Kai-Ju Wei

Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein

A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be largely influenced by small molecules with a strong trans effect.

Anion effect on construction of two Cd(II) coordination polymers with phenylformic acid-imidazole ditopic ligand: Hydrothermal synthesis, crystal structure and antimicrobial activity

Two new coordination polymers, [Cd(L−H)2] ∞ (1) and [Cd(L−H)(NO3)] ∞ (2) (L = C10H8N2O2), have been synthesized by hydrothermal reactions of 4-(imidazole-1-yl)-benzoic acid and CdX2 (X = and ). X-ray single crystal diffraction demonstrates that the counterion has an important effect on the assembly process. Crystals of 1 were orthorhombic, space group Pnna, with a = 13.8052(6), b = 16.5126(10) and c = 8.2158(12). Complex 2 crystals were isolated as orthorhombic, space group Pbca, with a = 7.9988(6), b = 15.8290(11) and c = 17.9580(13). Cd2+ is six-coordinate in a distorted octahedral geometry in both complexes. In 1, L bridges the metal centers with the intramolecular Cd ··· Cd separation of 11.651 Å, resulting in an infinite rhombic grid; is not in the grid. In 2, adjacent Cd(II)s were linked by L, and further by nitrate and carboxylate, producing an infinite zigzag chain. The toxicity of the two complexes is evaluated by testing antimicrobial activity against bacterial strands using the agar diffusion method.

Unexpected helicity control and helix inversion: homochiral helical nanotubes consisting of an achiral ligand

The ligand tppda has been designed and synthesized as molecular leverage for helicity control when reacted with Cd(2+) ions. The guests MeOH or DMF preferentially stabilize the P-helical isomer, while the guest H2O causes a helix inversion to give the M-helical isomer as the major isomer without any chiral auxiliary.

Chemical and cellular investigations of trans-ammine-pyridine-dichlorido-platinum(II), the likely metabolite of the antitumor active cis-diammine-pyridine-chorido-platinum(II)

It has been proposed that the well-studied monofunctional platinum complex cis-[PtCl(NH3)2(py)](+) (cDPCP) forms DNA adducts similar to those of the trans platinum complex trans-[PtCl2(NH3)(py)] (ampyplatin, py=pyridine). Thus this latter could be the active form of cDPCP. Detailed studies on the mechanism of ampyplatin action were performed in this work. Results indicate that ampyplatin has significantly higher antiproliferative activity than cDPCP and is comparable to cisplatin. Cellular uptake experiments indicate that ampyplatin can be efficiently accumulated in A549 cancer cells. Binding of ampyplatin to DNA mainly produces monofunctional adducts; remarkably, these adducts can be recognized by the HMGB1 protein. Kinetic studies on the reaction with GMP indicate that the reactivity of ampyplatin is much lower than that of transplatin and is more similar to that of trans-[PtCl2{E-HN=C(Me)OMe}2] (trans-EE), a widely investigated antitumor active trans-oriented platinum complex. In addition, the hydrolysis of ampyplatin is significantly suppressed, whereas the hydrolysis of the mono-GMP adduct is highly enhanced. These results indicate that the mechanism of ampyplatin differs not only from that of antitumor inactive transplatin but also from that of antitumor active trans-EE and this could account for the remarkable activity of parent cDPCP.

Hydrothermal Synthesis, Crystal Structure, and Biological Properties of a Mn(II) Complex with Phenylformic Acid-Imidazole Ditopic Ligand

A new Mn(II) coordination complex derived from 4-(imidazole-1-yl)-benzoic acid was synthesized by hydrothermal method and characterized by X-ray single crystal diffraction. Antimicrobial activity and DPPH free radical scavenging activity of the free ligand and its Mn(II) complex have been tested. The result indicated that the title complex shows stronger activity than the free ligand. The catalytic activity of the title complex [(L − H )2Mn(4H2O)] and the effect of added imidazole were also investigated for the disproportionation of hydrogen peroxide.

Self-assembled hetero-bimetallic coordination cage and cation-clusters with µ2-Cl bridging using a flexible two-arm ferrocene amide linker

One flexible, discrete coordination cage [Cu(2)(3-BPFA)(4)(H(2)O)(2)](ClO(4))(4).4CH(3)OH (), and two cation-clusters with micro(2)-Cl bridging [Ni(2)(micro-Cl)(3-BPFA)(4)(H(2)O)(2)](ClO(4))(3) () and [Co(2)(micro-Cl)(3-BPFA)(4)(H(2)O)(2)](ClO(4))(4).4CH(3)OH (), containing the ferrocenyl functionality were prepared via coordination-driven self-assembly and Cl-anion template from Cu(II), Ni(II) and Co(II) salts and a flexible two-arm molecule 1,1-bis[(3-pyridylamino)carbonyl]ferrocene (3-BPFA).

A Turn-Off Fluorescent Nanosensor for Iron in Aqueous Solution Based on Fluorescent Carbon Nanoparticles

The water-soluble fluorescent carbon nanomaterials with low toxicity and high biocompatibility are considered as promising materials for biomedical and sensor applications. Here, we report that a nanosensor system has been developed to simultaneously detect two valence states of iron (Fe2+ and/or Fe3+) in aqueous solution based on fluorescent carbon nanoparticles (FCNs). The nanosensor has high selectivity and sensitivity with a limit of detection (LOD) of 5 μM, which is equivalent to 0.3 mg/L (5.36 μM) of iron in drinking water by United States Environment Protection Agency (US-EPA). Furthermore, a distinguishable color change of solution, from pale yellow to red-brown, can be observed as iron concentration reaching 40 μM, which provides way for fast, visible detection of irons.

CCDC 773760: Experimental Crystal Structure Determination

Related Article: Jia Ni, Kai-Ju Wei, Yuanzeng Min, Yaowen Chen, Shunze Zhan, Dan Li, Yangzhong Liu|2012|Dalton Trans.|41|5280|doi:10.1039/c2dt12032a