K. L. Yang

High-resolution human leukocyte antigen (HLA) haplotypes and linkage disequilibrium of HLA-B and -C and HLA-DRB1 and -DQB1 alleles in a Taiwanese population

Using the maximum-likelihood method with the expectation-maximization (EM) algorithm of PYPOP, high-resolution human leukocyte antigen (HLA) three-locus haplotypes (HLA-A, -B, and -C; HLA-A, -B, and -DRB1) and four-locus haplotypes (HLA-A, -B, -C, and -DRB1) were determined. Linkage disequilibrium of high-resolution HLA-B and -C alleles and HLA-DRB1 and -DQB1 alleles was also calculated. Comparison of the Taiwanese haplotypes and haplotypes from donors in the Chinese Han population, the Asia Pacific Islander ethnic category of the NMDP (National Marrow Donor Program), and the Taiwanese cord blood units demonstrated similarities and dissimilarities among the four populations. HLA allele frequencies of our study suggested that the Taiwanese have a relative population relationship with the southern Han Chinese with regard to HLA. Our results also indicated that the Taiwanese population exhibits genetic proximity with Asian Americans with regard to HLA-A and -DRB1 but not HLA-B.

HLA-A*02:541, a novel variant of HLA-A*02, discovered in a Taiwanese unrelated hematopoietic stem cell donor.

Two nucleotide changes at residue 524 and residue 527 of HLA-A*02:07:01 results in a novel allele, HLA-A*02:541.

Detection of HLA-DRB1*04:207, a novel HLA-DRB1*04 variant, in a Taiwanese hematopoietic stem cell donor

Recombination may result in the formation of HLA‐DRB1*04:207.

HLA-A*11:235Q, a novel HLA-A*11 variant, detected in a Taiwanese individual

Nucleotide deletions from residue 120 to 125 of HLA‐A*11:01:01:01 result in a novel allele, HLA‐A*11:235Q.

HLA-A*02:466, a variant of HLA-A*02, discovered in a Taiwanese unrelated hematopoietic stem cell donor

One nucleotide replacement at residue 228 of the human leukocyte antigen HLA-A*02:03:01 results in a novel allele, HLA-A*02:466.

HLA-B*40:306, a novel variant of HLA-B*40, discovered in a Taiwanese bone marrow hematopoietic stem cell donor.

One nucleotide substitution at residue 308 of the HLA‐B*40:06:01:01 results in a new allele, HLA‐B*40:306.

Identification of a novel HLA-A*02 variant, HLA-A*02:586, in a Taiwanese bone marrow hematopoietic stem cell donor.

One nucleotide substitution at residue 179 of the HLA‐A*02:07:01 results in a new allele, HLA‐A*02:586.

HLA-B*15:327, a novel variant ofHLA-B*15, discovered in a Taiwanese unrelated hematopoietic stem cell donor: NEW ALLELE Alerts

One nucleotide substitution at residue 86 of HLA-B*15:27:01 results in a new allele, HLA-B*15:327.

Detection of a novel HLA‐B*15 variant, HLA‐B*15:01:37, in a Taiwanese unrelated hematopoietic stem cell donor

One nucleotide substitution at residue 531 of HLA-B*15:01:01:01 results in a new allele, HLA-B*15:01:37.

HLA-A*02:06:21, a novel variant of HLA-A*02:06, discovered in a Taiwanese bone marrow hematopoietic stem cell donor.

One nucleotide substitution at residue 318 of the HLA‐A*02:06:01:01 results in a new allele, HLA‐A*02:06:21.One nucleotide substitution at residue 318 of the HLA-A*02:06:01:01 results in a new allele, HLA-A*02:06:21.