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Featured researches published by K. J. MacKelvie.


Journal of Bone and Mineral Research | 2002

A Randomized School-Based Jumping Intervention Confers Site and Maturity-Specific Benefits on Bone Structural Properties in Girls: A Hip Structural Analysis Study†

Moira A. Petit; Heather A. McKay; K. J. MacKelvie; Ari Heinonen; Karim M. Khan; Thomas J. Beck

We compared 7‐month changes in bone structural properties in pre‐ and early‐pubertal girls randomized to exercise intervention (10‐minute, 3 times per week, jumping program) or control groups. Girls were classified as prepubertal (PRE; Tanner breast stage 1; n = 43 for intervention [I] and n = 25 for control [C]) or early‐pubertal (EARLY; Tanner stages 2 and 3; n = 43 for I and n = 63 for C). Mean ± SD age was 10.0 ± 0.6 and 10.5 ± 0.6 for the PRE and EARLY groups, respectively. Proximal femur scans were analyzed using a hip structural analysis (HSA) program to assess bone mineral density (BMD), subperiosteal width, and cross‐sectional area and to estimate cortical thickness, endosteal diameter, and section modulus at the femoral neck (FN), intertrochanter (IT), and femoral shaft (FS) regions. There were no differences between intervention and control groups for baseline height, weight, calcium intake, or physical activity or for change over 7 months (p > 0.05). We used analysis of covariance (ANCOVA) to examine group differences in changes of bone structure, adjusting for baseline weight, height change, Tanner breast stage, and physical activity. There were no differences in change for bone structure in the PRE girls. The more mature girls (EARLY) in the intervention group showed significantly greater gains in FN (+2.6%, p = 0.03) and IT (+1.7%, p = 0.02) BMD. Underpinning these changes were increased bone cross‐sectional area and reduced endosteal expansion. Changes in subperiosteal dimensions did not differ. Structural changes improved section modulus (bending strength) at the FN (+4.0%, p = 0.04), but not at the IT region. There were no differences at the primarily cortical FS. These data provide insight into geometric changes that underpin exercise‐associated gain in bone strength in early‐pubertal girls.


British Journal of Sports Medicine | 2002

Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic review

K. J. MacKelvie; Karim M. Khan; Heather A. McKay

This systematic review examines and compares the bone mineral changes in children and adolescents, as measured by dual energy x ray absorptiometry, reported in exercise intervention studies. The effects of hormonal factors and growth on bone mineral change during puberty are examined, and the possibility of a critical period during which bone is especially adaptable to exercise is discussed.


Journal of Bone and Mineral Research | 2002

Bone Mineral Response to a 7-Month Randomized Controlled, School-Based Jumping Intervention in 121 Prepubertal Boys: Associations With Ethnicity and Body Mass Index

K. J. MacKelvie; Heather A. McKay; Moira A. Petit; O. Moran; Karim M. Khan

We examined the effects of a 7‐month jumping intervention (10 minutes, 3 times per week) on bone mineral gain in prepubertal Asian and white boys (10.3 ± 0.6 years, 36.0 ± 9.2 kg) at 14 schools randomized to control (n = 60) and intervention (n = 61) groups. Intervention and control groups had similar mean baseline and change in height, weight, lean mass and fat mass, baseline areal bone mineral density (aBMD; g/cm2), bone mineral content (BMC; g; dual‐energy X‐ray absorptiometry [DXA], QDR 4500W), and similar average physical activity and calcium intakes. Over 7 months, the intervention group gained more total body (TB) BMC (1.6%, p < 0.01) and proximal femur (PF) aBMD (1%, p < 0.05) than the control group after adjusting for age, baseline weight, change in height, and loaded physical activity. We also investigated the 41 Asian and 50 white boys (10.2 ± 0.6 years and 31.9 ± 4.4 kg) who were below the 75th percentile (19.4 kg/m2) of the cohort mean for baseline body mass index (BMI). Boys in the intervention group gained significantly more TB and lumbar spine (LS) BMC, PF aBMD, and trochanteric (TR) aBMD (+ ∼2%) than boys in the control group (adjusted for baseline weight, final Tanner stage, change in height, and loaded physical activity). Bone changes were similar between Asians and whites. Finally, we compared the boys in the control group (n = 16) and the boys in the intervention group (n = 14) whose baseline BMI fell in the highest quartile (10.5 ± 0.6 years and 49.1 ± 8.2 kg). Seven‐month bone changes (adjusted as aforementioned) were similar in the control and intervention groups. In summary, jumping exercise augmented bone mineral accrual at several regions equally in prepubertal Asian and white boys of average or low BMI, and intervention effects on bone mineral were undetectable in high BMI prepubertal boys.


British Journal of Sports Medicine | 2005

Ground Reaction Forces Associated with an Effective Elementary School based Jumping Intervention

Heather A. McKay; G. C. Tsang; Ari Heinonen; K. J. MacKelvie; D. Sanderson; Karim M. Khan

Background: Mechanical loading during childhood plays a critical role in normal growth and development of the skeleton. Ground reaction forces (GRFs) may provide a surrogate measure for the strain experienced by bone on landing and at take off. However, there appear to be no paediatric studies that assess GRFs across a variety of loading activities. Objectives: To measure biomechanical variables in commonly performed childhood activities used in an elementary physical education intervention study which augmented bone health in boys and girls. Methods: Maximal GFR, maximal rates of force, and time to maximum force were measured for 12 different jumping activities on a force platform. The jumps measured were drop jumps from 10, 30, and 50 cm, all followed by a plyometric jump, submaximal and maximal jumping jacks, alternating feet jump, counter movement jumps, and side to side jumps over 10 and 20 cm foam barriers. The subjects were 70 children (36 boys and 34 girls), 8.3–11.7 years old. Results: Subjects ranged in height from 128.4 to 172.6 cm and had a mass of 25.0–57.0 kg. Mean (SD) for vertical jump was 24.2 (5.5) cm and 135.2 (16.6) cm for standing long jump. The children engaged in loaded physical activity 5.7 (5.3) hours a week, on average. The highest mean maximal GRFs, normalised for body weight (BW), were generated from the plyometric portion of the drop jumps and the counter movement jump (about 5 times BW) compared with 3.5 times BW for jumping jacks. Similarly, the highest rates of change in force were 514 times BW/s for the drop jump from 10 cm and 493 times BW/s for the counter movement jump. Conclusions: Simple jumps requiring minimal equipment produce GRFs of 3.5–5 times BW and rates of force of around 500 times BW/s. As children appear to attenuate higher impact forces when jumping from increased heights, it cannot be assumed that merely increasing the height of the jump will necessarily “progress” the exercise intervention.


Medicine and Science in Sports and Exercise | 2001

Lifestyle risk factors for osteoporosis in Asian and Caucasian girls.

K. J. MacKelvie; Heather A. McKay; Karim M. Khan; Peter R.E. Crocker

PURPOSE We investigated ethnic differences in areal bone mineral density (aBMD; g x cm(-2)) and its determinants at two levels of maturity in Asian- and Caucasian-Canadian girls. METHODS Participants were 131 Asian (26 Tanner breast stage I (aTI) and 30 Tanner II (aTII)), and Caucasian (30 Tanner I (cTI) and 45 Tanner II (cTII)) girls. We measured calcium intake by a food frequency questionnaire, general physical activity, and extracurricular sports with a modified Physical Activity Questionnaire for Children and loaded physical activity by 7-d recall. Fat mass, lean mass, and aBMD for the total body (TB), and aBMD at the lumbar spine (LS), proximal femur (PF), femoral neck (FN), and trochanter (TR) were measured by DXA (Hologic QDR 4500). We used ANCOVA (controlling for size and lean and fat mass) to compare bone mineral content (BMC) and aBMD between ethnicities within Tanner stages. RESULTS Calcium intake was significantly lower for Asian girls in both TI and TII (P < 0.001) as compared with Caucasians. For physical activity measures, only the general score was greater in cTI than aTI (P < 0.05). Participation in loaded physical activities and extracurricular sports was significantly less for aTII than cTII (both, P < 0.01), whereas general physical activity did not differ. aBMD measures were similar between aTI and cTI. However, TB, PF, FN, and aBMD were significantly lower (approximately 9-14%) in aTII as compared with cTII. CONCLUSION Thus, there was greater ethnic disparity in lifestyle factors related to bone health and absolute measures of bone mineral with advanced maturity.


Obesity | 2008

GLP-1 and Appetite Responses to a Meal in Lean and Overweight Adolescents Following Exercise

Jean-Pierre Chanoine; K. J. MacKelvie; Susan I. Barr; Alfred C. K. Wong; Graydon S. Meneilly; Dariush Elahi

Objective: Increased physical activity is an integral part of weight loss programs in adolescents. We prospectively investigated the effects of exercise on glucagon‐like peptide‐1 (GLP‐1) concentrations and on appetite markers.


Journal of Clinical Densitometry | 2004

Application of magnetic resonance imaging to evaluation of femoral neck structure in growing girls

Heather A. McKay; Harri Sievänen; Moira A. Petit; K. J. MacKelvie; Ken M. Forkheim; Ken P. Whittall; Bruce B. Forster; Heather M. Macdonald

Conventional density measures by dual-energy X-ray absorptiometry (DXA) are confounded by increases in bone size and do not assess bone geometry. We assessed precision of magnetic resonance imaging (MRI) and used MRI, DXA, and hip structure analysis (HSA) to assess 7-mo changes in bone structure at the femoral neck in 18 prepubertal girls. At baseline, girls were 10.4 (0.5) yr, 144.0 (8.2) cm, and 35.2 (7.0) kg, on average. Total bone and cortical cross-sectional area (ToA and CoA) were calculated from high-resolution T1-weighted MRI oblique axial images of the femoral neck. We used proximal femur DXA scans (Hologic QDR-4500) and the HSA program to estimate bone cross-sectional area (CSA), and calculate section modulus. MRI precision was determined by scanning 10 volunteers (13-46 yr old) three times with and without repositioning. Precision (CVrms) was 2% for ToA and 7% for CoA. Significant correlations were observed between FN area and MRI-derived ToA (r = 0.57, p = 0.013) and CoA (r = 0.47, p = 0.050). There were significant positive changes over 7 mo by both methods. In conclusion, MRI provides useful information on femoral neck bone area in children. The reproducibility of cortical dimensions at the femoral neck needs improvement through technical modifications and appropriate analysis software.


Pediatrics | 2003

A School-Based Exercise Intervention Elicits Substantial Bone Health Benefits: A 2-Year Randomized Controlled Trial in Girls

K. J. MacKelvie; Karim M. Khan; Moira A. Petit; Patricia A. Janssen; Heather A. McKay


The Journal of Pediatrics | 2001

A school-based exercise intervention augments bone mineral accrual in early pubertal girls☆☆☆

K. J. MacKelvie; Heather A. McKay; Karim M. Khan; Peter R.E. Crocker


Bone | 2004

Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys

K. J. MacKelvie; Moira A. Petit; Karim M. Khan; Thomas J. Beck; Heather A. McKay

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Heather A. McKay

University of British Columbia

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Karim M. Khan

University of British Columbia

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Ari Heinonen

University of Jyväskylä

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Heather M. Macdonald

University of British Columbia

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Peter R.E. Crocker

University of British Columbia

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Bruce B. Forster

University of British Columbia

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Thomas J. Beck

Johns Hopkins University

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Alfred C. K. Wong

University of British Columbia

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Graydon S. Meneilly

University of British Columbia

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