently reported in schizophrenic populations, and has been linked with the development of delusions and thought disorder. A range of neuropsychological abnormalities have also been documented in the biological asymptomatic relatives of patients with schizophrenia; however, recognition memory has not been one of them. Aim: This study was carried out in order to investigate: (i) verbal and facial recognition memory in terms of accuracy and false alarm rates; and (ii) contributions from the episodic and semantic memory systems to recognition memory, in the biological asymptomatic parents of a reported schizophrenic patient and a set of male and female psychotic controls. Results: Gender differences failed to emerge between the psychotic controls on any of the recognition measures (discrimination accuracy, response bias, hit and false alarm rates, ‘remember’ and ‘know’ recognition memory decisions). However, there was evidence of recognition dysfunction in the female relative, and to a lesser extent, in the male. Both parents recognition memory performance profiles were marked by a pathologically elevated false alarm rate, and an increased dependence ‘remember’ judgements, i.e. input from the episodic memory system, to drive recognition memory decisions. Conclusions: These findings are discussed in the context of models of episodic and semantic memory impairment in schizophrenia.
Psychopathology | 2003
Séverine Ducrey; Marianne Gex-Fabry; Alexandre Dayer; Emna Ragama Pardos; Shuji Honjo; Shiori Arai; Hitoshi Kaneko; Tatsuo Ujiie; Michael Bach; Patrick Hardy; Barbara Kaup-Eder; Bernd Saletu; Loraine Roth; Jean-Michel Aubry; Gilles Bertschy; Nicola M.J. Edelstyn; Justine L. Drakeford; Femi Oyebode; Chris Findlay; Nizar Hatem; Claire Damy; Bruno Falissard; J.-D. Guelfi; Michel Reynaud; Emmanuelle Corruble; Satomi Murase; Haya Sechiyama; Yasuko Sasaki; Chie Hatagaki; Eri Inagaki
Medical and Scientifi c Publishers Basel • Freiburg • Paris • London New York • Bangalore • Bangkok Singapore • Tokyo • Sydney Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant fl ow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specifi ed fee to the Copyright Clearance Center (see ‘General Information’).
Consciousness and Cognition | 2009
Paul M. Jenkinson; Nicola M.J. Edelstyn; Justine L. Drakeford; Simon J. Ellis
Cortex | 2015
Nicola M.J. Edelstyn; Christopher M. John; Thomas A. Shepherd; Justine L. Drakeford; David Clark-Carter; Simon J. Ellis; Andrew R. Mayes
Archive | 2003
Justine L. Drakeford; Nicola M.J. Edelstyn; Femi Oyebode; Shrikant Srivastava; Tirthankar Mukherjee
Archive | 2014
Nicola M.J. Edelstyn; Justine L. Drakeford; Simon J. Ellis
Behavioural Neurology | 2010
Paul M. Jenkinson; Nicola M.J. Edelstyn; Justine L. Drakeford; Christine Roffe; Simon J. Ellis
Archive | 2007
Justine L. Drakeford; Nicola M.J. Edelstyn; Femi Oyebode; William R. Calthorpe; Shrikant Srivastava; Tirthankar Mukherjee