Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Kai-Min Chu is active.

Publication


Featured researches published by Kai-Min Chu.


International Journal of Cardiology | 2011

The influence of inflammation outweighing the metabolic syndrome on cardiovascular risk and mortality

Gen-Min Lin; Kai-Min Chu; Chih-Lu Han

☆ The authors declare no conflict of interests and no financial support from any institute. ⁎ Corresponding author. Department of Internal Medicine, Hualien Armed Forces General Hospital. No.163, Jiali Rd., Xincheng Township, Hualien County 97144, Hualien, Taiwan. Tel.: +886 3 826 0601. E-mail address: [email protected] (G.-M. Lin). In a systemic review andmeta-analysis, the metabolic syndrome is associated with a 2-fold increase in cardiovascular outcomes and a 1.5-fold increase in all-cause mortality [1]. Most participants came from general populations and were free of cardiovascular disease. However, we have observed that the influence of metabolic syndrome on cardiovascular risk was blunted in the cohorts of the placebo arm in the JUPITER trial [2]. In the subgroup analysis, the cardiovascular hazard ratio for menwithmetabolic syndrome to thosewithout it was estimated at 0.92, for women: 1.02, for the elderlyN70 years old: 0.80 and for the total placebo cohorts: 0.92 [3,4]. Since the populations enrolled in JUPITER are unique for their baseline characteristics without diabetes, with normal lipid profiles and high C-reactive protein levels (N2 mg/L), those with metabolic syndrome should mainly include central obesity and systemic hypertension in addition to one or more of the other metabolic abnormalities such as an increase of triglyceride, reduction of the HDL-cholesterol and impaired fasting glucose. Obviously obesity, which demonstrates the phenomenon of reverse epidemiology regardless of age and gender, is the only variable in the components of metabolic syndrome (except the cardiovascular incidence rate of fasting glucose was not shown in JUPITER) that could reduce the cardiovascular risk [3,4]. Previously, Aizawa et al. suggested that the five metabolic components do cluster and obesity and insulin resistance were likely to be linked with metabolic syndrome more than hypertension or high triglyceride [5]. As we know, those with obesity and insulin resistance have an increase of inflammatory status and cardiovascular risk compared to general populations. It is surprising that to replace the risk factor of obesity or insulin resistance by inflammation would not alter the cardiovascular incidence for those who have not fulfilled the criteria of themetabolic syndrome. This reflects that inflammation may play a central role in the genesis of metabolic syndrome related cardiovascular risk [6]. Accordingly, the influence of inflammation outweighing metabolic syndrome on cardiovascular risk and mortality is clinically proven. Further, we reason that the finding of Aizawa et al. why obesity and insulin resistance prefer to be clustered in the metabolic syndrome than in other components, is possibly due to these two factors just representing a status of inflammation. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [7].


International Journal of Cardiology | 2011

Pexelizumab may be hazardous to those with ST-segment elevation myocardial infarction undergoing primary percutaneous interventions without using glycoprotein IIb–IIIa inhibitors

Gen-Min Lin; Kai-Min Chu; Chih-Lu Han

Angioplasty Complications (CADILLAC) trial. J Am Coll Cardiol 2004;44:547–53. [16] Aronson D, Suleiman M, Agmon Y, et al. Changes in haemoglobin levels during hospital course and long-term outcome after acute myocardial infarction. Eur Heart J 2007;28:1289–96. [17] Most AS, Ruocco Jr NA, Gewirtz H. Effect of a reduction in blood viscosity on maximal myocardial oxygen delivery distal to a moderate coronary stenosis. Circulation 1986;74:1085–92. [18] Levy PS, Quigley RL, Gould SA. Acute dilutional anemia and critical left anterior descending coronary artery stenosis impairs end organ oxygen delivery. J Trauma 1996;41:416–23. [19] Coats AJ. Ethical authorship and publishing. Int J Cardiol 2009;131:149–50.


Stroke | 2011

Letter by Lin et al Regarding Article, “Hepatitis C Virus Infection and Increased Risk of Cerebrovascular Disease”

Gen-Min Lin; Kai-Min Chu; Chih-Lu Han

To the Editor: We read with interest the work by Lee et al, which reported that chronic hepatitis C virus (HCV) infection is an independent risk predictor of cerebrovascular deaths showing a biological gradient of cerebrovascular mortality with increasing serum HCV RNA level.1 However, their headline and discussions may mislead the readers that HCV infection is associated with not only the increase in mortality rate, but also the incidence rate of stroke. As we know, recent data suggest that approximately one third of HCV-infected patients may progress to liver cirrhosis without antiviral treatment in <20 years.2 Accordingly, a substantial proportion of patients …


International Journal of Cardiology | 2011

What else does the JUPITER trial add regarding C-reactive protein and cardiovascular disease?

Gen-Min Lin; Yi-Hwei Li; Kai-Min Chu; Chih-Lu Han

cardiovascular disease? Gen-Min Lin ⁎, Yi-Hwei Li , Kai-Min Chu , Chih-Lu Han d a Department of Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan b Department of Public Health, Tzu-Chi University, Hualien, Taiwan c Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan d Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan


International Journal of Cardiology | 2011

Reverse epidemiology reflects C-reactive protein as a bystander of atherosclerosis in established systemic inflammation models

Gen-Min Lin; Kai-Min Chu; Chih-Lu Han


Acta Cardiologica Sinica | 2006

Transcatheter Retrieval of Dislodged Port-A Catheter Fragments: Experience with 47 Cases

Tsung-Neng Tsai; Chih-L Han; Wei-Shiang Lin; Shih-Ping Yang; Tien-Pieng Tsao; Kai-Min Chu; Bieng-Hsian Tzeng; Shu-Meng Cheng


Journal of The American Society of Echocardiography | 2006

Perforated Periaortic Valve Abscess Presents as Acute Pericarditis and Patient Died in Transesophageal Echocardiographic Study

Tsung-Neng Tsai; Bing-Hsiean Tzeng; Gou-Jieng Hong; Kai-Min Chu; Shu-Meng Cheng; Shih-Ping Yang


International Journal of Cardiology | 2007

Flailed tricuspid valve as a complication of retrieving fractured catheter

Tsung-Neng Tsai; Kai-Min Chu; Bing-Hsiean Tzeng; Shih-Ping Yang; Wei-Shiang Lin


Acta Cardiologica Sinica | 2014

Activation of Krüppel-Like Factor 2 with Ginkgo Biloba Extract Induces eNOS Expression and Increases NO Production in Cultured Human Umbilical Endothelial Cells

Tsung-Neng Tsai; Wei-Shing Lin; Chun-Hsien Wu; Wen-Yu Lin; Kai-Min Chu; Cheng-Chung Cheng; Chih-Hsueng Hsu; Wei-Che Tsai; Shu-Meng Cheng; Shih-Ping Yang


Archive | 2010

Dobutamine Facilitates Reversion of Atrial and Ventricular Stunning in a Patient after Catheter Ablation of Persistent Atrial Flutter

Shih-Chung Huang; Tsung-Neng Tsai; Shih-Ping Yang; Kai-Min Chu; Wei-Shiang Lin

Collaboration


Dive into the Kai-Min Chu's collaboration.

Top Co-Authors

Avatar

Chih-Lu Han

Taipei Veterans General Hospital

View shared research outputs
Top Co-Authors

Avatar

Tsung-Neng Tsai

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Gen-Min Lin

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Shih-Ping Yang

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Shu-Meng Cheng

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Wei-Shiang Lin

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Bing-Hsiean Tzeng

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Cheng-Chung Cheng

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Chih-Hsueng Hsu

National Defense Medical Center

View shared research outputs
Top Co-Authors

Avatar

Chun-Hsien Wu

National Defense Medical Center

View shared research outputs
Researchain Logo
Decentralizing Knowledge