Kai H. Liao
Colorado State University
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Publication
Featured researches published by Kai H. Liao.
Journal of Exposure Science and Environmental Epidemiology | 2007
Yu-Mei Tan; Kai H. Liao; Harvey J. Clewell
Biomonitoring data provide evidence of exposure of environmental chemicals but are not, by themselves, direct measures of exposure. To use biomonitoring data in understanding exposure, physiologically based pharmacokinetic (PBPK) modeling can be used in a reverse dosimetry approach to assess a distribution of exposures possibly associated with specific blood or urine levels of compounds. Reverse dosimetry integrates PBPK modeling with exposure pattern characterization, Monte Carlo analysis, and statistical tools to estimate a distribution of exposures that are consistent with biomonitoring data in a population. The present study used an existing PBPK model for chloroform as a generic framework to develop PBPK models for other trihalomethanes (THMs). Using Monte Carlo sampling techniques, probabilistic information about pharmacokinetics and exposure patterns was included to estimate distributions of THMs concentrations in blood in relation to various exposure patterns in a diverse population. In addition, the possibility of inhibition of hepatic metabolism among THMs was evaluated under the scenarios of household exposure. These studies demonstrated how PBPK modeling can be used as a tool to estimate a population distribution of exposures that could have resulted in particular biomonitoring results. When toxicity level is known, this tool can also be used to estimate proportion of population above levels associated with health risk.
Environmental Toxicology and Pharmacology | 2004
Raymond S. H. Yang; Hisham A. El-Masri; Russell S. Thomas; Ivan D. Dobrev; James E. Dennison; Dong-Soon Bae; Julie A. Campain; Kai H. Liao; Brad Reisfeld; Melvin E. Andersen; Moiz Mumtaz
Environmental Health Perspectives | 2002
Michael T. Klein; Gang Hou; Richard J. Quann; Wei Wei; Kai H. Liao; Raymond S. H. Yang; Julie A. Campain; Monica A. Mazurek; Linda J. Broadbelt
Environmental Health Perspectives | 2002
Kai H. Liao; Ivan D. Dobrev; James E. Dennison; Melvin E. Andersen; Brad Reisfeld; Kenneth F. Reardon; Julie A. Campain; Wei Wei; Michael T. Klein; Richard J. Quann; Raymond S. H. Yang
Risk Analysis | 2007
Kai H. Liao; Yu-Mei Tan; Rory B. Conolly; Susan J. Borghoff; Michael L. Gargas; Melvin E. Andersen; Harvey J. Clewell
Mouse Models of Human Cancer | 2004
Raymond S. H. Yang; James E. Dennison; Melvin E. Andersen; Ying C. Ou; Kai H. Liao; Brad Reisfeld
Toxicological Sciences | 2006
Melvin E. Andersen; Roman W. Lutz; Kai H. Liao; Werner Lutz
Environmental Health Perspectives | 2001
Kai H. Liao; Daniel L. Gustafson; Michael H. Fox; Laura S. Chubb; Kenneth F. Reardon; Raymond S. H. Yang
Archive | 2005
Raymond S. H. Yang; Arthur N. Mayeno; Kai H. Liao; Kenneth F. Reardon; Brad Reisfeld
Journal of Chromatography B | 2005
Kai H. Liao; Arthur N. Mayeno; Kenneth F. Reardon; Raymond S. H. Yang