Kappa P. Meadows

Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx

We describe 5 patients with severe pompholyx who did not respond to conventional therapy or who had debilitating side effects from corticosteroids. Low-dose methotrexate was added to their treatment regimens and led to significant improvement or clearing with a favorable side-effect profile. In all 5 patients the need for oral corticosteroid therapy was substantially decreased or eliminated, thus decreasing potential corticosteroid-induced morbidity. In this uncontrolled series of patients with recalcitrant palmoplantar pompholyx, methotrexate was an effective treatment and acted as a steroid-sparing agent.

Pigmented purpuric eruptions of childhood: a series of cases and review of literature.

Pigmented purpuric eruptions comprise a group of benign dermatoses that are characterized clinically by pinpoint petechiae and purpura on a hyperpigmented base and histologically by capillaritis. The etiology of this group of disorders is unknown, although aberrant cell‐mediated immunity has been proposed. Pigmented purpuric eruptions are well characterized in the pediatric population. In this case series we present three children with these disorders and review the clinical subtypes of pigmented purpuric eruptions that have been described in the literature.

Plasmapheresis as a steroid saving procedure in bullous pemphigoid.

Background Bullous pemphigoid is an immunobullous disease affecting predominantly older patients. In severe cases, high‐dose corticosteroids and/or other immunosuppressants are often needed long term to control the disease. These can be associated with serious side‐effects in this patient population.

Neurologic variant of epidermal nevus syndrome with a facial lipoma

A 1‐year‐old girl presented for evaluation of a linear plaque on her forehead. She was born at 36u2003weeks gestation following an uncomplicated pregnancy and delivery. At birth, she was noted to have an enlarged right cheek. She had no seizure history, but developed grand mal seizures 1u2003year later.