Kanti Sharma

Studies in Sprioheterocycles: Part XXVIII: Investigation of the Reaction of 3-Aroylmethyleneindolin-2-ones with Thiosemicarbazide and Synthesis of Spiro[3H-indole-3.4'(3'H)-pyrimidin]-2(1H)-ones

Simple and N-substituted 3-aroylmethyleneindolin-2-ones (I) have been obtained by the reaction of indole-2,3-diones with methyl ketones followed by dehydration. The reaction of I with thiosemicarbazide has been investigated to study the effect of substitution on N atom

Investigation of the reaction of 3-aroylmethylene-indol-2-ones with 2-hydrazinobenzothiazole

AbstractThe reactions of 3-aroylmethylene-indol-2-ones with 2-hydrazinobenzothiazole in different media and solvent were investigated. The impact of substitution on indolyl nitrogen was also studied. The chemical structure of the products was proven on the basis of their spectral (IR, 1H-NMR, 13C-NMR, Mass) and analytical studies. Graphical AbstractThe reactions of 3-aroylmethylene-indol-2-ones with 2-hydrazinobenzothiazole in different media and solvent were investigated. The impact of substitution on indolyl nitrogen was also studied.

One-Pot Green Synthesis of 3'-(2-Aminobenzimidazolyl)-2-Phenyl Spiro[4H-Benzopyran-4,2'-Thiazolidin]-4-Ones and Acylation Using Trifluoroacetic Anhydride

Abstract An expeditious one-pot synthesis of a novel heterocyclic system, 3′-(2-aminobenzimidazolyl)-2-phenyl spiro[4H-benzopyran-4,2′-thiazolidin]-4-ones, has been accomplished by condensing substituted hydrazinobenzimidazole, flavanone, and mercaptoacetic acid by conventional heating in ethanol or toluene, and in an ionic liquid, viz., 1-butyl-3-methyl-imidazolium hexafluorophosphate. Excellent yields (85%–90%) and higher purity are obtained in the ionic-liquid-mediated synthesis as compared with the conventional procedure (55%–60%). Further, these compounds were acylated with trifluoroacetic anhydride. The structures of the compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectral data, and elemental analysis. The compounds, upon evaluation for their antibacterial, antifungal, and insecticidal activities, exhibited excellent results. [Supplemental materials are available for this article. Go to the publishers online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Table S1, S2, and S3] GRAPHICAL ABSTRACT