K. Yu. Suponitskii
Russian Academy of Sciences
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Featured researches published by K. Yu. Suponitskii.
Chemistry of Natural Compounds | 2013
I. P. Tsypysheva; A. V. Koval’skaya; A. N. Lobov; M. Kh. Salimgareeva; U. Sh. Fatkullina; P. R. Petrova; S. F. Gabdrakhmanova; N. S. Makara; K. Yu. Suponitskii; Yu. V. Vakhitova; F. S. Zarudii; M. S. Yunusov
The neuropharmacological activity of two (–)-cytisine derivatives with adamantyl fragments was studied. It was shown that N-1-adamantylcytisine-12-thiocarbamide exhibited in tests in vivo a pronounced mnestic effect, increased the lifespan of laboratory animals under hypoxic conditions, and also enhanced in vitro binding of transcription factors NFAT and NF-κB to the DNA sequences corresponding to them.
Journal of Structural Chemistry | 2015
S. I. Levchenkov; I. N. Shcherbakov; L. D. Popov; A. I. Uraev; K. Yu. Suponitskii; A. A. Zubenko; A. M. Ionov; V. A. Kogan
Pyrazolate bridging binuclear copper(II) complex with a heterocyclic azomethyne ligand (a condensation product of 1,3-diaminopropanol-2 with 1-phenyl-3-methyl-4-formyl-5-mercaptopyrazole) is synthesized and structurally characterized. The structure of the complex is compared with the structure of its pyrazolone analogue. It is shown that for the 2J calculation the use of the previously optimized geometry rather than the geometry from the XRD data results in better agreement with the magnetochemical experiment.
Russian Journal of Coordination Chemistry | 2014
S. I. Levchenkov; I. N. Shcherbakov; L. D. Popov; V. G. Vlasenko; K. Yu. Suponitskii; A. A. Tsaturyan; V. V. Lukov; V. A. Kogan
The binuclear copper(II) complex [Cu2L(CH3COO)] (I), where L3− is the azomethine trianion based on 3-methyl-4-formyl-1-phenylpyrazol-5-one and 1,3-diaminopropan-2-ol, and its DMSO adduct (II) in which the DMSO molecule acts as an additional bridging ligand are synthesized. The structure of complex II is determined by X-ray diffraction analysis, and the structure parameters of the coordination unit of complex I are determined by EXAFS spectroscopy. The μ2-coordination of the DMSO molecule in compound II results in a change in the sign of the exchange interaction parameter. In complex I, the antiferromagnetic exchange interaction (2J = −169 cm−1) occurs between the copper(II) ions. The exchange interaction of the ferromagnetic type (2J = 174 cm−1) is observed in complex II. The quantum-chemical calculations of the magnetic exchange parameters by the density functional theory method show that the role of the DMSO molecule as a switch of the exchange interaction character is exclusively the stabilization of the “broken” conformation of the metallocycles.
Russian Journal of Coordination Chemistry | 2006
Yu. M. Chumakov; N. M. Samus; Gabriele Bocelli; K. Yu. Suponitskii; V. I. Tsapkov; A. P. Gulya
Abstract3-Phenylpropenal thiosemicarbazone hydrate C6H5-HC=CH-CH=N-NH-C(S)-NH2 · H2O (HL · H2O, I) and two chelates [Ni(L)2] · nCH3OH (II) and [Zn(L)2] (III) are studied by X-ray diffraction. The crystals of I are orthorhombic: a = 6.227(1) Å, b = 7.763(2) Å, c = 25.585(5) Å, β = 90°, space group P212121, Z = 4, R = 0.0426. A nonplanar molecule of I has an E conformation. The crystals of II are triclinic: a = 6.551(2) Å, b = 10.752(3) Å, c = 10.885(3) Å, α = 64.751(5)°, β = 82.753(5)°, γ = 89.857(5)°, space group, Z = 1, R = 0.0661. In a centrosymmetric molecule of II, the central atom coordinates two deprotonated ligands L through the immine nitrogen atom and thioamide sulfur atom at the vertices of a distorted square. The crystals of III are monoclinic: a = 25.342(2) Å, b = 9.150(2) Å, c = 21.340(3) Å, α = 90°, β = 111.84(2)°, γ = 90°, space group C2/c, Z = 8, R = 0.0556. In a molecule of complex III, two deprotonated bidentate ligands L are coordinated by the zinc ion through the immine nitrogen atoms and thioamide sulfur atoms to form a distorted tetrahedron at the central atom. In both II and III, ligand L after coordination by the metal ion changes the E conformation with respect to the N(1)-C(2) bond for the Z conformation. In crystals I-III, molecules are packed to form infinite layers parallel to the planes (001) and (010).
Chemistry of Natural Compounds | 2003
L. Yu. Ukhin; K. Yu. Suponitskii; V. G. Kartsev
Abstract1-Organoacetylene derivatives were prepared by reaction of cotarnine hydrochloride with silver organoacetylenides with brief heating in acetonitrile. The structure of one of these, 1-(3′-hydroxypropyn-1-yl)-2-methyl-6,7-methylenedioxy-8-methoxy-1,2,3,4-tetrahydroisoquinoline, wasproved by an X-ray structure analysis.
Russian Journal of Coordination Chemistry | 2011
Yu. P. Tupolova; L. D. Popov; S. I. Levchenkov; I. N. Shcherbakov; K. Yu. Suponitskii; A. M. Ionov; V. A. Kogan
Abstract1,3-Diaminopropan-2-ol N,N′-bis(3-formyl-5-tert-butylsalicylidene) (H3L) and the binuclear copper(II) complex based on H3L, [Cu2L(CH3COO)] (I), are synthesized. The compounds are studied by IR and 1H NMR spectroscopies, magnetochemistry, and X-ray diffraction analysis. Compared to the copper(II) complexes with 1,3-diaminopropan-2-ol N,N′-bis(salicylidene), complex I is characterized by a substantial change in the structure resulting in weakening of the antiferromagnetic exchange interaction.
Russian Journal of General Chemistry | 2008
E. V. Buravlev; I. Yu. Chukicheva; K. Yu. Suponitskii; A. V. Kuchin
New tertiary aminomethylphenols having an isobornyl fragment in the ortho position with respect to the phenolic hydroxy group were synthesized by the Mannich reaction.
Russian Journal of Organic Chemistry | 2007
R. R. Gataullin; N. A. Likhacheva; K. Yu. Suponitskii; I. B. Abdrakhmanov
N-Acyl-2-(cyclohex-2-en-1-yl)anilines react with molecular iodine to give the corresponding N-acyl-1-iodo-1,2,3,4,4a,9a-hexahydrocarbazoles which undergo isomerization into 1-R-2a,3,4,5,5a,10a-hexahydro[1,3]oxazolo[5,4,3-j,k]carbazol-10-ium iodides; no isomerization occurs with N-acetyl-3-iodo1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole. The reaction of N-p-tolylsulfonyl-3,4,4a,9a-tetrahydrocarbazoles with hydrogen peroxide leads to the formation of a single 1,2-epoxy derivative with trans orientation of the nitrogen-and oxygen-containing rings. N-p-Tolylsulfonyl-1,3a,4,8b-tetrahydrocyclopenta[b]indoles give rise to the corresponding 2,3-epoxy derivatives with both trans and cis orientation of the dihydropyrrole and oxirane fragments. The resulting epoxides undergo trans-opening with formation of N-p-tolylsulfonyl-1-hydroxy-2-methoxy-1,2,3,4,4a,9a-hexahydrocarbazoles and N-p-tolylsulfonyl-3-hydroxy-2-methoxy-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indoles on heating in methanol in the presence of KU-2 cation exchanger. Mutual orientation of the oxirane and nitrogen-containing rings in the epoxides derived from cyclopenta[b]-indoles was proved by X-ray analysis.
Chemistry of Natural Compounds | 2011
O. B. Kazakova; E. Yu. Yamansarov; O. S. Kukovinets; N. I. Medvedeva; Dmitri V. Kazakov; O. K. Kornilov; K. Yu. Suponitskii
Ozonolysis of 3β,28-di-O-acetyl-29-norlupan-20-one-O-methylketoxime in the presence of ketones was used as an example to show that secondary ozonides at the C20 position of betulin are unstable and decompose to form the “anomalous product” methyl-3β,28-di-O-acetyl-29,30-bisnorlupan-20-oate, the structure of which was proved by an x-ray crystal structure analysis.
Russian Journal of Coordination Chemistry | 2014
A. I. Uraev; L. D. Popov; S. I. Levchenkov; I. N. Shcherbakov; V. G. Vlasenko; K. Yu. Suponitskii; S. S. Beloborodov; D. A. Garnovskii; V. A. Kogan
The copper(II) and nickel(II) complexes based on bis(azomethine), which is the condensation product of 1-phenyl-3-methyl-4-formyl-5-mercaptopyrazole with 1,3-diaminopropan-2-ol, are synthesized. Bis-azomethines can form both binuclear and mononuclear complexes in which the hydroxy group is not involved in coordination. The binuclear copper(II) complexes with the acetate and pyrazolate bridges exhibit an antiferromagnetic exchange, which strength is determined by the nature of the bridge (2J = −154 and −424 cm−1, respectively). The structure parameters of the coordination spheres of the complexes are determined by X-ray absorption spectroscopy. The structure of the CHCl3 solvate of the binuclear copper(II) complex with the pyrazolate bridge is solved by X-ray diffraction analysis (CIF file CCDC 964655).