K. P. Sharma

Antioxidant rich diet supplements (Spirulina and tamarind fruit pulp) mitigate hematological disorders in fluoride exposed mice

The effect of antioxidant rich diet supplements of Spirulina and tamarind fruit pulp at 230 mg kg−1 body weight, separately as well as in combination, on various hematological parameters of Swiss albino mice exposed to fluoride for seven days at daily doses of 190 mg kg−1 body weight and for 90 days at daily doses of 94 mg kg−1 body weight is reported. Compared with controls, fluoride exposure decreased erythrocyte (12%–18%), leukocyte (16%) and platelet counts (7%, only for short-term exposure), hemoglobin (2%–17%) and packed cell volume (2%–14%) in Swiss albino mice reared on standard feed but these were altered little in the diet supplement groups. Fluoride exposure decreased lymphocytes in both standard feed (16%–21%) and diet supplement groups (5%–19%, but only after long-term exposure). Fluoride withdrawal led to recovery of the post-treated mice from long-term exposure. Spirulina alone and also in combination with tamarind fruit pulp was found more effective than tamarind alone in reducing hematological disorders in fluoride treated mice.

Dietary Spirulina platensis alleviates aluminum and aluminum fluoride induced histopathological and biochemical alterations in mice kidney

Aluminum and its salts widely used in our daily life have been reported nephrotoxic to humans and animals following prolonged exposure. Therefore, the present study was made to examine the renoprotective role of Spirulina platensis against Al3+ and AlF3 in male Swiss albino mice. Exposure to these chemicals decreased feed and water intake, and body and kidney weights. Histology of kidney and their biochemistry were also markedly altered along with that of serum biochemistry. Spirulina not only minimize toxic effects of test chemicals but also favored faster recovery of treated mice after their withdrawal.

Risk Assessment of Groundwater of Sanganer Industrial Area (Jaipur) on Hematology of Swiss Albino Mice

Blood is primary target to environmental toxicants. Hematological study is an important diagnostic tool and has proved that they may be used as valuable sensitive indicators of toxicity due to different pollutant. Hematological values are widely used to determine systematic relationship and physiological adaptations including the assessment of general health conditions. In the present study, long term exposure (180 days) of groundwater of Sanganer Industrial Area on various Hematological parameters (RBC count, WBC count, Hb%, PCV, MCV, MCH, MCHC, poikilocytosis and anisocytosis of RBC) in Mus musculus.