Jyoti Agarwal

Glucosamine-Based Primary Amines as Organocatalysts for the Asymmetric Aldol Reaction

Glucosamine derivatives have been synthesized starting from commercially available N-acetyl-D-glucosamine/glucosamine hydrochloride and have been employed successfully as efficient organocatalysts for the direct asymmetric aldol reaction between cyclohexanone and aryl aldehydes having diversified substituents. Furthermore, the anomeric effect of various groups present at the anomeric position on the catalytic activity of these organocatalysts was also studied.

Magnesium Chloride–Catalyzed Thiolysis of Epoxides: Synthesis of β-hydroxy Sulfides

A mild and convenient ring opening of epoxides with thiophenol and its derivatives takes place at room temperature in the presence of magnesium chloride as catalyst to afford the corresponding β-hydroxy sulfides along with minor amounts of 2-chlorocycloalkanols in good yields. When the crude reaction mixtures are treated with aqueous sodium hydroxide solution, pure 2-arlythiocycloalkanols are obtained in good yields.

An expedient and green protocol for the Michael addition of malonates, diketones and β-keto esters to the nitrostyrenes

A novel method for the rapid synthesis of functionalized nitroalkanes by addition of less reactive carbon nucleophiles to various trans-β-nitrostyrenes under solvent-free reaction conditions is developed.