K.P. Volcho

New possibilities of isoprenoids chemistry when using a heterogeneous catalyst: Askanite—bentonite clay

Abstract We showed that new heterocyclization reactions resulting in the compounds of a unique structure and a potential biological activity proceed when hydroxyolefins of menthane and carane seriies are allowed to react with salicylaldehyde 1 on askanite—bentonite clay at room temperature. Slight changes in isoprenoid structure yield significantly different reaction products.

Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins

The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.