K. A. Nirmala

Methyl 2-(acetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

The title compound, C12H15NO3S, exhibits antibacterial and antifungal activities. The cyclohexene ring exhibits disorder,indicating two possible conformations of the half-chair form.The molecular structure is approximately planar, supported byan intramolecular N–H...O hydrogen bond.

2-Amino-N-(2-chlorophenyl)-4,5,6,7-tetra-hydro-1-benzothiophene-3-carboxamide

The title compound,

Two biologically active thiophene- 3-carboxamide derivatives

{C_{15}H_{15}ClN_{2}OS}

2-[( E )-(4-Hydroxy-3-methoxybenzylidene)amino]- N -(2-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

, shows antibacterial and antifungal activities. The dihedral angle between the thiophene moiety and the 2-chlorophenyl ring is

4,5-Dimethyl-N-(2-methylphenyl)-2-

22.3(1)^{mathtrm{0}}

\{[(1E)-(3,4,5-trimethoxyphenyl)methylene]amino\}

. There are intramolecular N–H...O and N–H... Cl hydrogen bonds and an intramolecular C–H...O interaction, which remove the conformational fexibility. Also intermolecular N–H...Ointeractions form chains of molecules in the crystal structure.

thiophene-3-carboxamide

The two title compounds, 2-([(1Z)-[4-(dimethylamino)phenyl]methylene]amino)-4,5-dimethyl-N-(2-methylphenyl)thiophene-3-carboxamide, C(23)H(25)N(3)OS, (I), and 2-([(1E)-[4-(dimethylamino)phenyl]methylene]amino)-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide,C(25)H(27)N(3)OS, (II), show antibacterial and antifungal activities. The asymmetric unit of (II) contains two crystallographically independent molecules. The o-toluidine ring in (I) lies gauche with respect to the thiophene ring. In (II), the p-toluidine ring is coplanar with the thiophene ring in one molecule, but is tilted from it in the other molecule. Neither structure exhibits any significant intermolecular interactions, but in both, an intramolecular N-H.N hydrogen bond forms a pseudo-six-membered ring, thus locking the molecular conformation and removing conformational flexibility.

Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate

The title compound, C24H24N2O3S, exhibits antifungal and antibacterial properties. The compound crystallizes with two molecules in the asymmetric unit, with one molecule exhibiting orientational disorder in the crystal structure with respect to the cyclohexene ring. The o-toluidine groups in both molecules are noncoplanar with the respective cyclohexene-fused thiophene ring. In both molecules, there is an intramolecular N-H...N hydrogen bond forming a pseudo-six-membered ring which locks the molecular conformation and eliminates conformational flexibility. The crystal structure is stabilized by O-H...O hydrogen bonds; both molecules in the asymmetric unit form independent chains, each such chain consisting of alternating ordered and disordered molecules in the crystal lattice.

2-[(E)-Benzyl­ideneamino]-N-(2-fluoro­phenyl)-4,5,6,7-tetrahydro-1-benzothio­phene-3-carboxamide

The conformation of the title molecule,

2-(Acetamido)-4,5-dimethyl-N-(2-methyl-phenyl)thiophene-3-carboxamide

C_{24}H_{26}N_2O_4S