K. Shanker

AMOEBICIDAL AND FUNGICIDAL ACTIVITIES OF NEW QUINAZOLONES

Eleven quinazolones were synthesized by condensing 2-phenylanthranil with a suitable peptide in pyridine. The compounds synthesized were characterised by their sharp melting points, elemental analysis and IR spectra. The newly synthesized compounds were tested for their amoebicidal and fungicidal activities. Some of the compounds showed promising results.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF QUINOLINE HYDROCHLORIDES AS ANTHELMINTICS

In the present paper twenty five benzene substituted-4-amino quinoline derivatives were synthesized by condensation of 4-chloroquinolines with alkyl p-aminobenzoate or salicylate. The compounds were screened for antiacetylcholinesterase activity and also anthelmintic activity against Hymenolepis nana. Some of these compounds have shown interesting results.

NEW IMIDAZOLYLTHIOCARBAMIDES AS GUANINE DEAMINASE INHIBITORS

Guanine deaminase is an important enzyme of purine catabolism which irreversibly deaminates guanine (1) to xanthine (2) and also 8-azaguanine to 8-azaxanthine. 8-Azaguanine is a carcinostatic agent whereas 8-azaxanthine is non-carcinostatic. It has been proposed that the selective action of thioguanine and 8-azaguinine on certain tissue is due to lack of guanine deaminase in these susceptible cell lines. Inhibitors of guanine deaminase are important because it is reasonable to postulate that it will inhibit the conversion of 8-azaguanine to 8-azaxanthine and these could be used with advantage along with thioguanine and 8-azaguanine. This paper reports synthesis of new imidazolylthiocarbamides as guanine deaminase inhibitors.